Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"D-box"”.
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Development of peptide inhibitors as molecular therapeutics against tandem-repeat proteins
… motifs (degrons) on its substrates: the D-box, the KEN box and the ABBA motif. The regulation of mitotic exit is tightly controlled by modulating the levels of Cdc20 and Cdh1 through different stages of the cell cycle. Cdc20 overexpression is associated with many cancers. Currently, no …
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Diacylglycerol lipaseα-dependent endocannabinoid signaling in neural stem cells
… consensus motif for a putative destruction (d-) box that might target DAGL for ubiquitin-proteasome mediated degradation. No evidence was found to support that the d-box is involved in DAGLα degradation, however first indications towards degradation through the ubiquitin-proteasome pathway were …
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INSIGHTS INTO SUBSTRATE RECOGNITION BY THE ANAPHASE PROMOTING COMPLEX (APC)
… via binding to degrons, such as the destruction box (D-box), KEN-box, and ABBA motif. However, not all substrates contain these degrons. Moreover, D- and KEN-box sequences are found in many proteins that are clearly not APC substrates, indicating that additional factors must contribute to …
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Understanding Structural And Functional Mechanisms of Emi1 Inhibition of the Anaphase Promoting Complex
… Emi1 has an APC/C recognition motif called a D-box that is typically found within APC/C substrates. Emi1’s D-box is recruited to the substrate-binding sites of APC/C and serves as a pseudo-substrate inhibitor. Emi1 also inhibits through distinct mechanisms both of the E2 enzymes that coordinate …
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Investigating how ubiquitin-mediated proteolysis of AURKA contributes to its activity in the cell cycle
… and activity. I show that the previously known D-box-like motif (R371xxL374) within C-terminal is not a functional degron. I also reveal that the A-box motif may act as an atypical D-box that is sufficient to drive protein degradation. I use a new tool CRISPR/Cas9 FZR1 knockout cell line and a …
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Study of space-time evolution of flux in a long-life traveling wave reactor
… condition. For the analyses of flux shape, a 3-D box-shaped model of the reactor is developed. The reactor core is divided into two primary regions: the smaller, enriched region with fissile material; and the larger non-enriched region with fertile material. This enrichment strategy is aimed to …
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Präparation und röntgenkristallographische Untersuchungen an archaebakteriellen Box C/D sRNPs und einer neuartigen Glukosyltransferase aus Thermotoga maritima MSB8
… von Uridin in Pseudouridin durch die H/ACA-Box snoRNAs und zum anderen zur 2'-O-Methylierung von Ribose durch Box C/D snoRNAs, wobei beide snoRNA-Familien mit spezifischen Proteinen zu kleinen nukleolären Ribonukleoprotein Partikeln (snoRNPs) assembliert sind. In zellkernlosen Prokaryonten …
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The developmental role and regulation of the Anaphase-Promoting Complex/Cyclosome in Drosophila meiosis
… CORT is rapidly degraded in an APC/C and D-box-dependent manner. We initiated a genetic screen to identify substrates of APC/CCORT using grauzone (grau) mutants, a gene encoding a transcriptional activator of cort. We have identified at least one deficiency on the third chromosome, …
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Mechanism of APC/C activation and substrate specificity in mitosis
… interacts with a coactivator-binding site (C-box binding site), thereby obstructing engagement of Cdc20. Phosphorylation of the auto-inhibitory segment displaces it from the C-box binding site to relieve APC/C auto-inhibition. Efficient phosphorylation of the auto-inhibitory segment requires …
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Viral and Host Genetic Determinants of Hepatitis C Virus Persistence and Interferon Resistance
… caspase recruitment domain (CARD) of the DExH/D-box helicase protein RIG-I, a component of the TLR3-independent intracellular dsRNA-responsive IRF-3 activation pathway, was responsible for this phenotype. Restoration of RIG-I-mediated IRF-3 activation through genetic complementation resulted in …
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Uncertainty in atmospheric CO₂ concentrations from a parametric uncertainty analysis of a global ocean carbon cycle model
… enhancements over the more simple 0-D and 1-D box-diffusion models upon which it is based, including latitudinal extension of mixed-layer inorganic carbon chemistry, climate-dependent air-sea exchange rates, and mixing of dissolved inorganic carbon into the deep ocean that is parameterized by …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… of BMI values, revealing that SNORD46—a C/D box small nucleolar RNA—is elevated in obese donors and inversely associates with NK cell tumor infiltration across cancer types. Saturated fatty acids drive C/EBPβ phosphorylation at T235, promoting SNORD46 transcription and secretion from …