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Showing 1 to 8 of 8 for “"DAF-12"”.
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DAF-12: A Novel Drug Target in Parasitic Nematodes
The nuclear receptor DAF-12, first identified in C. elegans, controls nematode species' entry into and exit from metabolically hypoactive resting states. In all of the parasitic species studied thus far, that resting state is the infectious third larval (iL3) stage, and activation of the receptor …
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DAF-12: A Novel Drug Target in Parasitic Nematodes
The nuclear receptor DAF-12, first identified in C. elegans, controls nematode species' entry into and exit from metabolically hypoactive resting states. In all of the parasitic species studied thus far, that resting state is the infectious third larval (iL3) stage, and activation of the receptor …
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Identification of Ligands for the Orphan Nuclear Receptor DAF-12 That Govern Dauer Formation and Reproduction in C. Elegans
The orphan nuclear hormone receptor, DAF-12, plays a central role in the physiology of free-living nematode, C. elegans. DAF-12 is best known for its role in regulating dauer formation, a non-reproductive larval state entered in harsh environments and marked by developmental arrest, stress …
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Nuclear Receptor Controls Nematode Metabolism And Development: Insight Into Man’s Nemesis, the Conqueror Worm
The nuclear receptor DAF-12 plays a central role in controlling the larval development of C. elegans. Activation of DAF-12 by its ligands called dafachronic acids (DAs) commits the nematode to development into reproductive adult, which will otherwise arrest at a diapause stage called dauer. But the …
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Investigating C. Elegans Small-Molecule Signaling Pathways Via 2D-Nmr Based Comparative Metabolomics
… to bind to the Nuclear Hormone Receptor - DAF-12 and here using our approach we identify for the first time, the complete set of DAF-12 ligands in an unbiased and unambigious way. We then continue to investigate the biosynthetic pathway of these ligands and uncover components of the network …
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Neuartige Myosin ATPase-Inhibitoren auf der Basis polyhalogenierter Pyrrolalkaloide und stereoselektive Synthese hormonell aktiver Steroide
… welche Liganden für den hormonellen Rezeptor DAF-12 des Nematoden Caenorhabditis elegans repräsentieren. Die an C-25 R-konfigurierten Säuren waren in der Literatur mit einer deutlich geringeren Aktivität als die 25S-Säuren beschrieben. Die 25R-Steroide waren synthetisch leicht aus kommerziell …
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Effects of Zinc Oxide Nanoparticles on the Pharyngeal Pumping and Neurological Behavior of C. elegans
… at 61.4 [micro]M for 72 hours: ceh-22, ceh-24, daf-12, drp-1, dyn-1, eat-2, eat-5, eat-18, F02A9.4, glc-2, inx-10, lev-11, myo-1, myo-2, myo-5, nas-3, nas-15, nfi-1, pha-1, pha-2, pha-4, sod-1 and unc-2. Overall, a majority of the said genes, 17 out of 23, were significantly upregulated. Genes …
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DRE-1/FBXO11, a Conserved F Box Protein, Regulates Apoptosis in C. elegans and is Mutated in Human Lymphoma
… and cloned this mutant, and found that dre-1 (daf-12-redundant-1) is required for caspase activation in the tail-spike cell. Expression of the dre-1 cDNA in the tail-spike cell rescues the dre-1(ns39) defect in a cell autonomous manner, and expression studies show that dre-1 is expressed in the …