Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"DARPins"”.
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Engineering of an anti-PAI-1 antibody with tissue specific activation
… of masking domains are described, peptides and DARPins, which I selected against the MEDI-579 paratope. Using human and rodent transcriptomics data, three proteases, renin, hepsin and MMP-7, were identified that appear restricted to the kidney and have a specific cleavage signature. Activation …
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Characterization of the vaccinia virus M1 protein on caspase inhibition and the MVA/5.2KB virus on immunogenicity
… Novel designed ANK repeat proteins (DARPins), are being created to specifically bind proteins, such as caspases, with high affinity. Therefore, information from the study of M1 could potentially aid in DARPin development. Due to the truncation or deletion of multiple viral proteins, …
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Exploring multivalent technologies and strategies for directed protein evolution
… of Designed Ankyrin Repeat Proteins (DARPins). The resulting libraries were subjected to evolution campaigns and the evolved variants emerging from selection rounds, as well as intermediate states, analyzed to address the questions of whether differences in trajectories in sequence …
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Inhibiting Protein-Protein Interactions using Rationally-designed Repeat Proteins
The inhibition of protein-protein interactions (PPIs) presents a major challenge to drug discovery. The properties of consensus-designed tetratricopeptide repeat proteins (CTPRs) make them very amenable to be rationally-designed into potential new PPI inhibitors. This study sets out to investigate …