Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"DLK"”.
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A DLK And JNK Dependent Axon Self-Destruction Program Promotes Wallerian Degeneration
… We demonstrate that dual leucine kinase: DLK) promotes degeneration of severed axons in Drosophila and mice, and its target JNK promotes degeneration locally in axons as they commit to degenerate. This pathway also promotes degeneration after chemotherapy exposure, and thus may be a …
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Investigating The Role of Pancreatic eIF2-alpha kinase (PEK) In DLK/ Wallenda (Wnd)-mediated Neurodegeneration In Drosophila
… kinase (PEK) and the Dual Leucine Zipper Kinase (DLK) signaling kinase Wallenda (Wnd) are important regulators of neuronal health and neurodegeneration. Although these two (2) kinases are very important, their interaction in degenerative and regenerative responses are not fully understood. …
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Identifikation einer funktionellen Kernerkennungssequenz in der Dual-Leucine-Zipper-Bearing Kinase
… führt. Die als JNK-Aktivator be-schriebene DLK ist sowohl in die Induktion von Apoptose in Neuronen und Beta-Zellen als auch in die Hemmung von CREB involviert. In der vorliegenden Arbeit sollte zum einen die Frage nach der subzellulären Lokalisation der DLK geklärt werden. Zum anderen …
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Wirkung der proinflammatorischen Zytokine TNFα und IL-1β auf die Aktivität und die Proteinmenge der Dual-Leucine-Zipper-Bearing Kinase in einer Betazelllinie
… noch nicht vollständig geklärt ist. Die MAP3K DLK ist eine wichtige Komponente in der Regulation des programmierten Zelltodes, da sie neben der Aktivierung der JNK mit ihren proapoptotischen Einflüssen auch den Transkriptionsfaktor CREB inhibiert, wodurch dessen antiapoptotische Funktion …
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The molecular mechanism of Dual leucine zipper kinase protein localization in neuronal stress signaling.
… and survival. Dual Leucine Zipper Kinase (DLK) modulates neuronal stress responses, including neuronal loss implicated in various neurodegenerative conditions. DLK is axonally expressed and is under constant suppression under normal conditions. Although DLK is known to localize in axons and …
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Identification of motifs in the tribbles kinase required for substrate interactions
… domain, which includes a conserved catalytic DLK motif needed in normal kinases to mediate phosphotransfer during kinase-substrate interactions. Genetic misexpression assays in the fly eye and wing were used to confirm Trbl suppression of Slbo phenotypes and to determine the essential nature …
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Regulatory Proteins in Progenitors and Differentiated Cells of the Human Prostate
… the putative suppressor of differentiation Dlk-1. We also supply evidence that nuclear Notch-1 activity down-regulates the candidate SC marker Dlk-1 in differentiating glandular precursor cells, that Notch-signalling regulates proliferation of precursor cells, and that inactive Notch-1 is a …
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Transition from integrable to chaotic domain in spectra of spin chains
… B and the Kullback–Leibler divergence DLK(PW−D(s)|Pdata(s)), where PW−D(s) and Pdata(s) are the Wigner-Dyson and the system’s spacing distribution respectively. The B coefficient is associated to a sequence of events in the system. The Kullback–Leibler divergence provides information on …
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Retrograde Activation of a Somatic Transcriptional Program Regulates Distal Axon Degeneration
… in loss of Akt signaling and activation of DLK signaling, leading to activation of the JNK/c-jun signaling and a Foxo3a dependent transcriptional program. The cell body acts as a convergence point for these two pathways resulting in upregulation of the proapoptotic protein Puma, itself …