Global ETD Search
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Showing 1 to 8 of 8 for “"DDX3X"”.
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Regulation of human sex-linked homologs DDX3X and DDX3Y and phenotypic consequences
The X-linked gene DDX3X and its Y-linked homolog DDX3Y comprise one of 17 gene pairs retained on the human X and Y chromosomes during their evolution from ordinary autosomes; both genes are widely expressed in human tissues. Mutations of DDX3X and DDX3Y result in a wide range of sex-dependent …
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Elucidating the functions of RNA helicases DDX3X and DDX3Y in normal and malignant B cells
DDX3X is an RNA helicase involved in multiple stages of RNA biogenesis, the most well-studied being as a regulator for translation. Its Y chromosome paralogue, DDX3Y shares 92% amino acid conservation. DDX3X is ubiquitously expressed and considered pan essential. While DDX3Y is widely transcribed, …
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Role of DDX RNA helicases in cancer cells
… work was to investigate the functions of human DDX3X and DDX54 RNA helicases, particularly in in vitro cancer models. To provide insight into their molecular functions, I identified RNAs bound by DDX3X and DDX54 in breast cancer (MCF7) cells by performing iCLIP experiments. This generated two …
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Dissecting the role of RNA helicase DDX3X in mRNA translation and B-cell function during immune responses
… Mutations in DEAD-box helicase 3X (DDX3X) have previously been found in B-cell lymphomas driven by the transcription factor MYC. Reduced DDX3X function buffers the effect of MYC on the upregulation of global translation, ultimately lowering the levels of proteotoxic stress and …
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The role of the DEAD box Helicase DDX3X in Anti-‐Viral Signalling Pathways Mediated by the Kinase IKKα.
The human DEAD-box RNA helicase DDX3X has previously been shown to be involved in innate immune signalling in pathways mediated by IKKε and TBK1. In this work we show that DDX3X is also involved in pathways independent of these kinases, and functions by interacting with two related kinases IKKα and …
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The role of human DEAD-box protein DDX3X in the activation and function of Estrogen Receptor-alpha
The human DEAD-box RNA helicase DDX3X was shown to be involved in innate immune signalling pathways mediated by IKKε and TBK1. Interestingly, both DDX3 and IKKɛ have independently been shown to act as breast cancer oncogenes. In breast cancer, DDX3 expression was shown to be upregulated and linked …
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Using S. pombe to Study the Biological Roles of the Histone Deacetylases Sir2 and Clr3 and the DEAD-Box RNA Helicase Ded1
… mutations of the DEAD-box RNA helicase DDX3X, homolog of fission yeast Ded1, in translational control. Heterochromatin in fission yeast is characterized by hypoacetylation as well as methylation of histone H3 on lysine 9 (H3K9me). Heterochromatin assembly can now be separated into three …
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Translational regulation in aggressive B-cell lymphomas
… that loss-of-function mutations in RNA-helicase (DDX3X) promote early development of MYC-driven lymphoma by buffering the effects of MYC on translation of ribosomal proteins and the rate of global protein synthesis. Finally, I explore a genome-wide distribution of translating ribosomes to study …