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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 98 for “"DEX"”.

  1. The nidogen-domain protein DEX-1 is necessary for the Caenorhabditis elegans dauer morphology and behavior

    Flatt, Kristen M.University of Illinois at Urbana-Champaign2020

    … that the nidogen domain-containing protein DEX-1 facilitates the stage-specific tissue remodeling observed during dauer morphogenesis. DEX-1 was previously shown to function as a secreted extracellular matrix protein that regulates sensory dendrite formation during embryogenesis. However, we …

    uiuc Repository record

  2. Poly(L-lysine)-g-dextran (PLL-g-dex): brush-forming, biomimetic carbohydrate chains that inhibit fouling and promote lubricity

    Perrino, ChiaraETH2009

    ethz Repository record

  3. Dexamethasone- and age-sensitive genes in neonatal small intestine

    Cerqueira, Carla

    … work indicated that priming the gut with Dexamethasone (Dex, a glucocorticoid analog) allowed fructose to precociously stimulate GLUT5 even in suckling pups < 14 d old. This suggests that the effect of Dex on GLUT5 is similar to the effect of age; both allow fructose to stimulate GLUT5. It …

    njit Repository record

  4. Understanding the Differential Effects of Dexamethasone on the Metabolism of Healthy and Diseased Articular Cartilage

    Black, Rebecca M.Massachusetts Institute of Technology2022

    The glucocorticoid drug Dexamethasone (Dex) has been proposed as a potential therapeutic to treat or prevent post-traumatic osteoarthritis (PTOA), a disease affecting millions of Americans without a disease-modifying drug. However, current reports on Dex efficacy often disagree on the effects of …

    mit Repository record

  5. 조골세포 사멸 및 분화에서 GSK3b의 역할

    윤, 선일2011

    … been clearly determined. This study showed that dexamethasone (Dex) induced apoptosis of MC3T3-E1 osteoblasts through the GC receptor. Dex activated GSK3β, and inhibition of GSK3β by lithium, a pharmacological antagonist, or gene knock-down by siRNA prevented the Dex-induced apoptosis. …

    ajou Repository record

  6. Part I: Effect of Nanomicelle Size on Trans-scleral Permeability of Dexamethasone and Part II: Strategies to Minimize Octreotide Acylation during Sustained Release from Biodegradable Polymers

    Vaishya, Ravi D.University of Missouri--Kansas City2015

    … to determine the effect of nanomicelle size on dexamethasone (DEX) transport across the sclera. Nanomicelles of various sizes were developed and characterized. Low molecular weight diblock co-polymers, mPEG₇₅₀-PCL₇₀₀ (DB1), mPEG₂₀₀₀-PCL₁₅₀₀ (DB2) and mPEG₅₀₀₀-PCL₄₀₀₀ (DB3) were synthesized by …

    umkc Repository record

  7. Mechanical and Biologic Impact of Dynamic Loading on Bovine and Human Models of Osteoarthritis

    Szapary, Hannah JacquelineMassachusetts Institute of Technology2022

    Both dexamethasone (Dex) and Insulin-like growth factor 1 (IGF-1) have shown promise as disease-modifying therapeutics for osteoarthritis (OA), a disease characterized by cartilage degradation. Additionally, dynamic loading has been demonstrated to affect chondrocyte metabolic activity, with …

    mit Repository record

  8. Perioperative Education on the Utilization of Dexmedetomidine for Surgical Patients

    Mena, Raiza StephanieThe University of Arizona.2024

    … practitioners’knowledge of the application of dexmedetomidine (DEX), focusing on maximizing patient care during general anesthesia or procedural sedation. Background. The analgesic, sedative, and anxiolytic qualities of DEX, a selective alpha-2 adrenergic agonist, provide exceptional benefits …

    arizona-thes Repository record

  9. Cost utility and budget impact analysis of bortezomib and lenalidomide for the treatment of relapsed/refractory multiple myeloma in the South African public health sector

    Matsela, Lineo MarieUnknown2021

    … clinical efficacy are lenalidomide plus low-dose dexamethasone (LEN/DEX) and bortezomib monotherapy (BORT). The clinical effectiveness of both regimens for second-line treatment of RRMM was reported in the MM009/010 and the APEX studies, respectively, where each regimen was compared against …

    cape-town Repository record

  10. Uso de dexmedetomidina como tratamiento coadyuvante de síndrome de abstinencia alcohólica: revisión sistemática

    Tolosa Rodríguez, Miguel AntonioUniversidad del Rosario2016

    El objetivo de este estudio es establecer si la dexmedetomidina (DEX) es segura y efectiva para el manejo coadyuvante de síndrome de abstinencia a alcohol (SAA) a través de la búsqueda de evidencia científica. Metodología: se realiza una revisión sistemática de literatura publicada y no publicada …

