Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"DIO2"”.
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Expression of DIO2 in the Porcine Ovary and the Granulosa Cells of Humans
… them using real-time PCR. We found the gene DIO2 was regulated and chose to conduct further studies. Although, DIO2 is well characterized in the heart and other tissues it has not been characterized in the ovary. The DIO2 enzyme is primarily responsible for converting the less active form the …
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Investigating thyroid hormone transport and regulation in chorionic somatomammotropin RNAi models of intrauterine growth restricted pregnancies
… of placental deiodinase 2 and deiodinase 3 (DIO2/DIO3) mRNA have been implicated in IUGR. It has been reported that nutrient restricted models of IUGR pregnancies result in a decrease of thyroxine levels in maternal and fetal circulation. Transthyretin (TTR) is a TH binding molecule produced …
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Exogenous Mitochondrial Transfer and IL-6: Modulating Adipocyte Metabolism in Obesity-associated Dysregulation
… of energy expenditure genes, notably Ucp1, Dio2, Ppara, and Ppargc1a, upon exposure to exogenous mitochondria, thereby promoting a favorable shift in metabolic profiles within white adipocytes. Mitochondria therapy also appeared to stimulate mitochondrial biogenesis through an increase in …
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The Physiological Function of Endothelin-2 in Mice
… temperatures. Despite the severe hypothermia, DIO2 and UCP-1 failed to increase in brown adipose tissue in ET-2 knockouts. Housing these mice in a warm environment significantly extended the median life span. As temperature regulation is controlled by the central nervous system (CNS), I …
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EFFECTS OF HISTONE DEACETYLASE INHIBITORS ON ENERGY METABOLISM
… , such as PRDM16, CIDEA, UCP1, ELOVL3 and DIO2, and an induction of mitochondrial biogenesis, after MS275 administration. In parallel, adypocyte size appeared smaller respect to the adipocytes of the control group. In white adipose tissue, we observed an increase of adipocytes markers and, …