Global ETD Search
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Showing 1 to 2 of 2 for “"DFG-motif"”.
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Biochemical Context Drives Inhibitor Selectivity in Aurora A Kinase
… with all inhibitors promoting either the active DFG-in state or inactive DFG-out states, but to widely differing extents. For example, DFG-out inhibitors preferentially bind the more-dynamic form of Aurora A that is activated by phosphorylation, but DFG-in inhibitors preferentially bind to Aurora …
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Characterization of Parkinson's Disease-associated LRRK2 Kinase
… G2019, located within the magnesium binding DFG motif in the kinase domain, with a serine residue enhances protein kinase activity between 2 to 4 folds. Recently our lab in collaboration with Matthias Mann’s lab discovered that LRRK2 phosphorylates a subset of Rab GTPases including Rab8A and …