    rosario Repository record

  11. Comparative efficacy of three common treatments for equine recurrent airway obstruction

    Lee, Laura CarynVirginia Tech2009

    … three treatment regimens: tapering doses of dexamethasone (DEX), environmental modification (ENV), and a combination of both treatments (DEX + ENV) by analyzing clinical parameters, pulmonary function testing, bronchoalveolar lavage fluid (BALF) cytology and BALF cell expression of the …

    vt Repository record

  12. Mechanisms of glucocorticoid pro-inflammatory effects on CCL20: crosstalk and synergy

    Nhundu, TawandaDepartment of Molecular and Cell Biology2018

    … The present study investigated whether the GC dexamethasone (dex) and the pro-inflammatory inducer TNFα could induce CCL20 expression in a variety of human epithelial cell lines, and a simian fibroblast cell line. Using Real-Time Quantitative Reverse Transcription PCR (qRT-PCR), it was …

    cape-town Repository record

  13. Optimizing chondrogenic factors and protein delivery methods for cartilage repair

    Florine, Emily MarieMassachusetts Institute of Technology2012

    … production by investigating the effects of Dexamethasone (Dex) and HB-IGF- I (heparin-binding insulin-like growth factor-1) on cells encapsulated in the self-assembling peptide RAD and agarose hydrogels. Dex is a synthetic corticosteroid that has been shown to improve cartilage-like tissue …

    mit Repository record

  14. Aerobic Exercise-Mediated Prevention Against Glucocorticoid Myopathy in Aged Skeletal Muscle

    2024

    … to either daily treatment with injections of dexamethasone (DEX) or saline. Following treatments, the contractile properties of the triceps surae complex were assessed in situ. DEX marginally lowered muscle mass and soluble protein content in both sexes, which was attenuated by aerobic …

    fsu-retro

  15. Programming of cardiovascular disease: an exploration of epigenetic mechanisms

    Rose, Catherine MargaretThe University of Edinburgh2015

    … administration of the synthetic glucocorticoid dexamethasone (Dex) to pregnant rats during the last week of gestation. These ‘programmed effects’ can be transmitted to a second generation through both maternal and paternal lines. The overall hypothesis for this thesis was that the transmission …

    edinburgh Repository record

  16. Total intravenous anaesthesia in dogs: development of a target controlled infusion (TCI) scheme for propofol

    Beths, ThierryUniversity of Glasgow2008

    … medetomidine (MED) and its active enantiomer dexmedetomidine (DEX). The study was divided into 4 phases. In phase one, canine PPF pharmacokinetic (PK) parameters, derived from previous studies reported in the literature, were incorporated to a Target Controlled Infusion (TCI) system. This …

    glasgow Repository record

  17. In vitro model of injury/cytokine-induced cartilage catabolism modulated by dynamic compression, growth factors, and glucocorticoids

    Li, Yang, Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2013

    … growth factor-1 (IGF-1) and the glucocorticoid dexamethasone (Dex) was tested as a potential therapeutic for PTOA. The effects of this combination were examined at the transcriptional and protein levels in the presence of IL-i a. Our results showed that the combination of IGF- 1 and Dex …

    mit Repository record

  18. Investigating the effect of dexamethasone on productivity, immune function, and behavior in dystocic periparturient dairy cattle

    Bryant, Dana MarieVirginia Tech2022

    … period, we administered either a potent steroid, dexamethasone (DEX), or a saline control (CON) to cows within 12 hours after a dystocic parturition. The inflammatory marker haptoglobin was measured as well as behavioral and production measures. We observed that primiparous DEX cows exhibited a …

    vt Repository record

  19. Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo

    Garrud, Tessa Aimee CatrionaUniversity of Cambridge2020

    … are not optimised including; drug choice (Dexamethasone, Dex, or Betamethasone, Beta), and drug formulation. There is increasing animal and human data that suggest exposure to high doses of synthetic glucocorticoids may have a detrimental effect on the fetal cardiovascular system. The …

    cambridge Repository record

  20. The Fruit of Poncirius Trifoliata Promotes Mesenchymal Stem Cell Differentiation into Osteoblasts in Glucocorticoid-induced Osteoporosis Model

    윤, 형영2011

    … expression and mineral nodule formation in dexamethasone (DEX)-treated MC3T3-E1 cells and primary bone marrow mesenchymal stem cells (BMSCs). Five fractions of ethyl acetate extract of poncirus trifoliata through column chromatography over a silica gel eluting in gradient system and combined …

    ajou Repository record

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