Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"DJ-1"”.
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Cell model of DJ-1-associated Parkinson’s Disease
… in PARK7, a gene which codes for the protein DJ-1. While there are many proposed roles of DJ-1 across numerous systems, the function of DJ-1 in relation to the development and progression of PD remains largely unclear. A first step towards determining this function is the creation of …
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Structure-function studies of the Parkinsonism-linked protein DJ-1
DJ-1 is a multifunctional protein linked to familial Parkinson’s disease. DJ-1 has been suggested to exert its cytoprotective function, in part, by acting as a copper carrier that can sequester the reactive metal and/or provide the copper cofactor for the activation of the Cu-Zn superoxide …
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DJ-1 AND ATP13A2: TWO PROTEINS INVOLVED IN PARKINSON’S DISEASE
… ATP13A2, a lysosomal ATPase; and PARK7, encoding DJ-1, a protein with proposed antioxidant and chaperone activities. Understanding the biochemical mechanisms underlying the neuroprotective functions of DJ-1 and mechanistic details accounting for functional overlap between ATP13A2 and DJ-1 can …
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Regulation of Astrocyte Functions by a Parkinson's Disease Gene, DJ-1
… (PD) 1 B. Genes associated with PD . 2 1. DJ-1 (PARK7) 2 2. Other genes . 3 C. Function of astrocytes in the normal brain . 6 D. Function of astrocytes in the injured brain . 7 1. Reactive astrocytes : intermediate filaments (Ifs) and morphological features . 7 2. Reactive astrocytes : …
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Behavioral, Neurochemical, and Histological Characterization of Mice Deficient for Parkin, DJ-1, and Antioxidant Proteins
… gene. Loss-of-function mutations in parkin and DJ-1 were the first to be linked to recessively inherited parkinsonism. Surprisingly, mice bearing similar loss-of-function mutations in parkin and DJ-1 do not show age-dependent loss of nigral dopaminergic neurons or depletion of dopamine in the …
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DJ-1, a Parkinson’s Disease-associated Gene, Prevent Excessive Glial Inflammatory Responses through Interaction with SHP-1
… study, I demonstrate a novel mechanism by which DJ-1 (PARK7), an early onset autosomal recessive PD gene, negatively regulates inflammatory responses of astrocytes and microglia by facilitating the interaction between STAT1 and its phosphatase, SHP-1 (Src-homology 2-domain containing protein …
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Surprising Behavioral and Neurochemical Enhancements in Mice with Combined Mutations Linked to Parkinson's Disease
… humans lacking expression of either Parkin or DJ-1 develop PD. However, one limitation to studying PD is a lack of rodent models that recapitulate both the dopaminergic and motor symptoms as well as the age-dependent development of this disease. In fact, mice deficient for either one or both …
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Regulation of the redox homeostasis during polyglutamine misfolding in Huntington’s Disease
… the role of the redoxactivatable chaperone DJ-1 in HD was investigated. Protein expression analysis in HD cell models, a rodent model of HD and human HD brain samples showed an up-regulation of DJ-1 protein expression compared to control samples. Oxidation of DJ-1 was also elevated<br/>in …
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Deciphering the role of Hsp31 as a multitasking chaperone
… familial form of PD including PARK7 that encodes DJ-1. DJ-1 is a member of ThiJ/DJ-1/PfpI protein superfamily that are the quintessential multitasking or moonlighting protein family as evidenced by their involvement in multiple cellular functions including oxidative stress sensing, protein …
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Structural Investigations of Nematode Anhydrobiotic and Rab11-FIP Proteins by Far-UV Circular Dichroism and Mid-IR Fourier Transform Infra-Red Spectroscopy
… A second nematode anhydrobiotic protein (P. sup DJ-1) was found to be structurally very similar to the human DJ-1 homolog and exist as an a/b-mixed b- sandwich protein. Stability studies revealed that P. sup DJ-1 showed considerable temperature stability, both in terms of its helix domains and …
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Neuroprotective Effects of Sulforaphane and the Involvement of Autophagy
… (6-OHDA) induced cell death. Further, DJ-1, a multifunctional protein, was selected for investigation with SFN, since it is highly implicated with neuronal cell health. SFN induced DJ-1 protein levels dose-dependently. In addition, tunicamycin-induced ER-stress was significantly reduced …
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Analisi Molecolare del Melanoma
… 65 kDa regulatory subunit A ¿ isoform, protein DJ-1, cyclophilin A and cofilin-1. We show, for the first time, that only specific isoforms of these molecules are overexpressed in melanoma. Different protein profiles were also found between each individual melanoma cell line and the melanocytes. …
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Development and utilization of Luminex biomarker assays for diagnosis and monitoring of neurodegenerative disease
… α-synuclein, total α-synuclein, total DJ-1 and LRRK2 in human CSF and plasma. These proteins are predominantly implicated in diseases collectively termed α-synucleinopathies. The initial aim of the project was to develop assays for proteins that span a range of neurodegenerative …
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Loss of function of Gene X protects against α-dicarbonyl stress through the skn-1 pathway in C. elegans
… glyoxalase system (<em>GLO1</em> and <em>DJ-1</em>) in humans. Utilizing the conserved glyoxalase system, we were able to establish within a <em>C. elegans </em>model that when this glyoxalase system is impaired, the damages of α-dcs are reminiscent of diabetic complications. A recent …
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The localization of UCH-L1(Ubiquitin C-terminaHydrolase-L1) in lipid rafts of neuronal cell
… such as α-synuclein, LRRK2, PINK1,Parkin and DJ-1 as well as AD-associated gene, amyloid-β, Prion's disease-associated gene, prion and HD-associated gene, huntingtin may play important roles in lipid rafts. The functional alteration of lipid rafts by these proteins may be one of common …
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Isolation and functional analysis of differentially expressed genes in human prostate cancer
… A, RNA-binding protein regulatory subunit DJ-1 protein und V-ATP Synthase Untereinheit F), die eine hochregulierte Expression in menschlichen Prostatakarzinomen zeigten, die Überexpression in Prostatakrebs mittels real time RT-PCR an Gesamttumor-RNA bestätigt. Die Überexpression von …