Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"DHHC"”.
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Enzymology of DHHC-mediated Protein S-Acylation
… A family of integral membrane enzymes called DHHC proteins because of a conserved Asp-His-His-Cys motif, catalyze protein <italic>S</italic>-acylation within cells. DHHC proteins have been associated with human diseases including cancers, Huntington's disease, and mental retardation. However …
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DHHC PROTEIN ACYLTRANSFERASES CATALYZES THE LYSINE PALMITOYLATION OF MEMBERS OF THE RAS SUPERFAMILY OF SMALL GTPASES
… fatty acylation. Multiple family members of the DHHC class of S- palmitoyl transferases were identified as lysine fatty acyl transferases. Utilizing alkynyl-fatty acid labeling with in-gel fluorescence, we observed members DHHC2/3/7/15 of the DHHC family of S-palmitoyl transferase labeling the …
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Characterisation of the cell-surface localised palmitoyl acyl transferase, DHHC5
… in several physiological and disease pathways. DHHC palmitoyl acyl transferase (DHHC-PAT) enzymes are responsible for catalysing the addition of acyl groups onto cysteine residues and there are 23 human DHHC-PAT isoforms. All isoforms share a conserved DHHC catalytic motif and they display …
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Investigating the mechanisms and outcomes of Sprouty-2 S-acylation
… This PTM is mediated by twenty-three zinc finger DHHC (zDHHC) enzymes that display distinct activity and substrate selectivity profiles. Sprouty (SPRY) proteins are regulators of Receptor Tyrosine Kinase (RTK) signalling and play a major role in maintaining cellular homeostasis. Indeed, their …
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Dhhc5 Regulates Beta-Adrenergic Signaling In The Heart Through Palmitoylation of G Alpha Proteins
… membrane-localized palmitoyl acyltransferase DHHC5 as an important mediator of the stimulus-dependent palmitoylation in cardiomyocytes. Knockdown of DHHC5 showed that this enzyme is necessary for palmitoylation of Gαs, Gαi, and functional responses downstream of β-adrenergic stimulation. A …
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S-Acylation Is A Key Regulator of Orai1/Stim1-Mediated Store-Operated Calcium Entry In T Cells
<p>Orai1 and STIM1 proteins are the essential components of the Ca<sup>2+</sup> release activated Ca<sup>2+</sup> (CRAC) channel which is required for store-operated Ca<sup>2+</sup> entry (SOCE) in T cells and subsequent signaling events leading to T cell activation, proliferation, and …