Global ETD Search
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Showing 1 to 1 of 1 for “"DKK1/E-cadherin feedback"”.
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The Role and Control of WNT Signalling in an HESC Model of Human Primitive Streak
… CRISPR/Cas9 knockout lines, I discovered that DKK1 and E-CADHERIN were the two dominant factors, with E-CADHERIN transducing boundary forces to focus WNT signalling to colony border at early times, and DKK1 controlling the late WNT pattern via cell non-autonomous negative feedback. With the …