Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"D-serine"”.
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Inhibition of Salmonella gallinarum by D-serine and its reversal
Thesis (M.S.)--Michigan State University of Agriculture and Applied Science. Dept. of Microbiology and Public Health, 1958
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Amino acid racemase responsible for the biosynthesis of D-aspartate and D-serine signaling molecules in Aplysia californica central nervous system
… signaling functions in animal nervous systems. D-serine (D-Ser) can affect the activity and plasticity of N-methyl-D-aspartate (NMDA) receptor, a molecule that forms the basis of learning and memory in the brain. D-aspartate (D-Asp) is found in neuroendocrine and endocrine tissues, potentially …
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Structure-Function and Behavioral Studies on the Glutamate Delta-1 Receptor
… currents through the GluD1 mutant receptors. D-serine and extracellular calcium had opposing effects on GluD1 mutants and a chimeric GluD1-D2 lurcher. D-serine decreased currents through GluD1F655A and chimeric GluD1-D2 lurcher while calcium increased currents through GluD1F655A. These results …
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SMN DEFICIENCY INDUCES NEUROACTIVE AMINOACIDS DYSMETABOLISM: BRIDGING INSIGHTS FROM PRECLINICAL MODELS TO CLINICAL EVIDENCE IN SMA PATIENTS
… acids, including L-glutamate, L-glutamine, D-serine, and D-aspartate, are dysregulated in the CNS and cerebrospinal fluid (CSF) of SMA, compromising glutamatergic neurotransmission—supplementation with D-serine improved motor performance in severe SMA mice, identifying a tractable metabolic …
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Cell-type specific CB1 receptor modulation of hippocampal synaptic plasticity and memory
… By allowing physiological availability of D-serine at NMDA receptors via gliotransmission, astrocytes are important elements controlling glia-neuron interactions that underlie synaptic plasticity and memory functions. The data show that astroglial CB1 receptors control plasticity and memory …
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Synthesis of Biologically Relevant Sphingolipid Analogues
… been synthesised in 16 steps starting from D-serine. The synthetic route was developed such that future introduction of different aryl groups is straightforward. Throughout the synthetic coarse, we gained access to a number of structural analogues, which provided more insight into the …
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An Account of Chemical and Mechanical Regulation of TRPC6 Channels in Podocytes
… large ionic currents that are potentiated by D-serine. Given their resistance to L-glutamate-induced activation, podocyte NMDA receptors likely do not act in a localized glomerular signaling system. However, their response to ligands that circulate in both the normal and pathological state …
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Analysis of endogenous D-amino acids in the central nervous system and endocrine system via capillary electrophoresis with biochemical sample treatment
… and memory. A well-studied D-amino acid is D-serine that works as a signaling molecule in the nervous system and its abnormal concentration can cause some pathological states. However, the other endogenous amino acids still require further study to establish their metabolic pathways, …
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Measuring D-amino acids in the central nervous system using capillary electrophoresis
… two D-AAs are studied extensively, namely D-serine (D-Ser) and D-aspartate (D-Asp). D-Ser can be synthesized endogenously by serine racemase which converts L-Ser to D-Ser. D-Ser can affect the activity of N-methyl-D-aspartate (NMDA) receptor, which is an important receptor involved in …
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Sources and Biochemical Composition of Detrital Organic Matter In theSea
… the presence of D-aspartic acid (D-Asx) and D-serine (D-Ser) suggested that heterotrophic sources were substantial. The average reactivity of bacterial organic matter was comparable to that of the bulk organic carbon pool. Bacteria were important sources of labile, semilabile and refractory …
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Purinergic Signalling and Potassium Homeostasis Regulate Somatosensory Adaptation
… include: ATP, glutamate (Glu), and D-serine (Bowser & Khakh, 2004; Jourdain et al., 2007; Quon et al., 2018). ATP has been shown to not only be released from astrocytes but also activate them causing the further release of gliotransmitters, specifically Glu (Gallagher & Salter, 2003). …
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Contribution of different types of phospholipids in blood coagulation
… take place on membranes with exposed phosphatidylserine (PS). GLA domains are the most common PS-binding motifs in blood coagulation. A further intriguing aspect of the membrane’s contributions to clotting is that phosphatidylethanolamine (PE) supports little or no clotting activity in the absence …