Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"DNA Copy Number Changes"”.
-
Computational Analysis of Genome-Wide DNA Copy Number Changes
DNA copy number change is an important form of structural variation in human genome. Somatic copy number alterations (CNAs) can cause over expression of oncogenes and loss of tumor suppressor genes in tumorigenesis. Recent development of SNP array technology has facilitated studies on copy number …
-
Bayesian Hidden Markov Models for finding DNA Copy Number Changes from SNP Genotyping Arrays
DNA copy number variations (CNVs), which involve the deletion or duplication of subchromosomal segments of the genome, have become a focus of genetics research. This dissertation develops Bayesian HMMs for finding CNVs from single nucleotide polymorphism (SNP) arrays. A Bayesian framework to …
-
Hidden Markov Model inference copy number change in array-CGH data
… instability frequently resulting in genomic changes involving DNA copy number gains or losses. Identifying the genomic location of these regional alterations provides important opportunities for the discovery of potential novel oncogenes and tumor suppressors. Recently, array based …
-
Detection and Characterization of Multilevel Genomic Patterns
DNA microarray has become a powerful tool in genetics, molecular biology, and biomedical research. DNA microarray can be used for measuring the genotypes, structural changes, and gene expressions of human genomes. Detection and characterization of multilevel, high-throughput microarray genomic data …
-
Modeling and Characterization of Dynamic Changes in Biological Systems from Multi-platform Genomic Data
… models that characterize such dynamic changes in biological systems is one of the key objectives in bioinformatics and computational biology. Recent advances in high-throughput genomic and molecular profiling technologies such as gene expression and and copy number microarrays provide …