Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"DMBA-TPA"”.
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The Regulation of Oncogenic MAP Kinase Signalling by Dual-Specificity MAP Kinase Phosphatases
… suppressor function in the murine model of DMBA/TPA-induced skin carcinogenesis. We also show that the endogenous expression of mutant KRasG12D in murine fibroblasts induces the expression of both DUSP5 and DUSP6/MKP-3, suggesting these proteins are involved in the negative feedback …
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Gain-of-Function Mouse Models to Investigate Biological Roles of Prmt6
… subjected to skin carcinogenesis study using the DMBA/TPA system and to a p53+/- genetic cross. The MMTV-cre crossed mice have been subjected to ageing studies. I have also performed RNA-seq experiments on primary mammary epithelial cells from the MMTV-Cre crossed mice.</p> <p>In conclusion, this …
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
… with 12-O-tetradecanoylphorbol-13-acetate (TPA), old cell morphology starts to change young cell like in addition to molecular markers of cellular senescence, such as increases of DNA synthesis, pRB hyperphosphorylation, reductions of p53, p21Sdi1/WAF1/CIP1 and SA-β-galactosidase activity. …
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Generation and characterization of novel mouse models to validate the role of KLK5 protease in inflammation for pharmacological applications
… induced in wt and Klk5-/- mice by application of DMBA/TPA or DMBA/DMBA according to established protocols. We show that Klk5-/- mice are resistant to early skin tumorigenesis. By contrast, the significantly fewer tumors that developed in Klk5-/- skin progressed faster to premalignant and malignant …