Global ETD Search
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Showing 1 to 18 of 18 for “"DILI"”.
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Understanding the transport mechanisms of BSEP to improve the prediction of DILI compounds
At present, Drug-Induced Liver Injury (DILI) is the most frequent cause of acute liver injury, with an incidence ranging from 0.023-1.5‰ in developed countries. DILI can be separated into two different types. Whereas intrinsic DILI concerns predictable dose-dependent hepatoxicity, idiosyncratic …
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N-Acetylcysteine for non-paracetamol drug-induced liver injury: A systemic review
… options for drug-induced liver injury (DILI). N-acetylcysteine (NAC ) is known to be of benefit in management of DILI due to paracetamol overdose and may also be useful in the management of non-paracetamol DILI. Our objective was to systematically review evidence for the use of NAC as a …
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A randomised controlled trial of N-acetylcysteine in the management of anti-tuberculosis drug-induced liver injury
… causes, such as ATT-induced liver injury (AT-DILI). Rechallenge of first line ATT after liver injury is usually attempted and may result in recurrence of liver injury. Alanine transaminase (ALT) is the biomarker currently used in AT-DILI diagnosis. MicroRNA-122 (miR-122) is a sensitive …
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Using free-text searching and ICD-10 codes to identify prospective patients with drug-induced liver injury
<p>Drug-induced liver injury (DILI) is a rare cause of liver disease that is difficult to diagnose due to the lack of a confirmatory test. The Drug-Induced Liver Injury Network (DILIN) was developed to enroll patients with DILI to understand the clinical outcomes of the disease. The present study …
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Integrated imaging and circulating biomarkers for the assessment of drug-induced hepatotoxicity
Drug-induced liver injury (DILI) is a major burden for health care systems and a principal reason for attrition during drug development. Prediction of clinical DILI remains difficult and diagnosis is usually based on exclusion using blood-based biomarkers for cell injury. Currently used chemistry …
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Human Liver Organoids as models for investigating drug-induced liver injury
… to the risk of drug induced liver injury (DILI). DILI is the main cause for acute liver failure in western countries and post-marketing withdrawal of drugs. This is highly due to the poor identification of potential human hepatotoxins during the preclinical phase of drug discovery. It is …
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The natural history of Efavirenz Drug Induced liver injury
… reported EFV drug induced liver injury (DILI), is unknown. Objectives To establish causality assessment for the drug-induced liver injury and elucidate the natural history of EFV DILI by observing a cohort of patients through documenting all the factors influencing the patterns of …
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Engineering complex liver models for drug screening and infectious diseases: a biomaterials and co-culture perspective
… in conditions such as drug-induced liver injury (DILI), which is the leading cause of the prelaunch attrition and post-market withdrawal of pharmaceuticals, or diseases such as viral hepatitis. Hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are major health problems that affect >250 …
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Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa
… and or ART-associated drug-induced liver injury (DILI) amongst all patients presenting with significant liver injury to GF Jooste Hospital during the study period. 2. To describe base line clinical characteristics and management of TB treatment and or ART-associated DILI patients. 3. To describe …
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Development of circulating microRNA in drug-induced liver injury: studies in humans and zebrafish
… also investigated. First, the miRNA signature of DILI induced by paracetamol was defined. Plasma miRNAs were quantified in paracetamol overdose patients. A signature of 16 miRNAs was discovered that best separated patients with liver injury from those without liver injury. This signature was …
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Liver Injury in HIV-positive Patients on Antituberculosis and/or Antiretroviral Therapy – Assessing Causality
… in identifying a drug-induced liver injury (DILI) due to antituberculosis therapy (ATT) and/or antiretroviral therapy (ART). Methods Cases were drawn from a prospective registry of hospitalised adults with suspected DILI due to ATT and/or ART in Cape Town, South Africa. Participants had to …
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Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury
… states as well as drug-induced liver injury (DILI). The interactions that mediate susceptibility to liver injury and disease, however, are still poorly understood, underscored by the complexity of immune interactions and the diverse cellular composition and functions of the liver. Using …
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“We Don’t Hear All The Stories”: East Timorese Youth And Education About The Indonesian Occupation
… conducted with twenty East Timorese youth in Dili, Timor-Leste. In addition, informal observations and textbook analysis were undertaken as a way of triangulating the data from interviews. The data from the interviews and focus groups presented and analyzed in this study demonstrate that East …
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Using transcriptomic data to detect, understand, and treat injury in the context of drug toxicity and fibrotic disease
… in an interactive manner, the R/Shiny app “DILI Cascades” is presented in Chapter 4. Instead of drug toxicity, the last chapter then focusses on efficacy and aims to prioritise repurposing candidates, direct targets and downstream effectors which may promote alveolar regeneration in …
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Development of 3D multicellular liver organoids derived from human induced pluripotent stem cells to model antiretroviral therapy induced liver injury
… (HLOs) to model drug induced liver injury (DILI) by exposing HLOs to Antiretroviral therapy drugs (ART), combination of ART and antituberculosis drugs (A+TB) and Schistosoma mansoni egg soluble antigen (SEA) or Troglitazone (TGZ). Methods: A quantitative reverse transcriptase-polymerase …
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Enacting the 3rd Cycle Science Education Curriculum in Timor-Leste
… from three municipalities in Timor-Leste: Dili, Baukau, and Likisa, three Ministry of Education officials, two educationalists, and three student teachers. Data were collected from multiple sources such as focus group discussions, individual interviews, and documentary analysis. Content and …
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O eu e o outro processo de cooperação: Timor como caso e exemplo
… da população mais velha domina esta língua. Em Dili, a capital, não se sentem os efeitos do ensino do português. Como nos referem os habitantes desta cidade “ Portugal precisa de enviar professores que ensinem o português aos mais novos”