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Showing 1 to 20 of 21 for “"DLB"”.

  1. Dementia with Lewy bodies —an Investigation of Cause and Consequence

    Boström, FredrikClinical Memory Research Unit, Lund University2009

    Dementia with Lewy bodies (DLB) is today considered to be the second most common primary neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are …

    lund Repository record

  2. A study of ultra-high field strength structural and spectroscopic MR imaging in dementia with Lewy bodies and Alzheimer’s disease

    McKiernan, ElizabethUniversity of Cambridge2025

    … dementia, dementia with Lewy Bodies (DLB) is relatively poorly understood, with little research focusing on its pathophysiology or symptomatology in comparison with Alzheimer’s disease (AD) or Parkinson’s disease (PD), to which it is closely related. In contrast to AD, which typically …

    cambridge Repository record

  3. The automatic implementation of a dynamic load balancing strategy within structured mesh codes generated using a parallelisation tool

    Rodrigues, Jacqueline NadineUniversity of Greenwich2003

    … implementation of a dynamic load balancing (DLB) strategy within a parallel SPMD (single program multiple data) structured mesh application code is possible. It details how DLB can be effectively employed to reduce the level of load imbalance in a parallel system without expert knowledge of …

    greenwich Repository record

  4. The Role of β-synuclein in the Pathological Mechanisms of Dementia with Lewy Bodies

    Evans, Tracey2018

    Dementia with Lewy bodies (DLB) is the second most prevalent neurodegenerative dementia following Alzheimer’s disease (AD). DLB neuropathology is characterised by Lewy bodies (LBs) and Lewy neurites (LNs) resulting from the modification and aggregation of α-synuclein. The presence of small …

    plymouth Repository record

  5. Lewy Body Dementia and the Role of Inflammation

    Surendranathan, AjenthanUniversity of Cambridge2018

    … dementia (PDD) and dementia with Lewy bodies (DLB), is known to make up more than 15% of dementia cases at autopsy, however the clinical prevalence rate is reported to be much lower at around 5-6%. Difficulties with diagnosis and/or lack of specific treatments may contribute to this difference. …

    cambridge Repository record

  6. Phase-based adaptive dynamic load balancing for parallel tree computation

    Haron, FazilahUniversity of Leeds1998

    Dynamic load balancing (DLB) is a technique for the parallel implementation of problems which generate unpredictable workloads by migrating work units to lightly loaded processors based on run-time workload measurement. Adaptive DLB is a refinement where aspects of the load balancing system itself …

    whiterose Repository record

  7. Alzheimer's disease and dementia with Lewy bodies: Special focus on the role of serpins

    Nielsen, HenriettaChronic Inflammatory and Degenerative Diseases Research Unit2007

    … disease (AD) and dementia with Lewy bodies (DLB). The pathological characteristics of AD include senile plaques, mainly composed of aggregated amyloid-beta peptide (Abeta1-42), but also serpins, and neurofibrillary tangles of hyperphosphorylated tau protein. Pathological hallmarks of DLB …

    lund Repository record

  8. Early hippocampal dysfunction in a mouse model of dementia with Lewy bodies: Mechanisms of cellular dysfunction caused by alpha-synuclein accumulation

    Cowan, Katrina2020

    Dementia with Lewy bodies (DLB) is a devastating neurodegenerative disease, accounting for 5% of all dementia cases, for which there is no cure. Whilst there are currently many different animal models currently available for researchers studying PD, there are comparatively fewer DLB-specific mouse …

    plymouth Repository record

  9. Markers of Prognosis in Neurodegenerative Dementia

    Stubendorff, KajsaClinical Memory Research Unit, Lund University2014

    … types of neurodegenerative dementia; AD and DLB/PDD. Study populations: I. 142 patients with AD. II. 79 patients with AD and 49 patients with DLB. III. 30 patients with DLB/PDD. IV. 32 patients with DLB PDD. Results: I. Patients with very high T-tau levels performed worse on cognitive tests …

    lund Repository record

  10. The role of Ubiquitin ligases Nedd4-1 and Nedd4-2 in the brain and their crosstalk with alpha-synuclein and other dementia-related proteins

    Conway, James2024

    … disease (PD) and Dementia with Lewy Bodies (DLB) are a progressive and currently incurable neurodegenerative disease and the most common movement disorder. α-synuclein protein is thought to be the main aetiological agent of PD and DLB, particularly when levels are increased in substantia …

    plymouth Repository record

  11. Validation of brief cognitive tests in mild cognitive impairment, Alzheimer's disease and dementia with Lewy bodies.

    Palmqvist, SebastianClinical Memory Research Unit, Lund University2011

    … II. 33 patients with dementia with Lewy bodies (DLB) and 66 with AD. III. 75 patients with AD. IV. 99 patients with mild cognitive impairment (MCI). Findings I. Cube copying was found useful for evaluating treatment with acetylcholinesterase inhibitors (AChEI) in patients with AD. II. Easy and …

    lund Repository record

  12. Differential expression of proteins involved in sEV biogenesis and secretion in Parkinson’s disease and Dementia with Lewy bodies

