Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"DENV"”.
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Discovery and characterization of a newly emerged DENV serotype.
Dengue virus (DENV) is a mosquito-transmitted flavivirus that presents a substantial threat to public health worldwide. One third of the global population is at risk of infection and over 400 million cases of dengue are reported per year. DENV is maintained in two transmission cycles: a sylvatic …
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Studies Toward the Synthesis of Salvinorin A and Synthesis of Broad-Spectrum DENV/WNV NS3 Protease Inhibitors
… Part II: West-Nile Virus (WNV) and Dengue Virus (DENV), both members of the Flavivirirus genus, are transmitted to humans by mosquito vectors and are significant causes of human illness worldwide. The majority of people infected with either virus remain asymptomatic, however some of those infected …
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Characterization of a recombinant chimeric yellow fever 17D vaccine - dengue-4 virus
… virus termed dengue virus-1 to dengue virus-4 (DENV-1 to DENV-4) There are currently no licensed therapeutics, but there is a recently licensed recombinant live attenuated tetravalent vaccine, termed Dengvaxia™ by Sanofi Pasteur, available in some countries. This vaccine was based on Chimerivax™ …
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Isolation and characterization of dengue virus membrane-associated replication complexes from Aedes aegypti
… that a balance exists between dengue virus (DENV) replication in Aedes aegypti and the mosquito's RNA interference (RNAi) based antiviral response. Here, we have isolated and characterized membrane-bound replication compartments from mosquito cell culture and Ae. aegypti to evaluate the role …
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In Vitro and In Vivo Effects of Espirito Santo Virus on Dengue Virus Replication
… centuries (Morens et al., 2004). Dengue virus (DENV), Zika (ZIKV), Chikungunya (CHIKV) and West Nile virus (WNV) are some of the medically important arboviruses transmitted by mosquitoes. Dengue is one of the most common arthropod diseases with over 400 million people infected yearly. Dengue is …
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Characterization of the antiviral activity of cyclosporine A against dengue virus
Dengue virus (DENV) currently threatens 3.9 billion people, a number expected to rise to 6.1 billion by 2080, yet no specific antiviral treatments are available despite 80 years of research. Cyclosporine A (CsA), an immunosuppressive drug, has emerged as a potential broad-spectrum antiviral …
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Sylvatic dengue: evolution, emergence, and impact on human health
Dengue viruses (DENV) are the most important arboviral pathogens in tropical and subtropical regions throughout the world. Transmission includes a sylvatic, enzootic cycle between nonhuman primates and arboreal mosquitoes of the genus Aedes, and an urban, endemic/epidemic cycle between Aedes …
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A Structural Perspective of Antibody Neutralization of Dengue Virus
<p>The four dengue viruses: DENV) are mosquito-borne flaviviruses and are considered the world's most significant arboviruses in terms of worldwide disease burden. Symptoms of dengue disease are classified into dengue fever, a mild, febrile illness, and the potentially fatal severe dengue, which …
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Structure-function of Dengue 2 virus envelope protein domain III with neutralizing antibodies
… protection from disease caused by the DENVs and the envelope (E) protein is the primary target. Potency of neutralization has been correlated with the particular domain on the E protein recognized by a neutralizing antibody, with domain III of the E protein (ED3) being the target of the …
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Studies on the antibody repertoire in a Dengue virus immune subject and isolation of neutralizing antibodies by phage display technology
Dengue Virus (DENV) is known as the causative agent of Dengue Fever and Dengue Hemorrhagic Fever / Dengue Shock Syndrome (DHF/ DSS). Infection with one of the serotypes elicits long-term, homotypic protection but does not protect from the risk of development of DHF/DSS upon subsequent infection …
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Ribosomal Proteins RPLP1 and RPLP2 are Host Factors Critically Required for Flavivirus Infectivity by Promoting Efficient Viral Translation Elongation.
