Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"DNA Crosslink repair"”.
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DNA crosslink repair safeguards genomic stability during pre-meiotic germ cell development
… endonuclease XPF-ERCC1 in Fanconi-mediated DNA crosslink repair during germ cell development in utero. Inactivation of Fanconi-mediated DNA repair results in an almost complete loss of gamete production in mice. This repair pathway is critical for the normal development of primordial germ …
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Fanconi Anaemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mammalian development
… are usually transcriptionally silenced with both DNA methylation and chromatin modification playing critical roles in restricting LINE-1. Germline-specific restriction factors, such as the piRNA, are critical to restrict LINE-1 retrotransposition preventing the acquisition of novel integrations …
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Novel Microsatellite Detection, Microsatellite Based Biomarker Discovery In Lung Cancer And The Exome-Wide Effects Of A Dysfunctional DNA Repair Mechanism
… for aiding in the completion of the euchromatic DNA. We also developed a disease risk diagnostic using a novel target specific enrichment method that produces high resolution MST sequencing data that has the potential to validate, for the first time, the link between MST genotype variation and …