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Showing 1 to 20 of 45 for “"DA neurons"”.

  1. Studies of nicotinic acetylcholine receptors containing α4 and α6 subunits in nicotine-induced synaptic plasticity in brain reward areas

    Engle, Staci

    … nAChRs in ventral tegmental area (VTA) dopamine (DA) neurons are crucial for the rewarding and reinforcing properties of nicotine. Nicotine causes cellular changes in VTA DA neurons, including the enhancement of AMPA receptor (AMPAR) function. This enhancement sensitizes the VTA to excitatory …

    purdue-thes Repository record

  2. Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compacta

    Morris, Paul GeorgeUniversity of Cambridge2018

    Dopamine (DA) neurons of the substantia nigra pars compacta (SNc) have a key role in regulation of voluntary movement control. Their death is a hallmark of Parkinson’s disease, characterised by inhibited motor control, including muscle rigidity and tremor. Excitatory input to SNc-DA neurons is …

    cambridge Repository record

  3. Characterization of Vesicular Monoamine Transporter 2 and Its Role In Parkinson'S Disease Pathogenesis Using Drosophila

    Tito, Antonio Joel, Jr., Zhang, Sheng2017

    … caused by the selective loss of the dopaminergic neurons in the <em>S</em><em>ubstantia nigra</em><em> pars compacta</em> region of the brain. PD is also the most common neurodegenerative disorder and the second most common movement disorder. PD patients exhibit the cardinal symptoms, including …

    uthsc Repository record

  4. Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models

    허, 수희2012

    … the survival of nigrostriatal dopaminergic (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease. MPTP induced degeneration of nigrostriatal DA neurons and glial activation as visualized by tyrosine hydroxylase, macrophage antigen …

    ajou Repository record

  5. Nicotine Alters Gene Regulatory Networks in Dopaminergic Neurons in the Ventral Tegmental Area

    Keller, Renee F.University of Houston2018

    … implicated in the reward pathway. Dopaminergic (DA) neurons originating from the ventral tegmental area (VTA) of the brain are activated by nicotine and form the natural reward pathway that is known to contribute to addiction. In recent years, microRNAs (miRNAs) have been found to …

    houston Repository record

  6. Modificazioni neuronali nella via abenulo-mesencefalica durante l’astinenza da Δ9-tetraidrocannabinolo

    ARONI, SONIAUniversità degli Studi di Cagliari2016

    The mesolimbic dopamine (DA) system, which originates in the midbrain ventral tegmental area (VTA), shows a reduction in its spontaneous activity after chronic cannabinoid exposure and withdrawal, the critical phases of the drug addiction cycle. These adaptive changes, which result from imbalances …

    cagliari Repository record

  7. The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons

    Harms, Ashley Nicole Simpson2010

    … characterized by a loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). A number of studies have implicated chronic inflammation in the pathophysiology of PD; however, it is unclear which inflammatory mechanisms directly contribute to neuronal loss in PD. A …

    utswmed Repository record

  8. Fatty acid ethanolamides pinpoint nicotinic receptors and modulate neuronal excitability through nuclear receptor PPARα

    MELIS, MIRIAMUniversità degli Studi di Cagliari2011

    … nicotine-induced stimulation of VTA dopamine (DA) neuron firing rate through the peroxisome-proliferator-activated receptor-α (PPARα) and to elucidate their mechanism of action in an in vitro brain slice preparation. 2) To determine whether there is an interaction between PPARα and nAChRs in …

    cagliari Repository record

  9. Investigating Parkinson’s Disease human iPSC-derived models through single-cell gene expression

    Patikas, NikolaosUniversity of Cambridge2022

    … protocols of iPSC to midbrain dopaminergic neurons enables the study human midbrain Dopamine(DA) neurons, the primary neuronal group affected in Parkinson's Disease(PD), in-vitro. Despite their increasing adoption and disease modeling potential in neuroscience research, establishing …

    cambridge Repository record

  10. Studies on transient receptor potential vanilloid subtype 1 (TRPV1)-mediated degeneration of mesencephalic cellsin vivo and in vitro

