Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"DAMPs"”.
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Mitochondrial damage-associated molecular patterns (DAMPs) in inflammatory bowel disease
… in IBD is damage-associated molecular patterns (DAMPs) including mitochondrial DNA (mtDNA). It has been recently shown that gut mitochondrial dysfunction can result in loss of epithelial barrier function and the development of colitis. Mitochondrial DAMPs have recently been described as elevated …
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Studies on the Damage Associated Molecular Patterns (DAMPs)-induced Inflammatory Events in the Brain Immune Cells
… and damage-associated molecular patterns (DAMPs). PAMPs are presented by microorganisms, whereas DAMPs include endogenous intracellular molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules that are upregulated upon injury or degraded following tissue …
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The role of mitochondrial DAMPs on the inflammatory response in an <i>in vitro</i> model of canine SIRS
… – termed damage-associated molecular patterns or DAMPs – in helping to initiate and perpetuate this inflammatory response. These findings have yet to be investigated in a large animal model such as dogs. Given the similarities between dogs and humans, and questions regarding the usefulness of …
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Air pollution modeling
… source and meteorological extensive checking. DAMPS condition thus is a dynamic, segmented, source-oriented, deterministic, mesoscale model which keeps track of all air parcels over a 60 by 60 kilometer region. DAMPS updates all receptors hourly and produces three types of graphic output. DAMPS …
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Investigating the ablative and immunomodulatory effects of high frequency irreversible electroporation on osteosarcoma in-vitro
… release of damage-associated molecular patterns (DAMPs), and promotes pro-inflammatory immune activating signatures in macrophages and T cells. Using an in-vitro model, my master's thesis focused on 1) Determining the electric field strength that completely ablates OS cells 2) Evaluating the …
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Toll-like receptor mediated responses to adsorbed damage-associated molecular patterns on biomaterial surfaces
… Damage-associated molecular patterns (DAMPs) are endogenous ligands released by stressed or damaged tissues to stimulate sterile inflammatory responses via Toll-like receptors (TLRs) and other pattern recognition receptors. The work in this thesis explored the contribution of cellular …
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Modulating the Inflammatory Response of Macrophages on Biomaterial Surfaces
… including damage-associated molecular patterns (DAMPs) that are released by cells upon necrosis or when under considerable amounts of stress. The immune response to implanted materials is carried out primarily by macrophages, which recognize DAMPs and other surface-adsorbed proteins with …
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Investigating The Effect Of Chronic Muscle Use And Disuse On Innate Immune Signaling In Skeletal Muscle
… against damage-associated molecular patterns (DAMPs). The objective of this study was to investigate how various metabolic conditions affect innate immune activation and mitochondrial health within skeletal muscle, which has not been fully elucidated. To investigate this, we assessed innate …
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Adaptive Control using IIR Lattice Filters
… design and implement an adaptive controller that damps the structural vibrations induced in a multi-modal structure. The adaptive controller utilizes an adaptive infinite impulse response lattice filter for improved damping over the fixed feedback controller alone. An adaptive finite impulse …
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PRINCESS AND THE PEA: THE IMPACT OF ROUGH TOPOGRAPHY ON DYNAMICS OF LARGE-SCALE SURFACE CIRCULATION PATTERNS
… Results reveal that bottom roughness damps deep-layer velocity and EKE while the surface-layer gyre structure is preserved. The sandpaper model is validated for coarse-grid simulations as it aligns with the resolved topographic cases. Viscosity and wind-forcing set the energy response …
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Investigating the role of toll-like receptor 4 in myocardial ischaemic-preconditioning and ischaemic-reperfusion injury
… Receptor activity is triggered when DAMPs (danger associated molecular pattern molecules) are released from necrotic cells and bind onto the TLR4 receptor complex. Evidence in the last two decades suggests that TLR4 can either exacerbate ischaemicreperfusion injury or trigger a …
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The role of PLK1 in NLRP3 inflammasome activation
… that assembles in response to a variety of DAMPs (Damage-Associated Molecular Patterns) and PAMPs (Pathogen-Associated Molecular Patterns). Activation of the NLRP3 inflammasome leads to pro-inflammatory cytokines (IL-1 and IL-18) release and pyroptosis, an inflammasome-specific form of cell …
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Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection
… and danger-associated molecular patterns (DAMPs) with crucial roles in host defense against microbial infection, autoimmune diseases and cancer. Cytosolic nucleic acids including DNA and RNA originate from pathogens or self-cells, which form major groups of PAMPs and DAMPs. A range of …
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Investigating TLR-4 signalling in response to protein ligands
… endogenous damage associated molecular patterns (DAMPs), such as extracellular matrix (ECM) proteins, for example fragments of fibronectin and tenascin-C. The mechanism by which these proteins interact with TLR-4 and induce signalling is unclear. Proteins from the ECM (fragments FNIII1c, …
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Induction of Immunogenic Cell Death via Nanoparticle-Mediated Dual Chemotherapy and Photothermal Therapy
… of damage associated molecular patterns (DAMPs). NPs were made from biocompatible polymers, poly(lactic acid)-b-poly(ethylene glycol) and bovine serum albumin. Both NPs were loaded with doxorubicin, a chemotherapeutic agent, and indocyanine green, a PTT agent that can absorb the light in …
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JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
… production of inflammatory chemokines and DAMPs such as IL-1β and extracellular ATP. RNA sequencing of murine macrophages co-cultured with infected human tumor cells showed enrichment of chemotactic and pro-inflammatory pathways as well as increased Fc receptor activation following …
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Some principal organizational parameters affecting the capital expenditure process
… this objective were established. The enterprise damps oscillations in its complex interconnected system of objectives to assure relative stability within the limits of the developed primary objective. The damping methods employed by the enterprise place parameters on the capital expenditure …
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Parametric Viscous Analysis of Gust Interaction with Stationary and Elastically Mounted Airfoil
… low-pass filter operator which selectively damps the poorly resolved high-frequency content to retain numerical accuracy and stability over a wide range of flow regimes. The strongly coupled, nonlinear unsteady aerodynamic and structural responses of an elastically mounted airfoil subject to …
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Wall-Jet Turbulence and Mixing Control by Way of a Pulsed Inlet Velocity
… the inlet velocity at a low Sr number of 0.0048 damps turbulence and leads to skin friction reduction. The forced wall-jet experiences a repetitive re-laminarization process that delays transition as well as separation from the wall. A qualitative parametric analysis of the perturbation of the …
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Using Genetic and Pathogeneses Studies to Develop Antiviral and BVDV Vaccine Targets
… our data showed some evidence for the role of DAMPS in viral immunity and replication.</p>
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