Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"DICER1"”.
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Role of Phosphorylated Dicer1 In Tumor Progression
<p>DICER1 is a multidomain enzyme discovered and widely recognized for its function in small non-coding microRNA (miRNA) synthesis. In cancer development, DICER1 functions as a haploinsufficient tumor suppressor which regulates miRNAs and Epithelial-to-Mesenchymal Transition (EMT). The Arur …
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FMRP and MOV10 regulate local DICER1 expression and dendrite development
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Phosphorylation Impairs Dicer1 Function to Accelerate Aging and Tumorigenesis In Vivo
<p>Altered DICER1 protein levels are associated with developmental disorders, infertility, macular degenerative blindness, aging, and cancer in humans. Recently, post-translational regulation of Dicer1 via phosphorylation has been described in <em>C. elegans</em>. Oscillation of Dicer1 …
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Determining the Roles that DICER1 and Noncoding RNAs Play in Endometrial Tumorigenesis
… of nucleosome-free DNA in expressing cells. The DICER1 protein, which is necessary for processing small RNAs involved in post-transcriptional silencing, is downregulated in many cancers, including endometrial cancer. I used genomic methods: RNA-Seq and MeDIP/MRE) to characterize the transcriptome …
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Identifying the mechanism critical for proliferation, apoptosis, and cell-cell interaction in the development of mouse adrenals and gonads
… I demonstrated a tissue-specific requirement of Dicer1, the key enzyme for microRNA biosynthesis, among adrenal, testis and ovary. Adrenal cortical cells, Sertoli cells and Leydig cells show different sensitivity to the loss of Dicer1. Although Dicer1 was removed at the same time in these …
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Identification of Familial Wilms Tumor Predisposition Genes Using Whole Genome Sequencing
… as well as germline missense mutations in <em>DICER1 </em>(4% of families) and <em>SPHK2</em>. Functional studies demonstrate that the missense mutation identified in <em>SPHK2 </em>does not have an effect on apoptosis or proliferation, but instead alters SPHK2 subcellular localization and …
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Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors
… the development of T1D development by deleting Dicer1 (an enzyme needed for miRNA maturation) early in thymocyte development. We showed that these NOD.Lck-Cre Dicer KO mice had phenotype alterations including markedly decreased amount of αβ CD4+ and CD8+ T cells in the secondary lymph nodes but …
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A functional role for transfer RNA-derived microRNAs in human B cells
… characteristics of a microRNA, including a DICER1-dependent biogenesis, physical association with Argonaute proteins, and the ability to repress mRNA transcripts in a sequence-specific manner. Specifically, CU1276 represses endogenous expression of RPA1, a gene with critical functions in …
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The Roles of miR-155 and miR-15/16 in Natural Killer Cell Function and Maturation
… the cytoplasm where it is further processed by Dicer1, yielding a mature 18-24 nucleotide miRNA. The mature miRNA is loaded into the RNA induced silencing complex (RISC), a component of which is Argonaute-2 (Ago2), and binds to a semi-complementary segment of the 3' untranslated region (UTR) of …
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Enhancement of Dicer as a personalized anticancer strategy
Normal miRNA production is essential for regulating protein expression and cellular fate. Misregulation of miRNA production is emerging as a key factor in the development of many disease states, including most forms cancer. A global downregulation of miRNA processing is common among cancers and has …