Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"DC-SIGN"”.
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Establishing the Role of DC-SIGN and Glycoprotein H for KSHV Entry in B Lymphocytes
… KSHV glycoprotein gH and cell surface receptor DC-SIGN.</p> <p>The first aim of this project will investigate whether the cell surface receptor, DC-SIGN, is required for viral entry of KSHV on tonsillar B lymphocytes. Various approaches will be performed. First, characterization of tonsillar B …
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Interaction between DC-SIGN and DC-SIGNR with HHV-8 (LANA-1) and HIV-p24 in Castleman disease
… aim of the study was to determine the role of DC-SIGN, DC-SIGNR, p24 and HHV-8 (LANA-1) in Castleman disease. Our objectives were to identify the presence of DC-SIGN and DC-SIGNR in HHV-8 infected cells, determine whether HHV-8 and p24 (HIV) co-infection occurs in the same cells and to …
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Characterisation of α4β7and DC-SIGN reactivity of HIV-1 subtype C transmitted founder variants compared with chronic infection controls
Includes bibliographical references.
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The impact of HIV-1 subtype C Envelope N-glycosylation on DC-SIGN meditated modulation of DC function to facilitate transmission or enhance viral pathogenesis
… could affect interactions between Env and DC-SIGN of dendritic cells (DCs), activating alternative signalling pathways which stimulate the release of different immune modulators. We generated pseudovirus of eighteen Env clones (PSVs) with variable number and position of potential N-glycan …
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Intrahost evolution of HIV-1 phenotypes
… ability, mediated by the C-type lectin DC-SIGN, at end-stage disease. In addition, end-stage R5 HIV-1 were more sensitivity to certain broadly neutralizing antibodies. Furthermore, phenotypic alterations correlated with the decline in CD4+ T cell count during development of …
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Manipulation of the Rift Valley Fever Virus M-Segment for Vaccine Development
… Gc, and determine the roles of the N-glycans in DC-SIGN-mediated infection. The results determined that the single N-glycan site within Gn, at nt. 438, was N-glycosylated and three sites within Gc, at nt. 794, 1035, and 1077; are N-glycosylated. We also noted that the doublet band of Gc is …
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Role of microRNA-155 in dendritic cells and macrophages: MiR-155 directly targets PU.1 and IL13Rα1
… essential in myelopoiesis and dendritic cells (DCs) that favours a Th<sub>2</sub> profiling; moreover, PU.1 had been shown to regulate the transcription of DC-SIGN (Dendritic Cell-Specific ICAM-3 Grabbing Non-integrin 1) which is a pathogen receptor expressed in DCs controlled by Th<sub>2</sub> …
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Biophysical Studies of Pathogen Recognition by C-Type Lectins
… cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) and the dendritic cell-specific ICAM-3 grabbing nonintegrin related protein (DC-SIGNR). The lectin architecture comprises of the neck region that presents the carbohydrate recognition domains (CRDs) in a cluster of the C-terminus. The neck …
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A novel method of generating Dendritic cells in vitro using the KG-1 cell line and its use as a model for testing effects of lactic acid bacteria
Dendritic cells (DCs) are prime mediators of innate and adaptive immunity. In humans the DC population comprise only 0.1% of all leukocytes, making their isolation and ex vivo manipulation difficult. Since study of DC activity in vitro requires large numbers of DCs to be readily available, a cell …
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Role of Vitamin-D3 and Retinoic Acid In A Human Thp-1 Macrophage Model of Mycobacterium Tuberculosis Infection
… on THP-1 macrophage (Mannose receptor and DC-SIGN) that increased mycobacterial uptake but inhibited the<br />subsequent intracellular growth of Mtb by inducing reactive oxygen species (ROS) and autophagy. RAVD also enhanced antigen presenting and homing receptors in THPs that suggested an …
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Interpretable Supervised Learning and Graph-Based Optimization for Glycan-Lectin Binding
… a result, there is particular interest in the design of highly specific glycan binders to critical lectins such as dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN). However, insufficient knowledge of the binding specificity of lectins, combined with the enormous structural complexity …
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Mononuclear phagocyte activation and its role in HIV-1 pathogenesis
… M2a cells efficiently transmitting HIV-1 via a DC-SIGN dependant mechanism. In a cohort of treatment-naive AIDS patients, <i>in vivo</i> activation of circulating monocytes and intestinal macrophages was strongly associated with HIV-1 pathogenesis. Monocyte activation in these patients was …
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SELECTIVE GLYCOMIMETIC LIGANDS OF C-TYPE LECTIN RECEPTORS
… approach to selectively target the C-type lectin DC-SIGN and its homologue L-SIGN, which are involved in the recognition of several viruses (e.g. HIV-1, Ebola, Dengue, SARS-CoV-2). A library of monovalent mannose-based glycomimetic ligands has been synthetized by varying the nature and the …
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Mechanisms of Innate Immune Dysfunction During Mycobacterium tuberculosis and HIV Co-infection
… etiologic agent of Tuberculosis (TB), remains a significant public health threat causing over 1.4 million deaths annually. People living with HIV are among the most susceptible to contracting or reactivating Mtb infection due to a deterioration of essential immunity during co-infection. Although …
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Investigating the susceptibility of foreskin myeloid cells to ex vivo HIV infection
… for maturation, and the mannose receptor, DC-SIGN and Siglec-1 as HIV attachment factors and (iii) Investigating the HIV susceptibility of foreskin epidermal cells using an optimised ex vivo pluricellular foreskin infection model of suspension cells. Methodology: Foreskin specimen were …
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Aktivierung von Endothelzellen durch Plasmodium falciparum-infizierte Erythrocyten und Charakterisierung potentieller Adhäsionsrezeptoren
… node specific ICAM-3 grabbing nonintegrin (LSIGN), ein Homolog zu dem C-Typ Lektin Dendritic cell specific ICAM-3 grabbing nonintegrin (DC-SIGN), wird in der Leber auf sinusoidalen Endothelzellen exprimiert. Der Oberflächenrezeptor L-SIGN vermittelt die Endocytose von mannosehaltigen …
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Novel approaches towards vaccine developments against porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus
… macrophages (PIMs), and dendritic cells (DCs) are the main targets for PRRSV replication. The role of PRRSV-DCs interaction is not fully understood, and current research focuses on the production and regulation of interferons through DC-SIGN receptors. In this study, we evaluated the …
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Síntesis de compuestos organoselénicos derivados del hidroxitirosol. Determinación de su actividad como antioxidantes
… al que en base a datos espectroscópicos se ha asignado la estructura del selenonio 42. (Esquema 8) Esquema 8 Una ruta alternativa para la obtención del diselenuro 43 consiste en la acetilación de los grupos hidroxilo de catecol en el bromoderivado 6, seguida de tratamiento con la sal de selenio …