    김, 상룡2011

    … CAP, resulted in cell death of dopaminergic (DA) neurons, as visualized by immunocytochemistry. This in vivo and in vitro effect was ameliorated by the TRPV1 antagonist capsazepine (CZP) or iodo-resiniferatoxin (I-RTX), suggesting the direct involvement of TRPV1 in neurotoxicity. In cultures, …

    ajou Repository record

  11. mRNA EXPRESSION ANALYSIS OF MIDBRAIN DOPAMINE NEURONS IN RESPONSE TO NICOTINE INTAKE DURING MATURATION

    Kanlikilicer, PinarUniversity of Houston2013

    … the dopamine system. The majority of dopamine (DA) neurons are located in the ventral midbrain comprising of the substantia nigra (SN) and the ventral tegmental area (VTA). Nicotine has been suggested as both neuroprotective and neurotoxic on the central nervous system (CNS). For many …

    houston Repository record

  12. The Effect of L-DOPA and Natural Products on Age-Related Motor Deficits and Dopaminergic Cell Survival

    Allen, Erika Nicole2018

    … reversal of motor deficits, striatal dopamine (DA) and DA metabolite levels and the number of DA neurons in the substantia nigra were examined. None of these parameters changed with age or in animals fed resveratrol or pinostilbene diets. However, WBB increased the number of DA neurons in the …

    duquesne Repository record

  13. EFFECTS OF OPTOGENETIC ACTIVATION AND PHARMACOLOGICAL MODULATION OF DOPAMINE NEURONS

    Rice, Remington J2016

    … of dopamine in mesolimbic dopamine neurons. Positive symptoms can be produced in healthy volunteers treated with amphetamine, a psychostimulant drug and dopamine releaser. Conversely, antipsychotic drugs may reduce positive symptoms by blocking dopamine receptors. This study used …

    nmu Repository record

  14. The glial cell line-derived neurotrophic factor family in the olfactory system and brain

    Kaplinovsky, TamilaUNSW, Sydney2015

    … function of many different cell types, including neurons in the central nervous system. The family consists of four ligands [GDNF, neurturin (NTN), artemin and persephin] which bind to four co-receptors (GFRα1-4) and recruit the tyrosine kinase receptor RET into the signaling complex. In vivo, the …

    unsw Repository record

  15. Differential Effects of Parkinsonian Toxins and L-DOPA on Locus Coeruleus and Substantia Nigra Neurons: Implications for Parkinson’s Disease

    Yee, AndrewResearchSpace@Auckland2015

    … symptoms, caused by degeneration of dopamine (DA)-producing neurons of the Substantia Nigra pars compacta (SNc). However, PD patients also suffer from many non-motor symptoms (NMS; eg. sleep disturbance, autonomic dysfunction, depression and anxiety), which cause significant disability and …

    auckland-ms Repository record

  16. Defining the potential of HDAC5 and HDAC9 as therapeutic targets for Parkinson’s disease

    O'Mahony, AdamUniversity College Cork2025

    … of midbrain nigrostriatal dopaminergic (DA) neurons is a pathological hallmark of Parkinson’s disease (PD). DA neuronal degeneration is driven by toxic aggregates of alpha-synuclein (α-syn), a key pathological hallmark of PD. Identification of neuroprotective and disease altering factors …

    cork Repository record

  17. Regulation of Microtubules by Patronin within Drosophila Dendrites

    Brooks, PaulUniversity of Cambridge2020

    … on neuronal development and maintenance. Neurons are the most modular of all cells, comprising of a cell body, axon and dendrites. The development and function of each compartment relies heavily on the cytoskeleton, a major component of which are microtubules, which are required for …

    cambridge Repository record

  18. INVESTIGATION OF ALPHA-SYNUCLEIN/TUBULIN INTERACTION IN PRESYNAPTIC MICROTUBULE DYNAMICS IN DOPAMINERGIC NEURONS

    COMINCINI, ALESSANDROUniversità degli Studi di Milano2023

    … the degeneration and loss of the dopaminergic (DA) neurons of the substantia nigra pars compacta (SNpc) in Parkinson’s disease (PD) are still unknown. Among them, α-synuclein aggregation, mitochondrial impairment, increase oxidative stress and synaptic dysfunction are often indicated as …

    milano Repository record

  19. Molecular and Genetic Analysis of Parkin in Microglia Activation and Inflammation-Related Neurodegeneration

    Tran, Thi Anh2010

    … characterized by the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Genetic mutations account for only 5-10% of PD cases. Oxidative stress and inflammation have both been linked to sporadic PD. Inflammation-induced injury to dopaminergic neurons can be significantly …

    utswmed Repository record

  20. Neuronal and Molecular Adaptations of GABA Neurons in the Ventral Tegmental Area to Chronic Alcohol

    Hales, Kimberly2007

    … alcohol on the excitability and molecular adaptation of GABA neurons of the ventral tegmental area (VTA). GABA neurons are of interest with regards to ethanol intoxication, reinforcement, and dependence due to their widespread distribution and connectivity to mesocorticolimbic dopamine (DA) …

    byu Repository record

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