Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"DNA G-quadruplex"”.
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DNA G-quadruplex structures in human cancer cells
DNA structures alternative to the double helix have emerged as key features of the genome for the understanding of genetics and diseases. In particular, G-quadruplexes (G4s), four-stranded structures formed in guanine-rich sequences of cellular chromatin, are implicated in transcription, …
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Investigating the function of DNA G-quadruplex structures in human enhancers
DNA molecules have the capacity to assemble and fold into topologically distinct molecular structures. DNA G-quadruplexes (G4s) are four-stranded DNA three-dimensional (3D) structures, that form in guanine-rich regions of the genome. G4s are enriched at sites of important regulatory potential in …
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Investigating DNA G-quadruplex structure function through genome and epigenome engineering
The importance of DNA secondary structures, such as four-stranded DNA G-quadruplexes (G4s), in genome function remains a largely unanswered question. G4s are implicated in transcriptional regulation; however, earlier studies are mostly correlative and do not directly address the role of an …
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Polarizable Simulations of the bcl-2 DNA G-Quadruplex and FMRP RNA G-Quadruplex:Duplex Junction Binding Protein
A G-quadruplex (GQ) is a type of noncanonical nucleic acid structure that can form in regions of nucleic acids rich in guanine nucleotides. The guanine bases form a square planar conformation via Hoogsteen hydrogen bonding. These stacked tetrads have inward-facing carbonyl oxygens, facilitating the …
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Design and synthesis of new potential anticancer agents and high-selective A2B antagonists
… this approach, psoralen derivatives, thought as DNA G-quadruplex stabilizers, were synthesized. For these compounds no biological assays were performed so far. Finally, the last part of the thesis has been dedicated to the synthesis of 1-alkyl-8-(piperazine-1-sulphonyl)phenyl xanthines as …
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Single-molecule G-quadruplex visualisation in live cells and 3D chromatin
The G-quadruplex (G4) is a secondary DNA structure formed by the self-assembly of guanine nucleotides. Mapping G4 formation in the human genome shows that they are enriched in functionally important regions such as promoters, enhancers, transcription factor and architectural protein binding sites. …
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Study of DNA damage on DNA G-quadruplexes and biophysical evaluation of the effects of modified bases (lesions) on their conformation and stability
<p>Exposure of DNA to reactive oxygen species (ROS) results in the modified nucleobases (lesions) as well as strand scissions under physiological conditions. Due to its lowest oxidation potential (1.29 eV), guanine is the most easily oxidisable nucleobase. Furthermore, it has been observed that the …
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Synthesis and use of new Porphyrin Derivatives
… interact with the anionic backbones of different DNA structures, displaying a different protonation degree depending on pH. The results obtained by CD-measurements, UV-Vis, fluorescence and RLS spectroscopy support the good ability of these derivatives (i.e. ZnTCPPSpm4) to act like inducer, probe …