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Showing 1 to 2 of 2 for “"DEAR1"”.
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Investigation of Genetic Alterations In Emt Suppressor, Dear1, Through Pan-Cancer Analysis and Ultra-Deep Targeted Sequencing In Ductal Carcinoma In Situ
… discovered a novel TRIM family member, <em>DEAR1</em> (<em>Ductal Epithelium Associated Ring Chromosome 1, annotated as TRIM62)</em> within chromosome 1p35.1, that is mutated and homozygously deleted in breast cancer and whose expression is downregulated/lost in DCIS. Previous work has shown …
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The Role of Tumor Suppressor Dear1 In The Acquisition of Mammary Stem/Progenitor Cell Properties
… transition (EMT) program. <em>DEAR1</em> is a tumor suppressor gene which is mutated, undergoes loss of heterozygosity in breast cancer, and is downregulated in DCIS lesions and IDC. DEAR1 regulates acinar morphogenesis and cell polarity and is a negative regulator of …