Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"D1 receptor"”.
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Functionally selective receptor signaling and endocytosis by dopamine D1 receptor agonists
The dopamine D1 receptor (D1R) is a G protein-coupled receptor that signals through Gs and Golf G proteins. D1R agonists increase cAMP production and recruit β-arrestin to the plasma membrane, which may lead to receptor desensitization and/or induce D1R endocytosis. In addition, the D1R is …
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Mechanisms of Exercise-Mediated Restoration of Renal Dopamine D1 Receptor Function in Aging
… and blood pressure. Dopamine by activating D1 receptors (D1R) and inhibiting sodium transporters, Na, K-ATPase and Na, H exchanger, in renal proximal tubules (RPTs) promotes sodium excretion and thus maintains sodium homeostasis. The aging process alters vital organ functions including …
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A Comparison of the Manipulations of Dopaminergic, Opioidergic or Serotonergic Systems within the Nucleus Acccumbens on the Cue-Evoked Relapse to Food-Seeking
… infusions of saline or a selective D1 receptor antagonist, mu-opioid receptor agonist, or the neurotransmitter serotonin prior to cue-evoked reinstatement sessions. Both NAcc D1 receptor antagonism by SCH 23390 and mu-opioid receptor agonism by [D-Ala2, N-MePhe4, Gly-ol]-enkephalin …
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Methamphetamine and amphetamine differentially affect associative learning: behavioral and neurobiological correlates
… mechanisms, namely glucocorticoid or dopamine receptor activation, contribute to these alterations. A second goal was to investigate potential differences in the effects of two psychostimulants; methamphetamine (METH) and amphetamine (AMPH). These drugs were chosen because, while structurally …
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Cell-type specific CB1 receptor modulation of hippocampal synaptic plasticity and memory
… memory and learning mainly via the cannabinoid receptor type 1 (CB1)-dependent regulation of neuronal and glial activity. In the hippocampus, bidirectional communication between neurons and astrocytes shapes synaptic plasticity and behavior. CB1 receptors have been shown to be present in the …
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Modulation of Signal Transduction in the Nervous System by Protein Phosphorylation
… molecular mechanisms by which neurotransmitter receptors transduce their signals: chemically-gated ion channels, receptor-linked ion channels and receptor-linked ion pumps. The nicotinic acetylcholine receptor, a neurotransmitter-gated ion channel, is phosphorylated by a protein tyrosine kinase …
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Νευροφαρμακολογία και λειτουργική ανατομία των βασικών γαγγλίων του εγκεφάλου: Πειραματική μελέτη σε επίμυες
… pointing out a complex interaction between DA receptor subtypes and GABAergic striatal efferents. It is widely accepted that both D1 and D2 dopamine receptors play a role in dopaminergic activity in the basal ganglia. In an attempt to relate the observed differences to the two DA receptor …
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Aspects of tic like behaviour and serotonergic control
… was investigated. The selective dopamine D1 receptor antagonists SCH23390 and SCH39166 and dopamine D2 antagonists raclopride and sulpiride had no effect on MK771 induced blinking. The D1 antagonists attenuated fore-paw-tremor and -licking while the D2 antagonists were generally without …
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The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
… possibly by differentially altering dopamine receptor-responsiveness in the mesolimbic dopamine system. To investigate this hypothesis, our initial studies measured alterations in cAMP-dependent and -independent protein phosphorylation in vivo produced by chronic cocaine and heroin …
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Molecular and Neurochemical Effects of Methylphenidate on the Developing Brain
… monoamine transporter (VMAT2), dopamine D1 receptor, and the catecholamine rate-limiting enzyme tyrosine hydroxylase (TH), in most of the examined brain areas. By using proton nuclear magnetic resonance (1H-NMR) spectroscopy, this thesis also shows that acute MPH enhances the levels of …
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Synthesis and Evaluation of Tetrahydroprotoberberines as Dopamine Receptor Ligands
<p>Dopamine (DA) receptors belong to the G-protein coupled receptors (GPCRs) family, divided in to two groups based on their high homology transmembrane domains; D1-like DA receptors (D1, D5) and D2-like DA receptors (D2-D4). DA receptor specific ligands have been exploited as a means for studying …
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Dopamine D2 Receptor Priming Enhances Dopaminergic Response to Amphetamine in the Nucleus Accumbens: Role of the D1 and D2 Receptors.
… a significant increase in dopamine D<sub>2</sub> receptor sensitivity, a phenomenon known as D<sub>2</sub> receptor priming. Dopamine D<sub>2</sub> receptor priming is common in psychosis. Male and female rats were administered quinpirole (1mg/kg) or saline from postnatal days 1-11 and raised to …
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Altered Decision Behavior of Dopamine Receptor Knock-out Mice in a Free Binary Choice Task
… debate. Specific roles of different dopamine receptor subtypes in this process are also unknown. To investigate roles of dopamine receptor subtypes in reward-based learning, I examined choice behavior of dopamine D1 and D2 receptor-knockout (D1R-KO and D2R-KO, respectively) mice in an …