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Showing 1 to 20 of 37 for “"DHEA"”.
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DHEA-Substitutionstherapie bei gesunden älteren Männern mit niedrigem DHEAS-Serumspiegel
Dehydroepiandrosteron (DHEA) und sein Sulfatester Dehydroepiandrosteronsulfat (DHEAS) gehören zur Gruppe der adrenalen Androgene und sind wichtige Vorläufersubstanzen der Androgen- und Östrogensynthese beim Menschen. Die adrenale Androgensynthese beim Menschen weist einen Rückgang mit zunehmendem …
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Ein Radioimmunoassay (RIA) für die Messung von Dehydroepiandrosteron (DHEA) im Speichel
… handelsüblichen Testkits für die Messung von DHEA im Serum stellen wir einen Radioimmunoassay für die Messung im Speichel vor. Der Testkit wurde in seiner Stabilität, Prezision und einfacher Handhabung validiert. Die Korrelation zwischen Serum und Speichel war hoch. Junge Probanden zeigten …
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LC-ESI-MS/MS quantification of hair cortisol, cortisone and DHEA in combined oral contraceptive users
… was quantified as well. Dehydroepiandrosterone (DHEA), a hormone that has anti-cortisol activity, was also intended to be added to reflect total cortisol exposure. An in-house LC-ESI-MS/MS method was developed to simultaneously quantify cortisol, cortisone, and DHEA in hair. The use of ammonium …
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Dehydroepiandrosterone and dehydroepiandrosterone sulphotransferase activity and expression in human disease
The adrenal steroid dehydroepiandrosterone (DHEA) and its sulphate ester, DHEAS are the most abundant circulating steroid hormones in humans. Uncongugated DHEA predominately exerts its effects via its downstream conversion to active sex steroids in peripheral target tissues. In contrast the …
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Patients with severe cutaneous adverse drug reactions have extremely high hair cortisol concentrations that do not correlate with presence of depression.
… Hair cortisol concentrations (HCC) +/- DHEA, a depression and stress biomarker has not been studied in severe cutaneous adverse drug reactions (SCAR). Objective: To determine DHEA/HCC correlation with SCAR-associated depression and compare the ratio with published values. Methods: …
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Patients with severe cutaneous adverse drug reactions have extremely high hair cortisol concentrations that do not correlate with presence of depression.
… Hair cortisol concentrations (HCC) +/- DHEA, a depression and stress biomarker has not been studied in severe cutaneous adverse drug reactions (SCAR). Objective: To determine DHEA/HCC correlation with SCAR-associated depression and compare the ratio with published values. Methods: …
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Patterns of cortisol and DHEA secretion and relationships with attachment style and psychosocial variables in female adolescents: a developmental psychopathology approach
… samples for the measurement of cortisol and DHEA were collected using the best-recommended methodology: multiple samples over the day, strict reference to time of awakening, and two consecutive sampling weekdays. The research was adolescent-orientated: specifically, by using creative and age …
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Assay procedures for dehydroepiandrosterone
<p>Dehydroepiandrosterone (DHEA) is a 17-ketosteroid which is produced by the adrenal cortex and is excreted in the urine as DHEAsulfate, In diseases of the adrenal cortex, such as adrenal carcinoma or adrenal hyperactivity, the level of DHEA-sulfate in the urine is increased. There are two …
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HPA Axis Dysfunction In Treatment Resistant Affective Disorders
… (TRBD). In addition, dehydroepiandrosterone (DHEA), the other main adrenal steroid, and which may counteract the effects of cortisol on the brain, has never been measured in TRUD or TRBD. Aims and Methods: To assess the state and relevance of HP A axis changes in treatment-resistant depression …
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Regulation of Adrenal Steroidogenesis by Interleukin-6
Cortisol and dehydroepiandrosterone (DHEA) are steroids produced by the zona fasciculata (ZF) and reticularis (ZR), respectively, of the adrenal cortex. Both steroids are upregulated in response to adrenocorticotropic hormone (ACTH). Cortisol is a glucorticoid that is important in the regulation of …
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Επίπεδα ανδρογόνων σε έφηβες: συσχέτιση με τα στάδια σεξουαλικής ανάπτυξης κατά Tanner
… των επιπέδων ανδρογόνων (τεστοστερόνη, SHBG, DHEA-S, DHEA, Δ4-ανδροστενδιόνη, 17-OH προγεστερόνη) με τα στάδια Tanner (μαστού, εφηβαίου και μασχάλης) σε έφηβα κορίτσια και (2) να εξεταστεί κατά πόσο οι αυξημένες τιμές ανδρογόνων σχετίζονται με την παρουσία κλινικών εκδηλώσεων …
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Pharmakokinetik und Biokonversion von Dehydroepiandrosteron nach Dexamethason-Vorbehandlung bei Frauen mit dem Syndrom der polyzystischen Ovarien
… wir eine orale Gabe von Dehydroepiandrosteron (DHEA), dem obligaten Präkursor jeglicher Sexualsteroid-Biosynthese beim Menschen. Unter Suppression der endogenen Steroide analysierten wir die periphere Biokonversion von DHEA zu den Androgenen. An der prospektiven Studie nahmen acht Frauen mit …
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Die Wirkung estrogen aktiver Umweltchemikalien auf Fische : Untersuchung reproduktionsrelevanter Parameter bei Regenbogenforelle und Zebrabärbling
… Octylphenol (OP) und Dehydroepiandrosteron (DHEA) auf Fische nachweisbar. Die Untersuchung ausgewählter entwicklungs-biologischer, reproduktionsbiologischer, anatomischer, histologischer und ultrastruktureller Parameter ermöglichte eine Bewertung schadstoffbedingter Veränderungen während der …
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Rapid social regulation of 3β-HSD activity in the songbird brain
… levels of the prohormone dehydroepiandrosterone (DHEA) are elevated year-round in the plasma and brain. The local conversion of brain DHEA to potent androgens may be critical in regulating non-breeding aggression. 3β-hydroxysteroid dehydrogenase/Δ4-Δ5 isomerase (3β-HSD) catalyzes DHEA conversion …
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Regulation of Estradiol-17beta Synthesis by Small Follicles of the Domestic Hen Ovary
… to increasing concentrations of P$\sb5,$ DHEA, and P$\sb4.$ DHEA was preferred by small follicles for steroid production, suggesting that the $\Delta\sp5$ pathway may be dominant in small follicles. Steroidogenic pathways use by tissues was investigated by thin layer chromatography. …
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Salivary VIP concentrations are elevated in humans after acute stress
… indicators cortisol, dehydroepiandrosterone (DHEA) (Morgan et al., 2004) and amylase (Nater et al., 2006) of the stress response. Depending on the stressful situation or stress paradigm, we used an indicator or biomarker profile in conjunction with the use of psychological assessments in order …
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Effect of extra-gonadal sperm depletion on steroid hormone profiles in semen of bulls
… androstenedione (A), dehydroepiandrosterone (DHEA), and progesterone (P) in bovine semen were established for a group of four post-pubertal bulls by depleting the bulls' extra-gonadal sperm reserves (EGR) on three occasions at two week intervals. Each depletion consisted of 14 consecutive …
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Tracing Androgen Metabolism With Inhibition Of Aromatase In Breast Cancer: In Vitro Studies And Clinical Correlates
… steroid precursor dehydroepiandrosterone (DHEA) and its sulfate conjugate was assessed in in vitro models of ER+ breast cancer (MCF-7 variant cell lines +/- aromatase). These studies demonstrated estrogen formation from physiological levels of DHEA and DHEA-S in MCF-7 variants after growth …
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