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Showing 1 to 9 of 9 for “"DIHYDROPYRIDINES"”.
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Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype
The blood stage of the malarial parasite life-cycle is a vital stage that is believed to be a target for most antimalarial drugs. It is in this stage that host haemoglobin is degraded to provide nutrients for the survival of the parasite. However, a pathway (known as the haem detoxification …
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Diversification of 4-Alkylpyridines: Mining for Reactivity with Alkylidene Dihydropyridines
… pyridines under mild conditions via alkylidene dihydropyridines (ADHPs). Recent work in our group has demonstrated the utility of ADHPs in palladium-catalyzed reactions. However, the fundamental reactivity of ADHPs remains largely unexplored, with only scattered reports in the literature. We …
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Designing new chiral hydroxamic acid ligands for the asymmetric epoxidation reaction in water
… been prepared as precursors to the corresponding dihydropyridines. It was our initial intention to utilise these chiral dihydropyridines in the enantioselective reduction of imines. This would result in the formation of the desired chiral amine and a quaternary pyridinium salt, which could then be …
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Chemistry of the Degradation of Vinyl Polymers to give Carbon Fibre Precursors
… by analogy with the known chemistry of 1,4-dihydropyridines, will oxidise on exposure to air to a fully aromatic condensed pyrinoid system. This theory has been extended to cover the thermal and oxidative degradations of polyacrylonitrile in the solid state, It is concluded that the …
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The Characterization of Nemadipine and Migrazole as Small Molecule Tools for Use in the Nematode Caenorhabditis elegans
… Nemadipine is structurally analogous to 1,4-dihydropyridines (DHPs), which target the Cav1 calcium channel and are used clinically to lower blood pressure. Phenotypic and genetic evidence suggest that nemadipine targets the worm Cav1 channel, EGL-19. To identify the target of nemadipine in an …
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The Roles of Ca2+ and cAMP in the Nematocyst Discharge of the Sea Anemone Tentacle
… L-type calcium channel blockers, including dihydropyridines. The coincidence of the desensitization region of the nematocyst discharge curve with those NANA concentrations that most stimulate calcium influx, suggests a role of NANA-stimulated calcium influx in desensitization.</p>
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
… intensive investigation. The 4-Isoxazolyl-1, 4-Dihydropyridines (IDHP’s) have been shown to exhibit inhibition of MDR1. A novel series of IDHP compounds have been prepared and found to inhibit MDR1. The synthesis, MDR1 assay results, and relevant controls will be discussed. If successful, …
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
… intensive investigation. The 4-Isoxazolyl-1, 4-Dihydropyridines (IDHP’s) have been shown to exhibit inhibition of MDR1. A novel series of IDHP compounds have been prepared and found to inhibit MDR1. The synthesis, MDR1 assay results, and relevant controls will be discussed. If successful, …
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ΜΕΛΕΤΗ ΑΝΤΙΔΡΑΣΕΩΝ ΕΤΕΡΟΚΥΚΛΙΚΩΝ ΑΡΩΜΑΤΙΚΩΝ ΝΙΤΡΩΔΑΜΙΝΩΝ
THE NITROSATION OF 4-METHYLAMINO-1-METHYL-PYRIDINIUM PERCHLORATE IN 0.1-4.0 N PERCHLORIC ACID IS OF FIRST ORDER IN AMINE AND NITROUS ACID AND FOLLOWS THE RATEEXPRESSION: R=K3 [AMINE] [NITROUS ACID] HO. (I) THE RESPECTIVE NITROSAMINE FORMED IS EASILY DENITROSATED UNDER THE EXPERIMENTAL CONDITIONS. …