Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"DHPS"”.
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Herbicide Mediated Selection of Sulfonamide Resistant E. coli
… protein of sulfas, dihydropteroate synthase (DHPS). ITC confirmed asulam interacts with DHPS, and in vitro directed evolution experiments showed that prolonged asulam exposure can select for sulfa-insensitive DHPS in E. coli. Since mobile sul genes also encode for sulfa-insensitive DHPS, the …
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Structural and Kinetics Studies of the Enzyme Dihydropteroate Synthase and the Implications for Antibiotic Resistance
… study is to develop small molecule inhibitors of DHPS for the treatment of a variety of infectious diseases. According to the World Health Organization (WHO), infectious diseases kill more than 13 million people worldwide every year making it the second leading cause of death behind cardiovascular …
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Novel Sulfated 4-Hydroxycinnamic Acid Oligomers as Potent Anticoagulants
… prepared oligomers of 4-hydroxycinnamic acids (DHPs) as potential anticoagulants. Oligomers were prepared through peroxidase-catalyzed oxidative coupling of 4-hydroxycinnamic acids. The products resulting from this reaction are called CDs, FDs and SDs. Structurally, these sulfated DHPs are …
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Structure- and Ligand-Based Design of Novel Antimicrobial Agents
… </p> <p>Dihydropteroate synthase (DHPS) catalyzes the addition of <em>p</em>-amino benzoic acid (<em>p</em>ABA) to dihydropterin pyrophosphate (DHPP) to form pteroic acid as a key step in bacterial folate biosynthesis. It is the traditional target of the sulfonamide class of …
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Understanding the Role of Hypusine Biosynthesis in Endocrine-Exocrine Crosstalk
… the rate-limiting enzyme deoxyhypusine synthase (Dhps) to post- translationally modify a critical lysine residue which in turn produces the active form of eIF5A that functions in mRNA translation. When we generated animals with a deletion of Dhps in the pancreatic progenitor cells, there was no …
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The Characterization of Nemadipine and Migrazole as Small Molecule Tools for Use in the Nematode Caenorhabditis elegans
… structurally analogous to 1,4-dihydropyridines (DHPs), which target the Cav1 calcium channel and are used clinically to lower blood pressure. Phenotypic and genetic evidence suggest that nemadipine targets the worm Cav1 channel, EGL-19. To identify the target of nemadipine in an unbiased manner, …
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Study of the Cryptosporidium parvum DHFR-TS in the model system Saccharomyces cerevisiae
… an inhibitor of dihydropteroate synthase (DHPS), another enzyme in the folate pathway. Yeast reliant on the C. parvum DHFR domain alone, however, did not show synergy between the two drugs. In vitro assays on purified enzyme revealed that the DHFR domain alone has a lower affinity than the …
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NOVEL CINNAMIC ACID-BASED DEHYDROPOLYMERS FOR EMPHYSEMA: IN VITRO AND IN VIVO ASSESSMENT OF THEIR ACTIVITIES
… that cinnamic acid-based dehydropolymers (DHPs), originally discovered as novel anti-coagulants, protect against emphysema through their potent triple inhibitory actions against oxidative stress, inflammation and elastase, some of the pathogenic mechanisms associated with this disease. …
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A simulation model of antimalarial drug resistance
… triple) and Res5 (presence of DHFR triple and DHPS double) infections changed over the 11 year period with Res3 infections initially increasing and then decreasing while Res5 infections started low and increased to overtake Res3 infections. The timing of the change in this composition of …