Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"DIRECT COMPRESSION"”.
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Engineering composite particles to overcome the poor pharmaceutical performance of paracetamol
… and tamper–proofness in comparison to capsules. Direct compression is the favoured smart choice for tablet manufacturing. The advantages of direct compression: include simplicity, reduced time and the final cost of the product due to fewer processing stages, continuous nature, and elimination of …
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Desenvolvimento de antisséptico bucal em pastilha para prevenção da cárie dental
… containingcetylpyridinium chloride (CPC), using direct compression technology. Therefore, theanalysis of pharmaceutical excipients and the evaluation of the characteristics of theformulations were carried out. A preformulation study was carried out to assess thecompatibility of the active …
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Design of oral insulin tablet formulations to enable manufacture and storage under ambient conditions
… tablet manufacturing techniques, such as direct compression, expose peptides to mechanical, thermal, and hygroscopic stresses with the potential to accelerate degradation. In contrast, lyophilisation (freeze-drying), a low-stress process commonly used in parenteral formulations, enables …
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ΑΝΑΠΤΥΞΗ ΤΕΧΝΙΚΩΝ ΓΙΑ ΤΗ ΒΕΛΤΙΩΣΗ ΤΗΣ ΠΟΙΟΤΗΤΑΣ ΤΩΝ ΔΙΣΚΙΩΝ ΚΑΙ ΤΗΝ ΑΠΟΔΕΣΜΕΥΣΗΦΑΡΜΑΚΩΝ ΑΠΟ ΕΠΙΚΑΛΥΜΜΕΝΕΣ ΣΤΕΡΕΕΣ ΦΑΡΜΑΚΟΤΕΧΝΙΚΕΣ ΜΟΡΦΕΣ
… TECHNICAL DIFFICULTIES ENCOUNTERED DURING DIRECT COMPRESSION AND (B) TO CONSTRUCT A NEW AQUEOUS FILM COATING SYSTEM ABLE TO IMPROVE TABLET QUALITY AND TO CONTROL THE RATE OF DRUG RELEASE HAS BEEN DESCRIBED. THE DATA PRESENTED INDICATED THAT (I) BORON ALLOY COATING OF TOOLS (PUCHES AND DIE) …
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Ultrasonic NDT Methods for the Evaluation of Post-Tensioned Systems with Flexible Fillers
… first method, diffuse ultrasound spectroscopy, indirectly evaluates posttensioned structures by quantifying the severity of microcracking in the structure. Microcrack detection is accomplished by processing received waveforms generated with a pitch-catch transducer configuration. The second …
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Comparison of design methods for shear in reinforced concrete beams
… the force transfer from load to reaction by the direct compression struts. For slender reinforced concrete beams, either method is suitable for design.
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The Effect of Crystalline and Amorphous Lactose on Mechanical Properties of Roller Compaction Ribbons and Tablets
… formulation and processing. Lactose grades for direct compression applications for example, contain various concentrations of crystalline and amorphous content. The mixture of forms exhibit unique material compaction properties that facilitate performance within formulations. Lactose is …
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Estudio de prefactibilidad para la instalación de una planta productora de dentífrico en forma de pastillas
… Also, with respect to the production process, direct compression technology will be used to produce the solid toothpaste, in a process known as Tableting. In the chapter about budgets and evaluation of the project, it was estimated that the total investment of the project would amount to S/ 1 …
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Chondrocyte biomechanics and chondrogenesis
… of cartilage afflictions. Mechanical forces directly influence the biological processes of native chondrocytes; understanding and controlling this phenomenon begins at the single cell level. Thus, the first aspect of this thesis analyzes the biomechanical nature of the single chondrocyte by …
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Novel Application of Twin Screw Extruder on Production of Diverse Formulations
… make Kollidon® SR an extraordinary option for direct compression of high hardness and low friability tablet. In addition, the low glass transition temperature (Tg) of about 35 oC should make Kollidon® SR a perfect candidate for twin screw extruder. But this application is rarely reported. This …
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Development of Co-processed Plasticized Cellulose Acetate for Sustained Release Matrix Tablets
… tablets of cellulose acetate can be prepared by direct compression or wet granulation methods. However, previous studies showed that a large amount of CA was required to achieve the desired sustained release profile for a sparingly soluble drug and it was difficult to formulate a highly water …
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Drug release from pellets and matrices based on cellulose ethers.
… Accela-Cota. Matrices were prepared either by direct compression or wet granulation. Compendial dissolution methodology was used to determine drug release from coated pellets as well as matrices. Release exponents indicating release mechanisms were calculated from the dissolution data. The …
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Development of hot-melt extrusion as a novel technique for the formulation of oral solid dosage forms
… and cross-linked polyvinylpyrrolidone while a direct compression process was used to compress the ODTs under various compaction forces to optimize tablet robustness. The properties of the compressed tablets which included porosity, hardness, and friability and dissolution profiles were further …
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Engineering of composite pharmaceuticals with improved physicochemical and mechanical properties
Tabletting by direct compression (DC) is the preferred method of tabletting as compared to granulation techniques because among other benefits it is simple, quick, and cost-effective. However, most pharmaceutical powders are not compressible via DC due to poor flowability, compactibility, …
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Modification of natural hydrophilic polymers for use in pharmaceutical formulations
… of compacts. The good compaction and compression properties exhibited by the chitin–metal silicates were found to be strongly dependent upon the type of metal silicate co-precipitated onto chitin. In addition, the inherent binding and disintegration abilities of chitin–metal silicates …
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Evaluation of the critical parameters and polymeric coat performance in compressed multiparticulate systems
Compression of coated pellets is a practical alternative to capsule filling. The current practice is to add cushioning agents to minimize the stress on the coated pellets. Cushioning agents however add bulkiness and reduce the overall drug loading capacity. In this study, we investigated the …