Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"DENND1B"”.
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From genomics to function: Canine genetics highlight novel mechanisms of obesity and related traits
… which had identified DENN domain containing 1B (*DENND1B*), a protein involved in trafficking. Cross-species evidence that genomic variation in human *DENND1B* alters expression in the hypothalamus suggested it may regulate MC4R signalling. *DENND1B* and *MC4R* were then shown to be expressed in …
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Understanding the Genetic Basis of Obesity: Lessons from Man’s Best Friend
… obesity, including genes *CDH8*, *CARD11* and *DENND1B*. Variants in *CSNK1A1* were also found to be associated with monogenic cases of severe, early onset obesity in humans. Carriers were pursued through familial investigation and deep clinical phenotyping. Further, a canine GWAS association of …