Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 445 for “"D1"”.
-
Oxidativer Stress in Pflanzen : Untersuchungen zum D1-Phytoprostan-Signalweg
… Arbeit konnte gezeigt werden, dass über den D1-Phytoprostan-Weg zwei weitere Klassen von Phytoprostanen gebildet werden können, die D1-Phytoprostane (PPD1) und die Deoxy-J1-Phytoprostane (dPPJ1). PPD1 und dPPJ1 wurden erstmals durch Partialsynthese hergestellt. Zudem konnten diese …
-
Identifying the Role of Phospholipase D1 and Phosphatidic Acid in Exocytosis
… One protein in particular, phospholipase D1 (PLD1), and its product, the lipid phosphatidic acid (PA), are involved in multiple exocytic processes. However, PLD1 and PA’s role in this process has remained unclear. In this work, PLD1 and the production of PA were visualized during …
-
Functionally selective receptor signaling and endocytosis by dopamine D1 receptor agonists
The dopamine D1 receptor (D1R) is a G protein-coupled receptor that signals through Gs and Golf G proteins. D1R agonists increase cAMP production and recruit β-arrestin to the plasma membrane, which may lead to receptor desensitization and/or induce D1R endocytosis. In addition, the D1R is …
-
REGULATION OF CANCER METASTASIS BY PROTEIN KINASE D1: A GLOBAL REGULATORY CASCADE
<p>Protein Kinase D1 (PKD1) is a serine threonine kinase which is downregulated in Prostate, Breast and Colon Cancer. It functions as a tumor suppressor in different cancer cells. Downregulation of PKD1 is known to be associated with aggressiveness of the cancer. PKD1 is known to regulate many key …
-
Mechanisms of Exercise-Mediated Restoration of Renal Dopamine D1 Receptor Function in Aging
… and blood pressure. Dopamine by activating D1 receptors (D1R) and inhibiting sodium transporters, Na, K-ATPase and Na, H exchanger, in renal proximal tubules (RPTs) promotes sodium excretion and thus maintains sodium homeostasis. The aging process alters vital organ functions including …
-
The role of phospholipase D1 in trafficking and processing of amyloid precursor protein
… model. The role that the other PLD isoform, PLD1, plays in AD is unclear, although cell culture studies from other groups have suggested it modulates the trafficking of APP and presenilin 1, the catalytic subunit of gamma secretase. Here, we investigate the role of PLD1 in the biology of APP as …
-
Effects of arsenic and UVB radiation on induction of cyclin D1 in human keratinocytes.
… that although both cause induction of cyclin D1, culturing cells with both co-mutagens does not lead to a potentiated effect. Evidence from other systems indicates that both arsenic and UVB affect promoter activity in various ways, including methylation. We undertook to examine the effects of …
-
Relationship between astronaut head motion and space motion sickness on Spacelabs 1 and D1
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1989.
-
Sensitivity to Dopamine D1/D2 Receptor Stimulation in Mice Lacking Connexin-32 or Connexin-36
Previous work has shown D1/D2 requisite synergism can still occur in the striatum in the absence of action potentials. Some nonclassical communication such as gap junctions may be allowing the segregated dopamine (DA) receptors to interact to produce stereotyped motor activity. Connexin-32 (Cx32) …
-
THE ROLE OF DMP1 IN HUMAN BREAST CANCER PROGNOSIS AND CYCLIN D1-INDUCED BREAST CANCER
… pathway. Dmp1 physically interacts with cyclin D1 that is frequently overexpressed in breast cancer. Cyclin D1 can either increase or decrease the transcriptional activity of Dmp1 depending the molecular contexts of the targeted genes. Although loss of Dmp1 significantly accelerated oncogenic …
-
The Role of Connexin36 in Dopamine D1/D2 Synergism and its Breakdown in Transgenic Mice
… dopamine require concomitant activation of both D1 and D2 receptors, a phenomenon referred to as D1/D2 synergism. Since D1 and D2 receptors are located mostly on separate neurons, and since D1/D2 synergism occurs in the absence of action potentials, we have suggested that electrotonic coupling …
-
The effects of dopamine D1 and D2 antagonists on cocaine-induced CPP in preweanling rats
The effects of dopamine D1 and D2 antagonists on conditioned place preference (CPP) and locomotor activity were assessed. A total of three experiments were conducted. In each experiment there were two conditioning days followed by a test day. The results indicate that DA D1 and D2 receptors have …
-
The effects of dopamine D1 and D2 antagonists on cocaine-induced CPP in preweanling rats
The effects of dopamine D1 and D2 antagonists on conditioned place preference (CPP) and locomotor activity were assessed. A total of three experiments were conducted. In each experiment there were two conditioning days followed by a test day. The results indicate that DA D1 and D2 receptors have …
-
Deconstructing G Protein-Coupled Receptor Dimer Pharmacology: Case Studies in Dopamine D1 and D2 Receptors
… this assay, we investigated putative dopamine D1-D2 and A2A-D2 receptor dimer functions and studied the issue of a purported G protein coupling switch in the D1-D2 receptor dimer in which the heteromer was proposed to activate Gq, unlike D1 or D2 receptor when expressed alone. We were unable, …
-
Preventing Thymus Involution In K5.Cyclin D1 Transgenic Mice Sustains The Naïve T Cell Compartment With Age
… expressing a keratin 5 promoter-driven Cyclin D1 (K5.D1) transgene in thymic epithelial cells (TECs). Thymopoiesis occurs normally in K5.D1 transgenic thymi and sustains T cell output to prevent the age-associated decline of naïve T cells in the periphery. We find that K5.D1 recent thymic …
-
Protein Kinase D1 in Myeloid Cells Promotes Disease Progression and Severity in S. rectivirgula Induced Hypersensitivity Pneumonitis
… (TLRs) expressed by these cells. Protein kinase D1 (PKD1) has previously been identified as a critical signaling molecule in the TLR signaling pathways of all TLR family members except for TLR3. Our previous research found that activation of protein kinase D1 (PKD1) in the lungs following …
-
Mutational Analysis to Define the Functional Role of the Third Intracellular Loop of D1-Class Dopaminergic Receptors
… are the most divergent regions between human D1-class dopaminergic receptors (hD1R and hD5R), have been implicated in modulating their subtype-specific functional phenotypes. The importance of the IL3 for Guanine nucleotide-binding protein (G-protein) coupling and specificity has long been …
Page 1 of 23