Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"DCIS"”.
-
Cooperative Genomic Events Driving Mutant TP53-Driven DCIS Progression
<p>Ductal carcinoma in situ (DCIS) is a mammary lesion characterized by abnormal epithelial cells occurring in mammary ducts while still being confined to the luminal space. Not all DCIS becomes invasive, and no strategy currently exists in patients to stratify indolent DCIS from DCIS at risk of …
-
Decoding Breast Cancer Development Through Single Cell and Spatial Genomics
<p>Ductal carcinoma in situ (DCIS) is a preinvasive breast cancer in which cancer cells remain confined within the lumen of ducts. With the adoption of mammography, DCIS diagnoses have risen significantly, with approximately 50,000 new cases each year in the U.S. While 10-30% of DCIS patients …
-
Identification and characterisation of non-coding RNAs involved in ductal carcinoma in situ
Ductal carcinoma in situ (DCIS) is an early form of breast cancer, the most common cancer in women worldwide. DCIS can develop into potentially fatal invasive disease, but studies show that less than half of all cases progress if untreated. Currently, most patients receive surgery, as there is no …
-
Analysis of gene expression alterations in premalignant progression from normal mammary epithelium to ductal carcinoma in situ by multiple orthogonal tools
<p>Mammary ductal carcinoma in situ (DCIS) is being found in great numbers of women due to the widespread use of mammography. The molecular and genetic changes underlying the progression from normal breast tissue to DCIS are not clearly understood. The goal of the present study was to determine …
-
Investigation of Genetic Alterations In Emt Suppressor, Dear1, Through Pan-Cancer Analysis and Ultra-Deep Targeted Sequencing In Ductal Carcinoma In Situ
<p>Ductal carcinoma in situ<strong> (</strong>DCIS) is thought to be one of the earliest pre-invasive form of and non-obligate precursor to invasive ductal carcinoma (IDC). There is an urgent need to identify predictive and prognostic biomarkers for breast cancers with a heightened risk of …
-
BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY
… not well understood. Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer which could progress to or recur as invasive breast cancer. To identify the novel regulators of DCIS progression, we performed gene expression analysis of syngeneic cell lines MCF10A, DCIS.com and …
-
Investigating Invasion In Ductal Carcinoma In Situ With to pographical Single Cell Genome Sequencing
<p>Synchronous Ductal Carcinoma in situ (DCIS-IDC) is an early stage breast cancer invasion in which it is possible to delineate genomic evolution during invasion because of the presence of both in situ and invasive regions within the same sample. While laser capture microdissection studies of …
-
Context in Space The Value of Contextual Information in the Presentation of Digital Cultural Items
… such as photographs, paintings, or artefacts, DCIs offer a unique opportunity to conserve cultural information, enhance accessibility via the internet, and provide innovative means of interaction that significantly enriches visitor learning experiences. Despite the potential benefits of DCIs, …
-
Investigating The Ecology and Evolution of Normal Breast Tissues and Breast Cancer With Single Cell Genomics
… stage breast cancer, Ductal Carcinoma In Situ (DCIS). DCIS is the most common form of pre-invasive breast cancer and despite treatment, a small fraction (5-10%) of DCIS patients present with invasive disease many years later. A fundamental question is whether the invasive disease recurring in …
-
ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION
… in normal to ductal carcinoma in situ (DCIS) progression. For this, we first analyzed the expression profile of various lipogenic genes using an expression microarray and found that CSCs from DCIS.com showed significantly higher level of ATP-citrate lyase (ACLY), acetyl-CoA carboxylase …
-
Numerische Chromosomen-Aberrationen im Carcinoma ductale in situ der Mamma unter besonderer Berücksichtigung neuerer Klassifikationen
Das duktale Carcinoma in situ (DCIS) der Mamma stellt eine Neoplasie mit sowohl heterogener Morphologie als auch variierendem biologischen Verhaltens dar. Dies führte in der Vergangenheit zur Etablierung zahlreicher pathohistologischer Klassifikationssysteme mit dem Ziel, das Risiko einer malignen …
-
The Role of Tumor Suppressor Dear1 In The Acquisition of Mammary Stem/Progenitor Cell Properties
… in America. Ductal carcinoma <em>in situ</em> (DCIS), one of the earliest pre-invasive forms of invasive ductal carcinoma (IDC), has a 30-50% risk of progressing to IDC. Understanding the mechanisms regulating progression from DCIS to IDC would help identify biomarkers to stratify patients at …
-
Deciphering Genomic Evolution: From Early Breast Cancer Stages to Invasive Carcinoma
… the evolution of ductal carcinoma in situ (DCIS) to invasive forms such as invasive ductal carcinoma (IDC) at the individual patient level. DCIS is considered a non-obligatory precursor of IDC, being the predominant form of breast cancer detected and comprising approximately 80% of all …
-
Bluttest statt Mammografie-Sreening?
… Analysiert wurden FFPE-Tumorgewebeproben von DCIS, B2/B3-Läsionen sowie frühen invasiven Mammakarzinomen verschiedener molekularer Subtypen. Der Schwerpunkt liegt auf vier in der Literatur beschriebenen CpG-Markern: cg21501525 (TSHZ3), cg20072171 (FEZF2), cg16304215 (OTP) und cg23035715 …
-
The Role of TBX3 In Early Breast Cancer Progression
… in the pre-invasive ductal carcinoma in situ (DCIS) and size of the invasive focus. Additionally, there was a positive correlation between TBX3/SLUG, and TBX3/TWIST1 expression by IHC in the invasive carcinoma. Pathway analysis of transcriptomics data revealed altered expression of several …
-
Krūties carcinoma in situ tipai, diagnostika, gydymas ir prognozė /
… of two subtypes: ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS). Breast carcinoma in situ is most commonly detected by breast cancer screening and diagnostic methods. The main imaging techniques are mammography, which may detect indistinct masses in the breast or …
-
Ipsilateral and concurrent breast cancer and atypical ductal hyperplasia: Does atypia also need surgical excision?
… with 9 cases to ductal carcinoma in situ (DCIS) and 2 to invasive breast cancer (IBC). The most common associations with upgrade were the presence of ipsilateral DCIS over IBC (p=0.034), using ultrasound guidance for biopsy of ADH (p=0.019), and the presence of cell necrosis in the ADH …
-
Acidic Pericellular Ph: Effects On Proteolysis And Gene Expression As Determined In 3d Models Of Breast Carcinoma
… to acidic pH in ductal carcinoma in situ (DCIS). We have found that STAT1-directed signaling is up-regulated in response to acidic pH extracellularly. Its role in altering glycolytic pathways suggests an important role for this transcription factor in the development of an acidic …
-
Ergebnisse der Abklärung klinisch nicht palpabler mammographischer Veränderungen der Mammaa
… sich auf in 41 (30%) in situ Veränderungen (39 DCIS, 2 LCIS), 8 (6%) Rezidive und 89 (64%) invasive Karzinome (63 invasiv duktal, 10 invasiv lobulär, 16 sonstige invasive). Von den 89 invasiven Karzinomen sind 73 (82%) pT1-Tumore, 58 (68%) lymphknotennegativ, nur 1 (1%) hat bereits …
-
Role of cyclin D1 as an estrogen receptor cofactor and the influence of hypoxia on estrogen receptor regulation, with focus on prognositic and treatment predictive features in breast cancer
… was also strongly linked to ER downregulation in DCIS and invasive breast cancer and caused ER downregulation in breast cancer cell lines. Interestingly, hypoxic cells were less differentiated, showing changes in morphology, proliferation and cytokeratin 19 expression. The hypoxia induced ER …
Page 1 of 2