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Showing 1 to 12 of 12 for “"DESI-MS"”.
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Investigation of Phospholipids in Ethanol Affected Prenatal Mouse Brain Using DESI-MS Imaging
… in various regions of the brain using DESI-MS imaging. FASD mouse models were used in this study in which alcohol was administered to the pregnant mice during first trimester and 30 day old offsprings were chosen for the analysis. Principal component analysis was performed on six …
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Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)
… electrospray ionization mass spectrometry (DESI-MS), a new ambient ionization method with focus on the direct analysis of liquid samples. A variety of new applications of liquid sample DESI are discussed in details including protein conformation study, fast reaction kinetics study, and the …
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Ambient ionization - mass spectrometry: Advances toward intrasurgical cancer detection
… of ambient ionization – mass spectrometry (MS) for clinical measurements, specifically intrasurgical cancer detection. The molecular differences between normal and cancerous tissue were detected via direct tissue analysis in vitro by touch spray ionization (TS) or by analyzing sectioned or …
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Mass Spectrometric Analysis of Thiol Proteins/Peptides Following Selenamide Derivatization And Electrolytic Reduction of Disulfide Bonds
<p>Ambient mass spectrometry (MS) methods such as desorption electrospray ionization-mass spectrometry (DESI-MS) provides direct ionization of analytes with little or no sample preparation. The capability for liquidsamples analysis allows DESI-MS to be coupled with many devices such as …
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Molecular diagnosis of cancer using ambient ionization mass spectrometry
… electrospray ionization mass spectrometry (DESI-MS) imaging, which has been previously used to analyze and differentiate disease state (i.e. tumor and normal) and in some cases tumor subtype of human liver, kidney, bladder, testicular, prostate, and brain cancers. DESI-MS imaging is an ideal …
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Evaluation of Ion Transfer Capillary Geometry on Sensitivity of a Desorption Electrospray Ionization and Mass Spectrometry System
… Electrospray Ionization – Mass Spectrometry (DESI-MS) process. Previous work has shown that heating the ion transfer capillary to 450˚C will improve the resolution of images taken by the DESI-MS owing to increased ion desolvation. This thesis studies how changing the inner diameter and …
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Characterization, Imaging and Quantitation of Small Molecules by Ambient Ionization Mass Spectrometry
… of interest, ionization techniques such as DESI, PS, MALDI, etc are incorporated into the front of the mass spectrometer. In this work, the ambient ionization techniques, DESI-MS and PS-MS was modulated for characterization, imaging and quantification of small molecules. The use of DESI-MS …
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Molecular Determinants of Residual Disease In Ovarian Cancer
… and FABP4 in ovarian cancer. Using RPPA and DESI-MS imaging techniques, we explore the downstream pathways of FABP4 and discovered that FABP4 regulates several pathways associated with metastasis as well as it affects several metabolites in ovarian cancer cells. Collectively, our study …
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Marine natural products as antimicrobial chemical defenses and sources of potential drugs
Marine organisms are widely recognized sources of an impressive array of structurally unusual compounds. Marine natural products have exhibited interesting biomedical activities, provided targets for synthetic organic chemists, and afforded opportunities for elucidation of enzymatic mechanisms …
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Characterization and control of lithium-ion battery interfaces
… and chemical stability to the battery and forms on the surface of the electrodes upon initial battery cycling. Chapter 4 will show an operando approach using vibrational sum-frequency (SFG) spectroscopy (a surface sensitive technique) to observe the real time growth of one of the main …
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Μικροβίωμα στο ενδομήτριο
… Προηγμένα διαγνωστικά εργαλεία, όπως το DESI-MS, αναδύονται για την ταχεία αξιολόγηση των αλληλεπιδράσεων μικροβιώματος-ξενιστή, προσφέροντας νέες οδούς για διαστρωμάτωση κινδύνου και εξατομικευμένες παρεμβάσεις. Η κυριαρχία των Lactobacillus στο γυναικείο αναπαραγωγικό σύστημα, ειδικά …
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Application of ambient mass spectrometry in electrochemical systems
… on 2017-09-29T16:39:22Z (GMT). No. of bitstreams: 3 LIU-DISSERTATION-2017.pdf: 20432445 bytes, checksum: 822e7960639d048f27c3a1682c181f9d (MD5) LICENSE.txt: 4208 bytes, checksum: 26bcd64ff74cb25876083ac4ab0eacd2 (MD5) PROQUEST_LICENSE.txt: 4554 bytes, checksum: c15d3e883db05cb08945e0982de3350c …