Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 743 for “"DNA Binding"”.
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DNA binding economies
… regulation. Genetic regulation determines how DNA is read and interpreted, is responsible for cell specialization, reaction to drugs, metabolism, etc. Improved understanding of regulation has potential to impact research on genetic diseases including cancer. Genetic regulation relies on …
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Polymers for DNA Binding
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Calling Cards For DNA-Binding Proteins
… by transcription factors, which bind to specific DNA sequences near genes. In order to understand the regulatory networks that control transcription, the genomic targets of all transcription factors under various conditions and in different cell types must be identified. This remains a distant …
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The DNA Binding Protein Lsr2 from Mycobacterium tuberculosis
Lsr2 is a small, basic DNA binding protein that is highly conserved in mycobacteria and related actinomycetes. Lsr2 is essential for growth in Mycobacterium tuberculosis and previous studies have shown that Lsr2 is involved in down-regulating a wide range of genes involved in cell wall synthesis …
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Characterization of DNA Binding Activities at Vertebrate Telomeres
… factors that either bind directly to telomeric DNA or that are recruited there by DNA binding activities. Thus, telomeric DNA binding activities are central to telomere function. Two types of vertebrate DNA binding activities are characterized in this thesis: proteins that can potentially bind …
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P22 arc--energetics and cooperativity of DNA binding
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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Analysis of DNA-binding Proteins in Yeast Saccharomyces Cerevisiae
… organisms now readily available, a plethora of DNA functional elements have been predicted, but the process of identifying the proteins that bind to them in vivo remains a bottleneck. I developed two high-throughput assays to address this issue. The first is a modification of the yeast …
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Exploring the dynamic landscape of small molecule-DNA binding
Deoxyribonucleic acid (DNA) is a fundamental component in all living organisms found in Nature. Although both the double-helix structure of this biomolecule and the fact that it stores all the genetic information required by the organism to survive are well understood there are still aspects …
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Mechanical Manipulation of Eukaryotic Chromatin by DNA-Binding Proteins
… serves to exert spatiotemporal control of many DNA-transacting processes such as gene expression. Despite emerging progress, the biophysical mechanism underpinning eukaryotic genome organization remains an outstanding question in the field. In this thesis, I describe mechanistic insights on …
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Fret Studies of DNA Binding By Lambda Cro Variants
Proteins bind to DNA to form switches and circuits that control the flow of genetic information from DNA sequence to the physical components of cells and organisms. The dynamic performance of genetic switches depends on the coupling of the comprocesses of transcription and translation to …
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Structural Studies of Two Sequence-General DNA -Binding Proteins
On the other hand, ssDNA-protein interaction is far less well understood than dsDNA-protein interactions. Gene V proteins from the filamentous phages are excellent systems for studying the interactions between protein and ssDNA. Some high resolution crystal structures were determined already. The …
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A molecular dynamics study of hormone receptor-DNA binding
… simulations are utilized to investigate the binding of hormone receptors to DNA. The hormone receptors constitute a family of gene regulatory proteins that can be divided into two subfamilies based on the sequence of DNA to which a receptor binds with high affinity. The glucocorticoid …
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Topologically constrained DNA intercalators: Synthesis and DNA binding studies
The synthesis and DNA binding properties of three macrocyclic diacridines (31, 32 and 33) is discussed. The two acridines are connected by linker chains at the 4- and 9-positions. Macrocycles 31 and 32 are linked via spermine at the 9-position and have been shown to bind to DNA by bisintercalation …
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Designing Novel DNA-Binding Proteins with Generative Deep Learning
Protein-DNA interactions play a critical role in various biological processes, such as gene regulation and genome maintenance. Designing protein backbones specifically tailored for DNA binding remains a challenging task, requiring the exploration of novel computational approaches. This thesis …
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P22 arc repressor : cooperative DNA binding and transcriptional regulation
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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NMR Studies on Kinetics of Processes Involving DNA-Binding Proteins
… function. In response to external stimuli, DNA binding proteins very efficiently carry out their cognate tasks by making use of different kinetic mechanisms. Here we quantitatively analyze the kinetics of various processes involving DNA binding proteins. Chapter I provides an introduction to …
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Synthesis and DNA-binding studies with two stericallyfriendly porphyrin frameworks
… porphyrins play a significant role during binding with DNA hosts. Possible applications of these systems in photodynamic therapy as well as in anti-bacterial and anti-cancer therapies motivate the binding studies. For characterizing DNA binding motifs different methods are useful including …
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