    Sahoo, Anis2025

    … disease (PD) and dementia with Lewy bodies (DLB).<br/><br/>Aims<br/>1. In this study I aim to measure levels of key sEV proteins by focusing on disease-specific brain regions such as the substantia nigra and hippocampus of patients with PD and DLB compared to healthy control …

    plymouth Repository record

  13. Alpha Synuclein Oligomers in Human Pathology: Significance of Nitrative Alpha Synuclein Modifications

    Martin, Zane 1975-The University of Texas Medical Branch at Galveston2016

    … disease (PD) and dementia with Lewy bodies (DLB), which are clinically characterized by motor and cognitive dysfunction. Recent evidence indicates that αSyn oligomer intermediates are the most neurotoxic species. However, the mechanism of action of αSyn oligomers remains elusive. Previous …

    utmb Repository record

  14. Dementia Subtypes, Cognitive Decline and Survival Among Older Adults Attending a Memory Clinic in Cape Town, South Africa: A Retrospective Study

    Ssonko, MichaelDepartment of Medicine2023

    … (VND), 6(3.6%) Dementia with Lewy Bodies (DLB), 5(3%) Parkinson disease-associated dementia (PDD), 3(1.8%) fronto-temporal dementia, 4(2.4%) mixed dementia and 6(3.6%) other types of dementia. The average annual decline in MMSE points was 2.2(DLB/PDD), 2.1(AD) and 1.3(VND). Cognitive scores …

    cape-town Repository record

  15. Investigating the Potential Role of α-Synuclein in Tau Aggregation and Toxicity

    Sengupta, UrmiThe University of Texas Medical Branch at Galveston2020

    … disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA), LBs and LNs have been reported in Alzheimer’s disease (AD) patients as well. Both α-Syn and tau can exist as polymorphic aggregates, and this phenomenon has been widely studied, mostly in their fibrillar …

    utmb Repository record

  16. Das zelluläre Prionprotein im Liquor cerebrospinalis von Patienten mit verschiedenen neurologischen Erkrankungen

    Meyne, Felix2012

    … einer Erkrankung für die Gruppen CJK, AD, DLB und NPH dargestellt werden. Alters-, geschlechts- sowie im Falle der CJK Genotypspezifische Faktoren scheinen auf die Regulation des Prionproteins Einfluss zu nehmen. PrPc könnte ähnlich der bereits klinisch etablierten Biomarker Aβ1-42 und …

    goettingen Repository record

  17. The role of germline and somatic nuclear and mitochondrial DNA variation in neurodegenerative disorders

    Keogh, MichaelUniversity of Cambridge2018

    … risk of developing dementia with lewy bodies (DLB) and Alzheimer’s disease (AD) respectively. Secondly, we detected a previously unknown systematic bias in the interpretation of oligogenic interactions with implications for our understanding of disease mechanisms and coexistent clinical …

    cambridge Repository record

  18. MCI IN RBD as a Distinct Clinical Entity: Comparative Evaluation of Diagnostic Frameworks and the cognitive domain as predictive factors of phenotypic conversion

    MULAS, MARTINAUniversità degli Studi di Cagliari2026

    … disease (PD) or dementia with Lewy bodies (DLB). Individuals with isolated RBD (iRBD) frequently exhibit subtle but measurable cognitive alterations that may reflect the initial spread of pathology. Neuropsychological changes are often concomitant in this population: numerous studies have …

    cagliari Repository record

  19. Studies on the Cytoplasmic Inclusions Detected in Parkinson's disease

    류, 명이2011

    … disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Synphilin-1, interaction partner of α-Synuclein is a major component of inclusion bodies, but it is unknown how synphiln-1 contributes to the cellular and biochemical mechanisms of PD, and its normal …

    ajou Repository record

  20. Development and utilization of Luminex biomarker assays for diagnosis and monitoring of neurodegenerative disease

    Ismail, Kurimun, Allsop, DavidLancaster University2016

    … disease (PD), dementia with Lewy bodies (DLB), fronto-temporal lobar degeneration (FTLD), motor neuron disease (MND), Huntington’s disease and the prion diseases. The incidence and prevalence of most of these diseases is rising, especially those that cause dementia, due to an increase in …

    lancaster Repository record

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