Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"DNA Nanotechnology"”.
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Unlocking precision medicine using DNA nanotechnology
… laboratories, as is currently the case. DNA nanotechnology is a potential solution to improving patient access to reliable and inexpensive biomarker monitoring. The flexibility and utility of DNA-based assays have already been demonstrated with various readouts (including …
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DNA nanotechnology for light-emitting plasmonic applications
DNA nanotechnology for light-emitting plasmonic applications - Sara Rocchetti. The development of plasmonic nanocavities allows for the direct observation of light-matter interactions at the nanoscale. Collective oscillations of electrons (SPPs) at a metal-dielectric interface confine light into …
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Advances in Microfluidics and DNA Nanotechnology for Biomolecular Analysis
… a combination of microfluidic techniques and DNA nanotechnology to facilitate protein detection and characterisation purely in the solution phase. Through these approaches, targets are probed in free solution under conditions closer to the native state than allowed by conventional methods, …
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Dynamic DNA Nanotechnology for Probing Single Nucleotide Variants and DNA Modifications
In the last decades, various DNA hybridization probes have been developed that attempt to conquer the challenge of single-nucleotide-variants (SNVs) detection. Even though a powerful toolbox including the toehold-exchange reaction, the dynamic ‘sink’ design, and the polymerase chain reaction (PCR) …
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Applications of nanopore sensing and DNA nanotechnology for the analysis of nucleic acids
… biosensing molecules such as proteins, RNA, and DNA. While solid-state nanopores hold immense promise for sensing applications beyond sequencing, their lack of inherent specificity poses a major challenge. Combining nanopore sensing with DNA nanotechnology enhances the specificity, enabling the …
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Simulation informed design of stimuli responsive structures and higher-order assemblies in DNA nanotechnology
… thermodynamics rather than instrument precision. DNA nanotechnology is a versatile self-assembly technique. Favourable DNA-DNA interactions are mediated by Watson-Crick base pairs which form only between complementary nucleotides. Mutual affinity and equilibrium structure can be programmed by an …
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A computational study of DNA four-way junctions and their significance to DNA nanotechnology
The field of DNA nanotechnology has rapidly evolved over the past three decades, reaching a point where researchers can conceive of and implement both bioinspired and biomimetic devices using the programmed self-assembly of DNA molecules. The sophisticated natural systems that these devices seek to …
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Programmable biomolecular integration and dynamic behavior of DNA-based systems for development of biomedical nano-devices
… role as a carrier of genetic information, DNA has emerged as an engineering material for construction of nano-devices. The advances in the field of DNA nanotechnology have enabled design and synthesis of DNA nanostructures of arbitrary shapes and manipulation of the nanostructures' …
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Decoding the Fabric of Life: Nanopore Sensing of Nucleic Acid Structure from the Primary to the Quaternary
… occurring ribosomes and artificially induced DNA/RNA nanostructures. The structure of nucleic acids is also intimately linked to their biological function. In this thesis, I leveraged RNA/DNA nanotechnology and solid-state nanopore sensing to detect RNA structural modifications and to …
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DNA Canvas: Towards affordable and scalable enzymatic fabrication of DNA nanoarrays
In biological systems, DNA serves as a carrier of hereditary information, facilitated by predictable and programmable base-pairing rules. The field of DNA nanotechnology takes the DNA molecule out of its original context and using the same set of rules to construct complex structures and molecular …
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Designing 3D Wireframe DNA Nanoparticles for Programmable Innate Immune Activation
DNA nanotechnology harnesses the predictability and specificity of canonical base pairing interactions to enable the synthesis of complex DNA nanodevices capable of interacting with their environment in a controllable manner. Wireframe DNA origami are a class of highly customizable DNA …
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Nanopore-based Protein Sensing with DNA Nanostructures
… drives electrically charged molecules, like DNA, through the nanopore. As molecules move through the pore, the liquid containing the salt ions is displaced. The drop in liquid volume in the nanopore correlates to an increase in resistance and thus a drop in current. This current drop can …
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DNA Origami Structures for Artificial Light-Harvesting and Optical Voltage Sensing
In the past decade, DNA origami self-assembly has been widely applied for creating customised nanostructures with base-pair precision. In this technique, the unique chemical addressability of DNA can be harnessed to create programmable architectures, using components ranging from dye or protein …
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Rational Design of DNA-Based Lipid Membrane Pores
DNA nanotechnology has revolutionised our capability to shape and control three-dimensional structures at sub-nanometre length scales. In this thesis, we use DNA to build synthetic membrane-inserting channels. Porphyrin and cholesterol tags serve as membrane anchors to facilitate insertion into the …
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DNA Chemical Reaction Network Design Synthesis and Compilation
… engineering process for building and programming DNA-based computing devices. Contributions of this thesis include numeric abstractions for nucleic acid sequence and secondary structure, and a set of algorithms which employ these abstractions. The abstractions and algorithms have been implemented …
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DNA Constraints for Rational Control of Macromolecular Conformation
The DNA double helix is stable and rigid, making it an ideal nanoscale construction element. Duplex DNA has been used as a static framework to organize DNA, proteins, or nanoparticles, and dynamic DNA nanomachines have been built. However, assemblies in which DNA controls the intramolecular states …
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Development of intelligent stimuli-responsive biomaterials and nanodevices
<p>"Structural DNA nanotechnology utilizes DNA molecules as building blocks to fabricate ordered artificial nanostructures at the molecular level. Among all DNA-based techniques, DNA origami has been considered as one of the most powerful tools for constructing artificial nanostructures with …
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A computational model for the isothermal assembly of tiled DNA nanostructures
Complex DNA nanostructures have proven difficult to assemble from starting materials. Inefficient nanostructure assembly constitutes a barrier to the widespread use of DNA nanotechnology and is difficult to investigate experimentally due to the complicated nature of the assembly. This work …
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A synthetic lipid scramblase built from DNA
The programmable self-assembly facilitated by DNA nanotechnology provides unparalleled capabilities to construct functional devices at the nanoscale. Recently, DNA nanostructures have been developed to interact with biological membranes and serve as artificial counterparts of natural ion channels, …
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Sequence design principles for 3D wireframe DNA origami
DNA is a highly programmable molecule that can be designed to self-assemble into nearly arbitrary 2D and 3D nanoscale structures. DNA origami is a particularly versatile method to achieve complex molecular architectures. However, the rules for designing scaffolded DNA origami have not been …
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