Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"DEAF-1"”.
-
THE ROLE OF THE TRANSCRIPTION FACTOR DEAF-1 IN PROSTATE FUNCTION
Deformed epidermal autoregulatory factor-1 (DEAF-1) is a mammalian transcription factor and is associated with of fetal development, human depression, and cancer. DEAF-1 knock out mice were generated using conventional gene knockout methods to study the standard null phenotype. Deaf-1 is necessary …
-
ELECTROPHYSIOLOGICAL INVESTIGATION OF HIPPOCAMPAL SYNAPTIC PLASTICITY IN DEAF-1 KNOCK-OUT MICE
… learning test. Abnormal mutation in the human deaf1 gene has been previously reported to be associated with ID. Previous behavioral studies in mice with a brain specific conditional neuronal knock outs (NKO) of deaf 1 gene exhibited memory deficit and anxiety-like behavior. These deaf 1 NKO …
-
Identification And Functional Analyses Of Novel Protein Interactions And Post-Translational Modifications For The Transcription Factor Deformed Epidermal Autoregulatory Factor-1.
Deformed Epidermal Autoregulatory Factor-1 (DEAF-1) is a transcription factor that binds TTCG motifs and has roles in fetal development, clinical depression and cancer. In order to further our understanding of the DEAF-1 protein, this study characterizes previously unidentified DEAF-1 interacting …
-
5-HT1A receptor expression : Studies in postmortem tissue and characterisation of a model system.
… with depression and suicide. The nuclear DEAF-1 related (NUDR) protein represses the 5-HT[1A] promoter region hence regulating both 5-HT[1A] transcription and receptor expression. The project involved undertaking a post-mortem study to determine any association between the 5-HT[1A] …