Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"DC maturation"”.
-
The effects of ES-62 on DC maturation and effector function
… functions. To date, more than 6 different DC subtypes have been identified that arise from at least two different cell lineages. These subtypes are not only phenotypically distinct but they are also thought to perform different functions and be restricted to certain lymphoid organs. Thus, …
-
Biomaterials for tissue engineering for rheumatoid arthritis based on controlling dendritic cell phenotype
… to understand the response of dendritic cells (DCs) to different biomaterials upon contact and identify biomaterials suitable for use in tissue engineering constructs for rheumatoid arthritis (RA) applications. Differential levels of functional DC maturation were observed depending on the type …
-
Regulation of Dendritic cell function by the ocular microenvironment
… maintains an immature dendritic cell (DC) phenotype, whereas in intraocular inflammation (uveitis) this regulation fails, permitting full DC maturation leading to the production and recruitment of pathogenic effector T cells to the eye. Using an in vitro model of DC function, I observed …
-
Bidirectional Natural Killer Cell and Dendritic Cell Interactions in HIV-1 Pathogenesis
Natural killer (NK) and dendritic cell (DC) interactions are pivotal for the development of immune responses, which lead to bidirectional NK:DC activation. In HIV-1 infection, both NK cell and DC function are impaired, resulting in dysfunctional NK:DC crosstalk. We demonstrate that NK:DC …
-
Innate Immunity to Listeria monocytogenes Infection: Regulation of Dendritic Cell and Neutrophil Responses by MyD88 and the Type I IFN Receptor
… variety of cell types including dendritic cells (DC). Our laboratory and others have shown that optimal DC maturation occurs when <italic>Listeria</italic> gain access to the host cytosol, and this correlates with protective immunity.
-
The Role of Mesenchymal Stromal Cells in Inflammation and Treatment of Pulmonary Fibrosis
… on Jagged 1 signalling. MSC inhibition of DC maturation and antigen presentation was shown to also involve Jagged 1 however IL-6 signalling is also necessary. MSC inhibition of DC maturation resulted in a semi mature or “tolerogenic” DC, expressing lower levels of co-stimulatory markers. …
-
Characterisation of the immunomodulatory properties of human natural killer T cells
… as tailored adjuvants for dendritic cell (DC) based immunotherapy. We established a system to test the immunostimulatory ability of iNKT cell analogues on DC maturation and function. A novel αGalCer analogue α-S-GalCer stimulated iNKT cell line to produce a Th1 biased cytokine response and …
-
A role for polyunsaturated fatty acids in Th1-mediated disease
… of action remains elusive. Dendritic cells (DC) are the most potent antigen presenting cell (APC) and we found that n-3 and n-6 PUFA suppressed IL-12p70 and enhanced IL-10 production rendering the DC less inflammatory. Furthermore, PUFA inhibited DC maturation by impeding the upregulation of …
-
DISSECTING THE ROLES OF DISTINCT DENDRITIC CELL SUBSETS IN THE IMMUNE RESPONSE TO THE INTRACELLULAR BACTERIAL PATHOGEN, LISTERIA MONOCYTOGENES
Dendritic cells (DC) are vital to the development of protective immunity to many pathogens and link the innate and adaptive immune systems. While DC as a whole have been studied extensively and are widely known for their ability to prime naïve T cells, there is much yet to be discovered about DC …
-
The effect of manipulating apoptotic cell uptake on their immunogenicity
… by bone marrow-derived dendritic cells (BMDCs) was determined by CD8+ T cell proliferation assays in vitro and in vivo. Loading BMDCs with apoptotic cells via a PS-independent pathway or through Fc? receptors (Fc?Rs) reduced their ability to induce CD8+ T cell proliferation in vivo, …
-
Unraveling the host innate immune response to a respiratory model of Brucella abortus
… The Centers for Disease Control and Prevention (CDC) categorizes them as class B pathogens due to their zoonotic potential. Currently, there are no efficacious Brucella vaccines for humans available. Very few studies have focused on identifying protective vaccines against respiratory exposure. …
-
Gene Therapy Using Tet-Repressor System to Modulate Prostate Tumor Microenvironment
… generation of fully competent dendritic cells (DCs) that are known to be potent antigen presenting cells and capable of activating naïve T cells. While DCs need to acquire a mature phenotype to induce T cell activation, it is known that the microenvironment of many tumors including prostate …
-
Immunohistochemical Study of Phenotypes of Dendritic Cells in Dental Pulps from Non-Carious and Carious Teeth
Mature dendritic cells (DCs) in inflamed tissues may promote inflammation but the status of DCs in pulpitis is not known. We hypothesized that DC maturation would correlate with carious lesion depth and that CD4+ cells would be found in association with mature DCs. Pulps were collected from teeth …
-
Synthesis of a hydrogel-based vaccine to mimic dendritic cell responses to pathogens
… to the orchestrated response of dendritic cells (DCs) triggered by these immunizations, which includes (1) DC and DC precursor attraction to the immunization site, (2) efficient antigen delivery to class I and class II MHC loading pathways coincident with maturation of DCs, and (3) emigration to …
-
Dendritic Cells in Normal and Inflamed Human Skin
… to be a primary keratinocyte differentiation and maturation disease. Several T cell targeted theraputics were found to reverse disease, and thus subsequent research has focussed on the adaptive immune system, particularly effector CD8+ T cells infiltrating the epidermis. Recent studies, however, …
-
Respiratory infection with the paramyxovirus SV5 results in maturation and cytokine secretion in CD103- and CD103+ dendritic cell subsets.
Dendritic cells (DC) bridge innate and adaptive immunity as the effective activators of naïve T cells. Three signals from DC contribute to the CD8+ T cell activation and acquisition of effector function: 1. peptide/MHC, 2. costimulatory molecules (eg. CD80, CD86), and 3. secreted cytokines (e.g. …
-
Refinement of Subnetwork Discovery Algorithm for Biological Networks
… we apply this improved version of JAM to DC (Dendritic Cell) maturation microarray data and KEGG pathways to study the underlying mechanisms behind the DC maturation process, an essential part of the development of protective immunity to a number of infectious pathogens.
-
The immunomodulatory properties of helminth-derived products on dendritic cell maturation and function
… these responses are induced. Dendritic cells (DC’s) play a crucial role in linking the innate to adaptive arms of the immune system and directing the subsequent immune responses. Here, we report that Fasciola hepatica tegumental antigens (FhTeg) can suppress DC maturation and function. While …
-
The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells
… gD and the heterodimer gHgL. Dendritic cells (DC) are the most potent antigen presenting cells and are likely to encounter the virus early after entry into the host. HSV-1 readily infects DC leading to a series of both morphological and functional changes, and yet the pathway induced by HSV-1 …
-
Mechanism of Chimeric Vaccine Mediated Immune Suppression of Human Dendritic Cells
… to a loss of tolerance. Dendritic cells (DC) interact predominantly with naïve T cells to regulate the delicate balance between immunity and tolerance required to maintain immunological homeostasis. In this dissertation, immature human dendritic cells (iDC) were inoculated with a chimeric …
Page 1 of 2