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Showing 1 to 8 of 8 for “"DARPP-32"”.

  1. Role of DARPP-32 in Breast Cancer Cell Signalling and Migration

    Hansen, ChristianExperimental Pathology2008

    … This thesis describes the identification of DARPP-32 as a novel interactionpartner to DDR1. We demonstrate that DARPP-32 inhibits MCF-7 cell migration and that this effect requires phosphorylation of threonine-34, an event catalyzed by protein kinase A (PKA) and strongly induced by detachment …

    lund Repository record

  2. Age and Sex Differences in the Effects of Nicotine on Tyrosine Hydroxylase Protein Levels and DARPP-32 Phosphorylation at Ser130 in Mice

    Proffitt, Tresa L S2022

    gmu

  3. The Differential Contribution of Striatonigral and Striatopallidal Neurons in Mediating Responses to Therapeutic Agents and Drugs of Abuse: A Dual Role for DARPP-32

    Bateup, Helen S

    … can have profound physiological consequences. DARPP-32 is a dual function kinase/phosphatase inhibitor which has been shown to be a key mediator of signaling in both striatonigral and triatopallidal neurons. A variety of therapeutic agents and drugs of abuse can affect the phosphorylation of …

    rockefeller Repository record

  4. Protein Phosphatase Inhibitor-1 and Cdk5: Of Molecules and Memory

    Nguyen, Baochan2010

    … dopamine- and cAMP-regulated phosphoprotein (DARPP-32) in a cofactor- and N-methyl-D-aspartate (NMDA) receptor-independent manner. Effects on DARPP-32 were Ca2+-mediated and PP-2A-dependent, while effects on inhibitor-1 were nonselectively cation-mediated and either partially PP-2B-dependent …

    utswmed Repository record

  5. THE ROLE OF DOPAMINE D3 RECEPTORS IN THE CONTROL OF ALCOHOL INTAKE

    CAMILLIERI, GIOVANNIUniversità degli studi di Catania2012

    … DA transmission (assessed as phosphorylation of DARPP-32 and GSK3 beta) in striatum and prefrontal cortex. Forced ethanol intake increased the expression of RACK1 and BDNF in both WT and D3R-/-; in WT there was also a robust overexpression of D3R. Thus, increased expression of D3R associated with …

    catania Repository record

  6. Pharmacological inhibition of CK2: the effect of an FDA designated orphan drug on pathology, neuroinflammation, and glial phenotypes in Huntington’s disease

    Pelzel, Ross2026

    … CX-4945 decreased mHtt aggregation, increased DARPP-32 expression and excitatory synapse density, restored homeostatic astrocyte phenotypes and ameliorated neuroinflammation and microgliosis, altogether resulting in improved motor behavior. These results support CX-4945 as a strong candidate …

    umn Repository record

  7. Role of Dopamine D3 receptor in the regulation of memory related genes

    D'AMICO, AGATA GRAZIAUniversità degli studi di Catania2013

    … to the WT mice. Datas showed increased Akt, DARPP-32 and GSK-3B phospshorylation in D3-/- mice, suggesting that this pathaways is involved in raised tPA expression in D3-/- mice.

    catania Repository record

  8. The Role of Cdk5 in the Regulation of Dopamine Neurotransmission, Neuronal Excitability, and Reward-Related Behavior

    Benavides, David Roger2010

    … numerous pathways, including but not limited to DARPP-32, RII-beta, PDE, and MEK1. In summary, these studies identify novel regulatory mechanisms through which Cdk5 controls PKA signaling as well as the interplay between PKA and ERK signaling pathways that regulate motivation and reward-related …

    utswmed Repository record