Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"DDIT3"”.
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Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3
… that cause the fusion of the FUS and DDIT3 genes and expression of a chimeric FUS-DDIT3 oncoprotein. The aim of this thesis was to functionally characterize the FUS-DDIT3 fusion oncoprotein and the normal FUS, EWS, TAF15 and DDIT3 counterparts. To understand the involvement of DDIT3 in …
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The unfolded protein response regulates hepatocellular injury during the pathogenesis of nonalcoholic steatohepatitis
… the transcription factors CHOP (GADD153/DDIT3) and NF-κB, leading to increased expression and secretion of cytokines such as TNFα and IL-8 that contributed to hepatic cell death and inflammation. Depletion of either CHOP or the RELA subunit of NF-κB in hepatocytes alleviated autophagy and …