Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"D1R"”.
-
Unravelling the D1R-D2R heteromer
<p>Dopamine receptors D1R and D2R form a heterooligomeric complex with signaling properties distinct from the individual receptors. Aberrant expression of this protein-protein complex is linked to the etiology of various neuropsychiatric diseases. Formation of the D1R-D2R heteromer is thought to be …
-
Functionally selective receptor signaling and endocytosis by dopamine D1 receptor agonists
The dopamine D1 receptor (D1R) is a G protein-coupled receptor that signals through Gs and Golf G proteins. D1R agonists increase cAMP production and recruit β-arrestin to the plasma membrane, which may lead to receptor desensitization and/or induce D1R endocytosis. In addition, the D1R is …
-
Mechanisms of Exercise-Mediated Restoration of Renal Dopamine D1 Receptor Function in Aging
… pressure. Dopamine by activating D1 receptors (D1R) and inhibiting sodium transporters, Na, K-ATPase and Na, H exchanger, in renal proximal tubules (RPTs) promotes sodium excretion and thus maintains sodium homeostasis. The aging process alters vital organ functions including kidney function. …
-
Investigating the Role of Dopamine D1 Receptor Activation in Overcoming Boundary Conditions for Object Identity and Object Location Memory Malleability
… rats, we found that systemic D1 receptor (D1R) antagonist SCH23390 blocked recently encoded and novelty-induced destabilization, and subsequent contextual updating, of relatively remote object identity and object location memories. Systemic D1R agonist SKF38393 was sufficient to induce …
-
Altered Decision Behavior of Dopamine Receptor Knock-out Mice in a Free Binary Choice Task
… of dopamine D1 and D2 receptor-knockout (D1R-KO and D2R-KO, respectively) mice in an instrumental learning task with progressively increasing reversal frequency and in a dynamic foraging task. Performance of D2R-KO mice was progressively impaired in an instrumental learning task as the …
-
Role of Dopamine Receptor 3 in Cardiac Fibrosis
… between excitatory dopamine receptor 1 (D1R) and inhibitory dopamine receptor 3 (D3R) was examined through a dopamine receptor 3 global knock out (D3KO) mouse model. Both receptors were confirmed to express in WT cardiac fibroblast cells and heart tissues through a comprehensive analysis …
-
Exploring central and enteric nervous system vulnerability in Huntington’s Disease: hints from a knock-in animal model
… surface expression of Dopamine receptors 1 (D1R) and 2 (D2R). These two populations exhibit distinct vulnerabilities, with D2R-expressing MSNs impacted earlier in the disease process, though the reasons for this differential susceptibility remain unclear. Understanding the mechanisms …
-
Synthesis and Evaluation of C-10 Nitrogenated Aporphine Alkaloids at Serotonin and Dopamine Receptors
… aporphines with moderate to low affinity at D1R, thus attaining D1R versus D5R selectivity. Compound 128e was the most potent D1R ligand (Ki = 58 nM) and lacked binding affinity at all other dopamine receptor subtypes. Compounds 103a, 108a, and 128e have been identified as three new lead …
-
Neural and neurochemical mechanisms of sustained visual attention
… function. Systemic effects of a Dopamine 1 (D1R) and Dopamine 2 receptor (D2R) agonist were also determined for comparison with the intracerebral administration in Chapter 8. Chapter 8 determined the regional effects of D1R and D2R agonists by microinfusion into the nucleus accumbens (shell …
-
THE ROLE OF DOPAMINE D3 RECEPTOR IN ALCOHOL ADDICTION AND SCHIZOPHRENIA
… of G protein- coupled receptors (GPCR), the D1R-like receptors (D1R and D5R) and D2R- like receptors (D2R, D3R and D4R, Seeman et al., 1994). Among dopamine receptors, the dopamine D3 receptor (D3R) has captured the scientific interest because of its restricted distribution in the brain, …
-
Production of charm mesons by high energy neutrons
… ratio (BR) is defined as: BR =BR(D'"" -+ D1r) x BR(D -+ K+ K-). The dependence of the cross section per nucleus on number of nucleons in the target was fit to a form A a and it was found that a = .96 .17. A sample of 64 ±.16 D; events was investigated for the decay D; -+ 4>1r±. The …
-
A functional study on novel genes involved in regulating aldosterone secretion in normal human zona glomerulosa and in aldosterone-producing adenomas
… from H295R cells by the dopamine receptor D1R agonist fenoldopam and antagonist SCH23390. IHC showed predominantly intracellular staining for D1R in NEFM-rich ZG-like APAs, but membranous staining in NEFM-poor ZF-like APAs. Aldosterone secretion in response to fenoldopam in primary cells …
-
Mutational Analysis to Define the Functional Role of the Third Intracellular Loop of D1-Class Dopaminergic Receptors
… between human D1-class dopaminergic receptors (hD1R and hD5R), have been implicated in modulating their subtype-specific functional phenotypes. The importance of the IL3 for Guanine nucleotide-binding protein (G-protein) coupling and specificity has long been acknowledged in the G-protein-coupled …
-
Anatomical and Physiological Characterization of Striatal Activation of the Cerebral Cortex
… expressing D1 type dopamine (DA) receptors (D1Rs) and indirect pathway MSNs (iMSNs) expressing D2 DA receptors (D2Rs). Loss of DA results in the imbalance between the activities of dMSNs and iMSNs in Parkinson’s disease (PD), leading to ab-normal interactions between the cerebral cortex and …