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Showing 1 to 1 of 1 for “"D324 - Animal pharmacology"”.
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The role of folic acid supplementation on exencephaly induced by maternal exposure to sodium valproate in the TO mouse
… cause spina bifida in humans and exencephaly in animals. The Theiler Outbred (TO) mouse exhibits a low incidence (4.4%) of spontaneous exencephaly at birth. This frequency is enhanced by sodium valproate (VPA), an anticonvulsant drug. Earlier workers have reported that folic acid (FA) …