Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"DNA Double-Strand Break Repair"”.
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The Role of 53BP1 in DNA Double-Strand Break Repair
<p>DNA double-strand breaks (DSBs) are dangerous insults to DNA integrity and can lead to genome instability if left unrepaired. However, the immune cell diversification reactions V(D)J recombination and Class Switch Recombination (CSR) require the formation of DSB intermediates, a process that is …
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DNA double-strand break repair studied by atomic force microscopy
DNA double-strand breaks (DSBs), where both strands of the DNA duplex are simultaneously fractured, are considered the most lethal type of DNA damage. The conserved Mre11-Rad50 DNA repair complex enables the catalytic activities of the Mre11 nuclease and the Rad50 ATPase to function together to …
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Studies of site-specific DNA double strand break repair in plants
… a site-specific DSB at the <i> Ds </i> locus for repair. Previous studies in maize and Arabidopsis showed that <i>Ac/Ds</i> excision can stimulate homologous recombination between tandem duplicated repeats and between ectopic homologies. In this study, we tested the efficacy of such <i>Ac/Ds</i> …
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Silencing, heterochromatin, and DNA double strand break repair in Saccharomyces cerevisiae
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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Single-molecule studies reveal mechanisms of human DNA double-strand break repair
DNA damage is ubiquitous to all organisms and very complex pathways have evolved to recognize and repair these lesions. The most deleterious DNA damages are double-strand breaks (DSBs), and a single unrepaired DSB can lead to cell death. In human cells, there exist two canonical pathways of DSB …
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Cell-Cell Junction Signaling Regulating DNA Double-Strand Break Repair In Breast Cells
… for epithelial cell malignancy in breast cancer. DNA double-strand break repair (DSBR) is one of the processes that get misregulated during breast cancer progression. In addition, radiation induced breaks such as those induced during radiation therapy to treat breast cancer patients are repaired …
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Effect of Werner and Bloom Helicase Deficiencies On Dna Double-Strand Break Repair
<p>DNA double strand breaks (DSBs) are very deleterious events that occur in cells. Causes can include endogenous agents such as reactive oxygen and nitrogen species, exogenous agents such as ionizing radiation and ultraviolet light, or other sources such as processing of spontaneous DNA lesions or …
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Targeting DNA Double-Strand Break Repair to Potentiate Radio- and Chemo Therapy of Glioblastoma
… resistance to TMZ was due to the augmented repair of TMZ-induced DNA double strand breaks (DSBs). TMZ induces DNA replication-associated DSBs that are repaired primarily by the homologous recombination (HR) pathway. We found that cell lines from recurrent cultures exhibited faster resolution …
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DNA-PKcs/ Artemis Complex in DNA Double-Strand-Break Repair: Cryo-EM and Biochemical Studies
DNA is the main carrier of inheritance and DNA damage will thus have serious consequences. DNA double-strand breaks (DSB) are amongst the most lethal forms of DNA damage. One DSB can lead to catastrophic consequences including cancer and cell death. To fix it, there are two main mechanisms-- …
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Identification and characterization of novel genes involved in DNA double strand break repair process in the yeast Saccharomyces cerevisiae
DNA Double Strand Break (DSB) is the most severe form of DNA lesion. Unrepaired DSBs and/or mutations in key DSB repair genes can lead to genomic instability, cancer or even cell death. DSBs can be repaired by two independent pathways; Homologous Recombination (HR) and Non-Homologous End Joining …
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Development of Novel Technologies to Investigate DNA Double-Strand Break Repair Uncovers a Role for the ATM Kinase in Error-Free NHEJ with Implications for Neurodegenerative Diseases
DNA double strand breaks (DSBs) are considered to be the most lethal genotoxic lesion because they can result in chromosomal translocations or result in a major loss of genetic information if repaired incorrectly. To preserve genomic integrity, mammalian cells have evolved a set of complimentary …
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Structural and biophysical analysis of Human DNA repair protein CtIP
… by endogenous and exogenous sources of DNA damage. The successful repair of DNA lesions is necessary for cellular survival and prevention of disease such as cancer. Therefore, complex molecular pathways have evolved to allow for accurate and timely DNA repair. It is now well-established …
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Identification of therapeutic targets and dependencies in ZNF703-amplified breast cancer
… lethal with loss of OTUD5, a regulator of DNA double strand break repair and interferon signalling. Furthermore, ZNF703 overexpression favours error-free repair of CRISPR-Cas9-induced double strand breaks and confers increased dependency on homologous recombination. Interactomic and …
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Crosstalk between DNA end resection and RNA metabolism
DNA suffers thousands of lesions from exogenous and endogenous sources. Nevertheless, double-strand breaks (DSBs) are the most dangerous form of DNA damage because if they are not properly repaired they can lead to mutations and genomic instability. In order to repair them, cells have developed two …
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The Protumorigenic Role of Caspase-8 in Neuroblastoma
… kinase (ATM), an essential mediator in the DNA double strand break repair mechanism, is activated by chemotherapeutic treatments, radiation, and cellular stress. Caspase-8 has one consensus phosphorylation site that has been reported to be phosphorylated in a genome-wide screen for ATM …
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ARTEMIS AND METNASE MEDIATED PROCESSING OF 3΄-BLOCKED DNA LESIONS: ROLE IN RADIO/CHEMORESISTANCE AND DNA REPAIR
<p>DNA double-strand breaks (DSB) with chemically modified end-termini are the most significant lesions resulting from radio/chemotherapeutic intervention of cancer and non homologous end-joining (NHEJ) factor Artemis nuclease has been implicated in the repair of such breaks. To examine whether the …
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Dissecting Molecular Mechanisms of Radioresistance Using in Vitro and in Vivo Brain Tumor Model Systems
… novel links between oncogenic signaling and DNA repair pathways. First, activation of the Akt pathway by EGFRvIII, a constitutively active form of EGFR, promotes DNA double strand break repair by non-homologous end joining in astrocytes and glioma cell lines. This results in faster repair and …
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RADIOSENSITIZING EFFECTS OF THROMBIN PEPTIDE TP508 ON MEDULLOBLASTOMA CANCER STEM CELLS
… focused on investigating the effects of TP508 on DNA double-strand break repair mechanisms. Results showed that TP508 significantly sensitizes medulloblastoma CSCs to RT by inhibiting activation of DNA repair molecule, BRCA1, involved in homologous recombination, and by downregulating the …
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Novel Protein-protein Interactions Regulate The Proteolytic Activity Of The Pro- Apoptotic Serine Protease, Omi/htra2
… Omi interactors. I screened a human melanocyte cDNA library using the yeast-two-hybrid system and Omi as the "bait" protein. Human Rad21 protein was isolated as a specific novel interactor of Omi. Human Rad21 interacted with the PDZ domain of Omi, the part of the protein known to be involved in …
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Functional significance of unique sequences in Mycobaterium smegmatis Ku proteins
… to the non-homologous end-joining pathway of DNA double strand break repair, first discovered in eukaryotes and more recently in prokaryotes and archaea. This study concerns the importance of two unique sequence features of Ku protein from Mycobacterium smegmatis that include a lysine-rich …
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