Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 292 for “"D3"”.
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Supersymmetric gauge theories from D3-branes on singularities
… wall in a theory which can be realized on D3-branes at the apex of the complex cone over the zeroth Hirzebruch surface with the addition of fractional branes. Next, we compute global U(1) charges for the matter fields of the del Pezzo gauge theories and formulate several of their features …
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The absorption of vitamin D3 from soy protein nanoemulsions
… health problem in Saudi Arabia. Inadequate VitD3 status has been associated with several chronic disease conditions such as diabetes, autoimmune disease, infectious disease, cancer, and cardiovascular disease, most of which are present in the Saudi Arabian population. Fortification of foods …
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THE ROLE OF DOPAMINE D3 RECEPTOR IN ALCOHOL ADDICTION AND SCHIZOPHRENIA
… (D1R and D5R) and D2R- like receptors (D2R, D3R and D4R, Seeman et al., 1994). Among dopamine receptors, the dopamine D3 receptor (D3R) has captured the scientific interest because of its restricted distribution in the brain, seemingly related to functions of dopamine associated with the …
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Ontwikkeling van spirocyclische vitamine D3 analoga met potentiële dissociatie van biologische activiteiten
Since the discovery that 1α,25(OH)2D3 (calcitriol), the hormonally active metabolite of vitamin D3, possesses, next to its classical calciotropic activity, also cell differentiating and antiproliferative activities, there has been a search for analogues in which a dissociation of calcemic and other …
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Role of Dopamine D3 receptor in the regulation of memory related genes
… the brain regions in which they are activated. D3 receptors (D3R) are more selectively expressed in the limbic regions, which are associated with cognitive and emotional functions. However, few studies have focused on the effect of D3R deficiency on learning and memory processes and underlying …
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THE ROLE OF DOPAMINE D3 RECEPTORS IN THE CONTROL OF ALCOHOL INTAKE
… seeking behavior. Stimulation of dopamine D3 autoreceptor reduces extracellular levels of dopamine. We tested the hypothesis that dopamine D3 receptor (D3R) gene deletion or its pharmacological blockade counteracts alcohol preference and intake in a long-term voluntary ethanol intake …
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In Silico-Guided Design of Novel-Scaffold Therapeutics Targeting the Dopamine D3 Receptor
… (DFDD), was evaluated employing a dopamine D3 receptor (D3R) crystal structure. Three DFDD approaches - scaffold replacement, ligand building, and MedChem Transformations - were assessed in replacing structural portions of eticlopride, a D2/D3R-specific antagonist, to generate compounds of …
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Implications of dopamine D3 receptor for glaucoma: in-silico and in-vivo studies
… focused on GPCRs and in particular on dopamine D3 receptor as pharmacological target for ocular hypotensive drugs. Cabergoline, bromocriptine, cianergoline and legotrile, classical D2 receptor agonists, have been shown to decrease intraocular pressure. D3 receptor belongs to the D2 class of …
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Model-Guided Transdermal Formulation of 1α,25-Dihydroxyvitamin D3 for Improved Safety and Efficacy
1α,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active ligand of vitamin D receptor (VDR), is useful for the prevention and treatment of various diseases, including chronic kidney disease (CKD), cardiovascular disease, hypercholesterolemia and neurodegenerative diseases. However, the therapeutic …
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Effect of amino acids and vitamin D3 on performance and biological responses in poultry
… of various concentrations of dietary vitamin D3 on pullet and laying hen performance, eggshell quality and bone health in laying hens. Pullets/hens were randomly assigned to five dietary treatments containing vitamin D3 from 1,681 to 68,348 IU/kg diet from day of hatch until 68 weeks of age. …
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Characterization of Cellular and Genomic Effects of 1,25-Dihydroxyvitamin D3 in Prostate Progenitor/Stem Cells
… studies support the potential for vitamin D3 as a chemopreventative agent for prostate cancer. The prostate cancer stem cell hypothesis, which is still under development, proposes that a transformed adult prostate progenitor/stem cell can give rise to a heterogeneous prostate tumor. Based …
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Synthesis of 20S-Hydroxyvitamin D3 Analogs and Their 1α-Hydroxyl Derivatives as Potent Anti-inflammatory Agents
… treatment options of RA, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] is the only steroidal drug used clinically for anti-inflammatory and immune diseases. However, long-term use of 1,25(OH)2D3 (625 µg/day) in human would result in hypercalcemia (toxicity), and 1,25(OH)2D3 has substantial …
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The Effects of 1,25-Dihydroxyvitamin D3, Docosahexaenoic Acid and 5-Fluorouracil on Human Breast Cancer Cells
It is well documented that vitamin D and DHA have antiproliferative effects on a variety of human cancers, including breast cancer. Studies have shown that a combination approach to cancer treatment is more effective than any one treatment administered alone. In this study, human mammary epithelial …
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The Effects of Dopamine D3 Receptor Compounds on Oxycodone Self-Administration and Reinstatement in Female Cynomolgus Monkeys
… and recent studies indicate the DA D3 receptor (D3R) as a potential therapeutic target for OUD. In addition, sex differences have been identified in opioid pharmacology, yet few preclinical studies have examined opioid self-administration in female subjects. The present thesis …
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1á,25(OH)2-VITAMIN D3 IN PROSTATE: INTERSECTION WITH AKT/PTEN AXIS AND ROLE IN SENESCENCE
The PI3K-AKT pathway is frequently activated in prostate cancer and can lead to downregulation of p21 and p27 levels and function. 1-alpha, 25-dihydroxy vitamin D<sub>3</sub> (1á,25(OH)<sub>2</sub>D<sub>3</sub>) inhibits proliferation of multiple cancer cell types, including prostate cancer cells, …
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