Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"DIPG"”.
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Comprehensive Analysis of the Molecular Underpinnings of Pediatric Glioma
… prognosis. Diffuse intrinsic pontine glioma (DIPG) is a subtype of pediatric glioma that arises in the pons of children. DIPG prognosis is dismal, with a median survival of 10 months. Previous sequencing efforts identified frequent p.K27M mutations in Histone H3 which resulted in a global loss …
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Comprehensive Integrated Genomic and Histopathological Analysis of Paediatric Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine glioma (DIPG) is a devastating, inoperable paediatric brain neoplasm with no effective therapy and near 100% fatality. Diagnosis is based mainly on radiological findings and numerous clinical trials using adjuvant chemotherapy over the last four decades have not shown a …
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Characterisation of genetic and epigenetic aberrations in paediatric high grade glioma
… including diffuse intrinsic pontine glioma (DIPG) are highly aggressive tumours with no effective cures. Lack of understanding of the molecular biology of these tumours, in part due to lack of well-characterised pre-clinical models, is a great challenge in the development of novel therapies. …
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Establishing Intratumoral Modulation Therapy as a New Treatment Modality for High Grade Gliomas
… GBM and diffuse intrinsic pontine glioma (DIPG) and has demonstrated potent anti-neoplastic, pro-apoptotic effects of IMT in vitro without significant impact on non-cancerous post-mitotic neurons. The co-application of IMT also potentiates the benefits of chemotherapy and gene therapy. We …
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The use of ion pairs to increase the percutaneous delivery of diclofenac
… propylene glycol (PG), and dipropylene glycol (DiPG) were selected for high DNa solubility and water miscibility. A model binary system of TC and water was developed to evaluate novel ion pair formulations. Finally, formulation optimisation investigated solvent substitution effects and developed …
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Elucidating intratumour heterogeneity through investigation of clonal, transcriptomic, and proteomic features across models of triple negative breast cancer and diffuse intrinsic pontine glioma
… first serial two photon tomography volume of a DIPG model, revealing diffuse spread from the hindbrain towards the frontal lobe, and setting the stage for exciting subsequent developments. This thesis builds upon the existing work documenting intratumour heterogeneity in the 4T1 model of triple …
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Focused ultrasound-mediated drug delivery to the brainstem
<p>Brainstem gliomas are tumors that occur in the brainstem, the brain region that connects the brain to the spinal cord and controls vital body functions. The critical anatomic location of the brainstem precludes surgical intervention and limits the use of invasive therapeutic techniques. …