… global health threats, including dengue virus (DENV). We identified two ribosomal proteins, RPLP1 and RPLP2 (RPLP1/2), that are crucial host factors required for translation of flaviviruses and efficient flavivirus infection of human cell lines and Aedes aegypti mosquitoes, which are natural …
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Characterizing Zika and West Nile virus infection in mast cells and the antibody-dependent enhancement potential mediated by dengue virus antibodies
… Within the Flavivirus genus, dengue virus (DENV), Zika virus (ZIKV), and West Nile virus (WNV) are evolutionarily related mosquito-borne viruses with antigenic similarities. The antigenic similarities present between 4 circulating DENV serotypes create an immunological paradox called …
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Thioaptamers Targeting Dengue Virus Type-2 Envelope Protein Domain III
The Dengue Virus Type-2 (DENV-2) is an arbovirus that belongs to the family of Flaviviridae, genus Flavivirus. It includes Dengue virus (DENV) types 1-4, West Nile virus, Langat virus, Omsk hemorrhagic fever virus and others that cause encephalitic or hemorrhagic disease. DENV binds the cell …
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Evaluation of a Tetravalent DNA Vaccine against Dengue: Integrating Biochemical Studies on Dengue Virus Envelope Protein to a Domain-Based Antigen Design.
Dengue virus (DENV) is among the most important mosquito-borne human pathogens worldwide. Concerns regarding the effectiveness of Dengue vaccines together with emergence of Zika virus (ZIKV) have reignited the interest for new vaccines using alternative approaches. Given that the envelope …
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Metabolomics-based diagnosis and prognosis of dengue virus infections and NS1 antigen detection for diagnosis and surveillance in humans and mosquitoes
… Aedes aegypti is the principal vector of DENV, although Aedes albopictus and other Aedes species have been reported to be able to transmit it. Improved surveillance methods for DENV in mosquito populations would be of great value for public health and vector control programs and would …
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Drivers of Dengue Within-Host Dynamics and Virulence Evolution
… with one of the virus's four serotypes (denoted DENV-1 to 4) may be silent, result in symptomatic dengue 'breakbone' fever, or develop into the more severe dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Extensive research has therefore focused on identifying factors that influence …
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Evaluation of Chikungunya Virus Infectious Events in Aedes Albopictus LR and Aedes Aegypti WE Mosquito Vectors
… dengue virus serotype-2, New Guinea C strain (DENV-2 NGC) utilizing three approaches: 1) CHIKV infection with subsequent DENV-2 infection, 2) DENV-2 infection with subsequent CHIKV infection, and 3) simultaneous infection with CHIKV and DENV-2. Simultaneous infection of these mosquitoes with …
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Yellow Fever: Role of Heterologous Flavivirus Immunity on Urban Emergence
… flavivirus immunity, specifically from dengue (DENV) and Zika (ZIKV) viruses, limits YFV viremia and transmission by Ae. aegypti. We infected cynomolgus macaques with DENV or ZIKV, then challenged them 6-9 months later with YFV. We then measured viremia and disease, and allowed Ae. aegypti …
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INVESTIGATING THE ROLE OF DENGUE-SPECIFIC IMMUNITY IN PROTECTION AND DISEASE USING SYMPTOMATIC MOUSE MODELS
Dengue virus (DENV), consisting of four distinct serotypes (DENV1-4), is a public health concern due its prevalence and severity. Development of therapeutics and vaccines has been hampered by a lack of understanding of disease pathogenesis and suitable animal models. Our laboratory has reported …
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Characterization of Host Factors and Anti-viral Compounds for Diverse Mosquito-borne Flaviviruses
… to identify scores of novel dengue virus (DENV) human host dependency factors (HDF) and identified more than 20 potential anti-Zika virus (ZIKV) therapeutics. </p><p>Two genes in particular, TTC35 and TMEM111, strongly inhibited DENV infection and, based on comparisons with published …
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