Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"DMXL1"”.
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Functional and Mechanistic Analysis of Protein Degradation by Human Cytomegalovirus to Uncover Viral Immune Evasion Mechanisms
… pseudokinase (MLKL) and DmX-like protein 1 (DMXL1), were then selected for further mechanistic and functional characterisation. MLKL is the terminal effector of a form of cell death called necroptosis. Many herpesviruses suppress necroptotic signalling to evade cell death. However, the …
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Characterisation of Novel Autophagy and Necroptosis Antagonists Encoded by Human Cytomegalovirus
… acidification proteins, Dmx-like protein-1 (DMXL1) was identified as the only factor that regulates vacuolar acidification and is also targeted for degradation by HCMV. Systematic analysis of viral deletion mutants revealed that the uncharacterised 7 kDa protein US33A is both necessary and …
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Genetic basis of inherited kidney and related tumours
… Five additional novel candidate genes (*CTTN*, *DMXL1*, *MUC17*, *GANAB* and *DET1*) were identified in other probands, all with missense *de* *novo* variants, which require validation in larger cohorts and/or additional functional studies to definitively determine their pathogenicity and …