Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"DISC1"”.
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NDE1 in the DISC1 pathway: interactions of schizophrenia-related proteins
The Disrupted-In-Schizophrenia 1 (DISC1) gene is one of the most established risk genes for psychiatric illness currently being studied, having originally been identified as being directly disrupted by a balanced chromosomal translocation that cosegregates with schizophrenia and other major mental …
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Effect of rare and common single amino acid substitutions on DISC1 subcellular targeting and functional interaction with ATF4
DISC1, a strong genetic candidate for psychiatric illness, is a molecular scaffold residing in multiple subcellular compartments, where it regulates the function of interacting proteins with key roles in neurodevelopment and plasticity. Both common and rare DISC1 missense variants are associated …
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Investigating putative pathogenic mechanisms within a family in which a chromosomal translocation confers risk of major mental illness
… disrupts Disrupted-in-Schizophrenia-1 (DISC1) and DISC2 on chromosome 1, and DISC1FP1 (Disrupted-in-Schizophrenia-Fusion-Partner-1), also known as Boymaw, on chromosome 11. DISC1 is a leading candidate gene for major mental illness and is involved in neurodevelopment and cellular …
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Aberrant assembly and function of a hippocampal circuit in a genetic mouse model of schizophrenia
… to the disease. Disrupted in Schizophrenia 1 (DISC1), was first discovered in a family with a balanced translocation t (1; 11) (q42; q14) and a history of psychiatric disease that segregates with the translocation. We created the Disc1Tm1Kara mice, an etiologically valid genetic mouse model …
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Converging biochemical pathways in psychiatric disorders
… the mechanisms of transcriptional repression by DISC1 on ATF4-mediated gene transcription. The second project presents some initial steps towards uncovering the role of BCL9 in neuronal development.
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CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL
… such as the disrupted gene in schizophrenia (DISC1). I found that FGF14 might bind DISC1 in a recombinant system and native mouse brain tissue. Disruption of this binding might be involved in the alterations of adult neurogenesis in Fgf14−/− mice. Another possible mechanism is the changes in …
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Effect that the t(1;11) translocation and mental disorders have on glutamate and NAA levels in the prefrontal lobe, as measured by MRS
… t(1;11)(q42.2;q14) translocation that affects DISC1 have a substantially raised risk of developing a range of mental disorders, including bipolar affective disorder, schizophrenia and depression. A genetic change that leads to an increase in the susceptibility to a range of mental disorders is …