Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"DDX1"”.
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The role of DEAD-box helicase 1 in humoral immune responses
… the RNA-binding protein DEAD-box helicase 1 (DDX1) is implicated in targeting the mutagenic enzyme Activation-Induced Cytidine Deaminase (AID) to Ig loci to initiate CSR. The aim of this project was to interrogate further the role of DDX1 during humoral immune responses, to understand whether …
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The PHD finger protein 5 is a part of the spliceosome and acts as a DNA-binding protein
Vier Proteine: U2AF35, SRp40, mDomino und Ddx1 wurden durch Screening Yeast-two hybride-Bibliothek als Partner des PHF 5a-Protein gefunden. Proteininteraktionen wurden in-vitro und in-vivo bestätigt. Die für Bindungen verantwortlichen Domäne wurden als RS Domäne (reich an Arginin-Serin) …
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Identification of Familial Wilms Tumor Predisposition Genes Using Whole Genome Sequencing
… 570kb germline duplication including <em>NBAS, DDX1, MYCN </em>and <em>MYCNOS</em> was identified in 4% of families, as well as germline missense mutations in <em>DICER1 </em>(4% of families) and <em>SPHK2</em>. Functional studies demonstrate that the missense mutation identified in <em>SPHK2 …
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Functional and structural investigation of spliceosomal snRNPs
… vier Komponenten, einer DEAD-box Helikase DDX1, sowie den Proteinen HSPC117, Family with sequence similarity 98/member B und CGI-99. Die Assoziation dieses Komplexes mit SF3b Partikeln wird diskutiert. Um das Wissen über das Protein Snu17p und seiner Interaktionspartner zu erweitern, …