Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"DCE-MRI"”.
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Measurement of The Vascular Input Function In Mice For Dce-Mri
DCE-MRI is an important technique in the study of small animal cancer models because its sensitivity to vascular changes opens the possibility of quantitative assessment of early therapeutic response. However, extraction of physiologically descriptive parameters from DCE-MRI data relies upon …
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Characterization of Biomaterials for Regenerative Medicine via Computational Fluid Flow Analysis of Dynamic Contrast Enhanced – Magnetic Resonance Imaging (DCE-MRI) Images
… Contrast Enhanced – Magnetic Resonance Imaging (DCE-MRI) and computational analysis of the images via MATLAB. The analysis was utilized to analyze the fluid flow through several different biomaterial types, allowing for observational comparison between biomaterial groups. Overall, this method for …
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Improved Techniques For Acquisition and Analysis of Dynamic Contrast-Enhanced Magnetic Resonance Imaging For Detecting Vascular Permeability In The Central Nervous System
… contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive technique for quantitative assessment of the integrity of blood-brain barrier and blood-spinal cord barrier (BSCB) in the presence of central nervous system pathologies. However, the results of DCE-MRI show substantial …
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Dynamic Contrast-Enhanced MRI and Diffusion-Weighted MRI for the Diagnosis of Bladder Cancer
… the abilities of 3T dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DWI) to improve the detection and staging and to enable the prediction of chemotherapeutic response in bladder cancer. A total of fifty-three patients were enrolled in the study. Different inclusion criteria …
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Methods for the Prediction of Osteoradionecrosis resulting from Head and Neck Cancer Radiation Therapy
… contrast enhanced magnetic resonance imaging (DCE-MRI), and the change in pre- and post-RT DCE-MRI. In the first project, several machine learning and deep learning methods were compared to predict binary ORN status based on treatment dose. This project found that the machine learning …
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Quantification Of Vascular Parametric Indices Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging
… contrast-enhanced magnetic resonance imaging (DCE-MRI) is a non-invasive method used to evaluate the biological activity in early clinical trials of novel drugs targeting the tumor vasculature using gadolinium-DTPA (Gd) as a contrast agent. However, it has some limitations, such as …
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Combination therapy studies with the vascular disruptive agent combretastatin-a4-phosphate (CA4P)
… of blood flow related dynamic contrast enhanced MRI (DCE-MRI) parameters between different patients and in lesions within patients on the A5B7 study. Increases in CO (mean +14%, p=0.026) occurred after CA4P whilst falls in tumour Ktrans values were seen (mean -25.1%; p=0.011). There was no …
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The analysis of dynamic contrast-enhanced magnetic resonance imaging data: treatment effects, sampling rates and repeatability
… contrast-enhanced magnetic resonance imaging (DCE-MRI) data, primarily by means of pharmacokinetic models, in order to yield parameters which reflect the physiological properties of tumours. Historically, these analysis procedures have been complicated by varied sources of error, both …
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Analysis of dynamic contrast enhanced MRI datasets
… analysis of 4D dynamic contrast enhanced MRI datasets (DCE-MRI) of the habd and wrist relating to rheumatoid arthritis (RA) studies. In DCE-MRI, sequences of images are acquired from the joints over time, during which a contrast agent pre-injected into a patient enhances disease affected …
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Towards image registration of dynamic contrast enhanced MRI using deep learning
Dynamic contrast enhanced (DCE)-MRI is a quantitative imaging technique used to monitor microvascular perfusion. It involves rapidly acquiring multiple T1-weighted images over a few minutes whilst injecting a contrast agent, which causes a rapid increase in image intensity. Each type of tissue …
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Visual exploration of multivariate data in breast cancer by dimensional reduction
… data reduction for the visual exploration of DCE-MRI and DNA microarray data in breast cancer. Algorithms for dimensional data reduction aim to compute low-dimensional projections of high-dimensional data while best preserving the data topology. In this work several algorithms for dimensional …
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Quantification of cardiac magnetic resonance imaging perfusion in the clinical setting at 3T
Dynamic contrast enhanced (DCE) cardiac magnetic resonance imaging (MRI) is well-established as a non-invasive method for qualitatively detecting obstructive coronary artery disease (CAD) which can impair myocardial blood flow and may result in myocardial infarction. Mathematical modelling of …
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Dynamic Contrast-Enhanced MR Microscopy: Functional Imaging in Preclinical Models of Cancer
<p>Dynamic contrast-enhanced (DCE) MRI has been widely used as a quantitative imaging method for monitoring tumor response to therapy. The pharmacokinetic parameters derived from this technique have been used in more than 100 phase I trials and investigator led studies. The simultaneous challenges …
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Flexible Radial Data Acquisition and Image Reconstruction Strategies for Breast Magnetic Resonance Imaging
… contrast-enhanced magnetic resonance imaging (DCE-MRI) has a high sensitivity (71- 100%) for detecting breast cancers. DCE-MRI is approximately twice as sensitive as mammography for patients who are genetically predisposed to breast cancer, who have an elevated lifetime risk (up to 85%) of …
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Functional Magnetic Resonance Imaging of Breast Cancer
… examines the use of magnetic resonance imaging (MRI) techniques in the detection of breast cancer and the prediction of pathological complete response (pCR) to neoadjuvant chemotherapy (NACT). This thesis compares the diagnostic performance of diffusion-weighted imaging (DWI) models in the breast …
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Quantitative Magnetic Resonance Imaging For The Early Prediction of Treatment Response In Triple Negative Breast Cancer
… <p>Quantitative Magnetic Resonance Imaging (MRI) may be used to probe and measure aspects of the perfusion, diffusion, and mechanical properties of a cancer and its surroundings. In the research setting, several quantitative MRI biomarkers have shown potential for early prediction of response …
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Quantitative Imaging For Precision Medicine In Head and Neck Cancer Patients
… contrast enhanced magnetic resonance imaging (DCE-MRI), overall survival using computed tomography (CT)-based radiomics, and overall survival using positron emission tomography (PET)-based radiomics. From DCE-MRI, where T1-weighted images are serially acquired after injection of contrast, …
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Evaluation of tumour perfusion and fibrosis in mouse models of pancreatic ductal adenocarcinoma, using MRI
… Imaging techniques (Dynamic ContrastEnhanced (DCE-) MRI, Magnetisation Transfer Imaging (MTI)) and SHG microscopy to evaluate the perfusion properties and fibrosis of three different mouse models of PDA: spontaneous KPC tumours, allografts initiated by transplantation of pancreatic tumour cells …
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Mechanisms of vascular cognitive impairment in cerebral small vessel disease and stroke
… focusses on two longitudinal studies, the ‘PET-MRI-SVD’ and ‘Rates, risks and routes to reduce vascular dementia’ (R4VaD), which involved a CSVD (n = 77) and stroke (n = 201) cohort respectively. Multimodal neuroimaging data were acquired in both studies, including structural magnetic resonance …
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Identifying Tumor Vascular Permeability Heterogeneity Using Reduced Encoding Techniques
… imaged with fast T1-weighted gradient echo DCE MRI following a Gd-DTPA injection, there is a window of resolutions that detects similar PS ""hot spots"" compared to those obtained from the clinical imager resolution. The top five PS ""hot spots"" obtained from 469 mum resolution FFT are …
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