Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"DNA, Mitochondrial"”.
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Restriction fragment length polymorphism analysis of chloroplast DNA, mitochondrial DNA, and ribosomal DNA in turfgrasses
… length polymorphisms (RFLPs) of chloroplast DNA (cpDNA), mitochondrial DNA (mtDNA), and ribosomal DNA (rDNA), were used to estimate and compare the extent of diversity among the organellar and nuclear genomes, and to infer species relationships. Eight cultivated turfgrass species and …
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Mitophagy in Heart Failure: A Selective Autophagic Degradation of Mitochondria
… disease is associated with declines in mitochondrial function. Autophagy is a lysosomal-dependent process through which cytoplasmic proteins and organelles can be degraded and has recently been shown to participate in remodeling of the myocardium in a variety of cardiac pathologies. …
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Consequences of Pathogenic Mitochondrial DNA Mutations in Cancer Progression
Mitochondrial DNA (mtDNA) mutations are prevalent in human cancers; however, their functional impact on cancer progression remains controversial and uncertain. This uncertainty is primarily due to a lack of suitable models for controlled functional studies. This thesis addresses this limitation by …
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Mitochondrial DNA in ancient human populations of Europe.
… in the nonrecombining maternally inherited mitochondrial DNA has been studied in a wide array of modern populations in order to reconstruct the migrations that have participated in the spread of our ancestors on the planet. However, population genetic processes (e.g., replacement, genetic …
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Identifying Metabolic Liabilities in Hürthle Cell Thyroid Carcinoma
… activity, most forms of cancer rely on mitochondrial respiration for tumor growth. Hürthle cell carcinoma of the thyroid (HTC) represents an outlier wherein HTC tumors enrich for mitochondrial DNA mutations that are predicted to impair complex I of the electron transport chain (ETC). …
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Metabolic Reprogramming in Response to Mitochondrial Electron Transport Chain Dysfunction
Mitochondrial electron transport chain (ETC) diseases are genetic disorders of energy production with an occurrence rate of approximately 1:4300 and no effective treatment options. Here we show in vitro models of mitochondrial ETC dysfunction display shunting of major carbon sources (glucose and …
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Ancient DNA from pre-Columbian South America
Ancient DNA (aDNA) research in the Americas represents a genetic strategy to investigate demographic and historical events of populations in the continent with the added bonus of having a direct and temporal perspective. This thesis aims to explore human mitochondrial DNA (mtDNA) diversity from a …
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Mitochondrial DNA Copy Number, Insulinemic Potential of Lifestyle, and Colorectal Cancer
… containing an independent genome, i.e., mitochondrial DNA (mtDNA). It has been increasingly recognized that mtDNA copy number (mtDNAcn) is a biomarker for mitochondrial function and cellular oxidative stress. To date, the few studies that have assessed associations between mtDNAcn and CRC …
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Investigating the role of circulating cell-free dna as a mechanistic biomarker in inflammatory bowel disease: development of an integrated precision-medicine enabled platform in Scotland
BACKGROUND: Circulating cell-free DNA (cfDNA) represents a class of biological molecules whose role in inflammation remains poorly understood. Inflammatory bowel disease (IBD), from ulcerative colitis to Crohn’s disease, comprises a spectrum of chronic immune-mediated conditions with complex …
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Role of Mitochondrial Dynamics and Autophagy in Removal of Helix-Distorting Mitochondrial DNA Damage
… to translate these proteins. Over 300 pathogenic mitochondrial DNA (mtDNA) mutations have been shown to cause a number of mitochondrial diseases emphasizing the importance of mtDNA maintenance and integrity to human health. Additionally, mitochondrial dysfunction and mtDNA instability are linked …