Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"DFO"”.
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Effects of DFO-Induced Hypoxia on Key Signaling Mediators
… examined using human neuronal cells treated with DFO to create a hypoxic-mimic condition. We found that MOR expression was shown to decrease over increased exposure times to DFO. Recently, our laboratory reported that receptor associated C kinase (RACK-1), interacting with the transcription …
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Prevention of bacterial growth in platelet products via inclusion of iron chelators
… treatment with the iron chelators deferoxamine (DFO) or phytic acid. DFO significantly inhibited bacterial growth in a dose dependent manner (p < 0.009). Conversely, phytate only inhibited bacterial growth at concentrations ≥ 100 mM (p < 0.001); at ≤ 5 mM, phytate supplied S. epidermidis with …
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Evaluation of the Commercial Groundfish Integration Pilot Program in British Columbia
… the Minister of Fisheries and Oceans Canada (DFO) accepted an industry proposal called the Commercial Groundfish Integration Pilot Program (CGIPP), which integrated each of the seven commercial groundfish fisheries in British Columbia. The industry proposal, developed by the Commercial …
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Chemical Induced Hypoxia Differentially Affects Gene Expression in Human Neuronal Cells
<p>Previously, our laboratory used desferoxamine (DFO), to generate hypoxic conditions (a low oxygen condition) which decreased human neuronal cell viability, but some cells still survived. These surviving neurons showed no morphological changes when compared to the non-treated group. However, the …
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Derivative-Free Methods for High-Dimensional Optimization with Application to Centrifugal Pump Design
… For such problems, derivative-free optimization (DFO) methods offer a means of optimizing using only function evaluations. Unfortunately, many of these methods suffer from the curse of dimensionality — that is, as the problem dimension increases, these methods become less effective. In order to …
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How sustainable are elasmobranch catches in Canadian pacific commercial fisheries?
… caught in fisheries targeting teleosts (DFO, 2007). Here I estimate the interception of elasmobranchs within Canadian Pacific commercial fisheries over the last 30 years (1980-2013) through a critical review of fisheries management and analysis of DFO catch statistics. A total of 208,642 …
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Leveraging Antibodies for Positron Emission Tomography and Near-Infrared Fluorescence Imaging of Cancer
… tomography (PET) imaging agent, <sup>89</sup>Zr-DFO-pertuzumab, in mouse models of human breast cancer. In the second part, we developed two imaging agents for ovarian cancer, <sup>89</sup>Zr-DFO-AR20.5 for PET and <sup>ss</sup>B43.13-IR800 for near-infrared fluorescence imaging and evaluated …
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Action shift : cyclically reflexive constructivist grounded action research informs pragmatic collaborative natural resource management strategies and tools for consideration by Fisheries and Oceans Canada, pacific region
… management for Fisheries and Oceans Canada's (DFO) consideration. The study developed grounded theory, which reflexively informed collaborative strategies and supported action-oriented collaborative tool development. Outcomes were developed to address each of three research questions through …
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Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease
… or combined with the iron chelator deferoxamine (DFO), to protect against rotenone‐induced parkinsonism in SH‐SY5Y cells, and in a co‐cultured hCMEC/D3 ‐ SH‐SY5Y cellular BBB model. In Parkinson’s disease (PD), excess free iron drives the accumulation of toxic hydroxyl radicals within mitochondria …
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The Development of Novel Radioimmunoconjugates for the PET Imaging and Radioimmunotherapy of Cancer
… to prepare [<sup>89</sup>Zr]Zr-<sup>SSK</sup>DFO-pertuzumab for visualizing HER2+ breast cancer. Further, we introduce a new mAb with a catalytic domain that allows for the site-selective bioconjugation of chelators to yield [<sup>177</sup>Lu]Lu-CHX-A”-DTPA-PODS-HER2DVD for targeting HER2+ …
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Regulation of mTORC1 Signalling and Amino Acid Uptake by Iron Availability in Caco-2 Intestinal Epithelial Cells
… whole.<br/><br/>The iron chelator deferoxamine (DFO) was used to induce iron deficiency in Caco-2 cells (a cell line derived from a human colorectal carcinoma which has functional properties typical of absorptive enterocytes of the small intestine) in order to assess the effects of iron depletion …
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Development and Characterization of B7-H3-Targeted Radioimmunotherapies For The Treatment of Solid Tumors
… labeled with <sup>89</sup>Zr (<sup>89</sup>Zr-DFO-MIL33B) for PET/CT imaging demonstrated high retention in multiple syngeneic tumor models transfected with human B7-H3 compared to vector controls or tumors imaged with isotype control antibody (<sup>89</sup>Zr-DFO-IgG2a) and in immunodeficient …
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Not just something you put in a frying pan and give to your family : children's meaning making and salmon restoration
… and the Department of Fisheries and Oceans (DFO). The study used a qualitative multimodal phenomenological approach that is theoretically framed through deep ecology and systems theory to answer: What meanings and impacts do children experience when participating in restoration projects? Data …
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Patterns in an elastic bar
… the model and the Derivative Free Optimization (DFO) to find the location of the jump.
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Synthesis, characterisation and application of novel quinones for the detection of latent fingermarks
… zinc (IND‐Zn), 1,8‐diazafluoren‐9‐one (DFO), and ninhydrin. While these techniques produce excellent results, each has their drawbacks. For example, ninhydrin requires secondary post-treatment and cooling with liquid nitrogen to produce fluorescent fingermarks. DFO developed fingermarks …
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Zum Komplexbildungsverhalten ausgewählter Actiniden (U, Np, Cm) mit mikrobiellen Bioliganden
… das natürliche Trihydroxamat Desferrioxamin B (DFO) zum Einsatz und für die Katecholgruppe das 6-Hydroxychinolin (6HQ) und 2,3-Dihydroxynaphthalin (NAP). Als Vergleichsligand wurde außerdem Benzoesäure (BA) untersucht. Für die Bestimmung der Stabilitätskonstanten zur Einschätzung der Stärke der …
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Development and Evaluation of Novel Anti-HER2 Theranostics Against HER2-Positive Breast Cancer
… Conjugation using bifunctional chelators p-SCN-DFO and p-SCN-DOTA afforded DFO-trastuzumab-PEG6-DM1 and DOTA-pertuzumab-PEG6-DM1, respectively for radiolabeling with 89Zr and 67Cu for microPET/SPECT/CT imaging. We also radiolabeled these ADCs with [225Ac]Ac via a stable eighteen-membered …
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HIV-1 gp120 and Methamphetamine-mediated Induction of Proinflammatory Cytokines/chemokines and Oxidative Stress in Astrocytes: Implications in Neuroinflammation
… (DPI), and FWH reaction, deferoxamine (DFO), which significantly reduced ROS production. These findings were further confirmed using specific siRNAs against NOX2 and NOX4 (NADPH oxidase family). Furthermore, gp120 and MA both induced apoptosis (as evidenced by increased caspase-3 …
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A novel and rational approach towards designing aluminium chelators
… Disease. To date, only desferrioxamine (DFO), a trihydroxamic acid siderophore has been used in the clinical environment for the removal of Al from the body. However, this drug is expensive, orally inactive and is associated with many side effects. These studies employed a theoretical …
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